PROTAC-mediated FTO protein degradation effectively alleviates diet-induced obesity and hepatic steatosis.

Demethylation of N-Methyladenosine (m6A) by fat mass and obesity-associated protein (FTO) occurs in the development of obesity and fatty liver disease. In this study, we synthesized FTO-degradation targeted chimera (FTO-DT), which exhibited excellent lipid-lowering activity at low concentration. At a concentration of 0.

Polystyrene nanoplastics exposure triggers spermatogenic cell senescence via the Sirt1/ROS axis.

Polystyrene nanoplastics (PS-NPs) have been reported to accumulate in the testes and constitute a new threat to reproductive health. However, the exact effects of PS-NPs exposure on testicular cells and the underlying mechanisms remain largely unknown. The C57BL/6 male mice were orally administered with PS-NPs (80 nm) at different dosages (0, 10, and 40 mg/kg/day) for 60 days, and GC-1 cells were treated with PS-NPs in this study.

Ultrasonic-assisted synthesis of MOF-199 on the surface of carboxylated cellulose fibers for efficient adsorption of methylene blue.

A high-efficiency porous adsorbent, MOF-199/carboxylated cellulose fibers (MOF-199/CCF), was synthesized at room temperature through carboxylation modification, simple sonication, and vacuum drying. The sonication method produced small MOF-199 particles (tens of nanometers), which allowed for uniform distribution of MOF-199 on CCF and improved its efficiency. The presence of CCF carriers reduces the agglomeration of MOF-199 and enhances its performance.

Desorption Characteristics of CH-CH Mixed Gas in Heavy Hydrocarbon-Rich Coal Seams.

The gas desorption characteristics of coal are closely related to the gas content of the coal seam. The gas in heavy hydrocarbon-rich coal seams contains CH and CH heavy hydrocarbons. However, most current research on the gas desorption characteristics of coal seams focuses on CH analysis, ignoring the influence of the CH heavy hydrocarbon gas.

Anisotropic Damage Mechanism of Coal Seam Water Injection with Multiphase Coupling.

After coal seam water injection, coal mechanical properties will change with brittleness weakening and plasticity enhancement. Aiming at the problem of coal damage caused by the coal seam water injection process, based on nonlinear pore elasticity theory and continuum damage theory, a nonlinear pore elastic damage model considering anisotropic characteristics is proposed to calculate and analyze the gas-liquid-solid multiphase coupling effect with the fully coupled finite element method during the coal seam water injection process. The research results indicate that the wetting radius of calculated results by the model agrees well with the in situ test results, and the relative errors are less than 10%.

Maternal history of Alzheimer's disease predisposes to altered serum cholesterol levels in adult offspring.

Controversial findings regarding the association between serum cholesterol levels and Alzheimer's disease (AD) have been identified through observational studies. The genetic basis shared by both factors and the causality between them remain largely unknown. The objective of this study is to examine the causal impact of maternal history of AD on changes in serum cholesterol levels in adult offspring.

Anti-adhesion multifunctional poly(lactic-co-glycolic acid)/polydimethylsiloxane wound dressing for bacterial infection monitoring and photodynamic antimicrobial therapy.

Wound infection and adhesion are important factors affecting wound healing. Early detection of pathogen infection and reduction of wound-to-dressing adhesion are critical for improving wound healing. Herein, Ester-J, which can rapidly respond to lipase secreted by bacteria, was designed and synthesized.

Experimental Study on Coal and Gas Outburst Risk under Different Water Content Rates in Strong Outburst Coal Seams.

To investigate the alleviation potency of coal seam water infusion on coal and gas outburst, this paper focuses on the Qidong coal mine outburst coal seam, where outburst accidents have occurred many times, and obtains the impact of water content on outburst prediction parameters by studying the features of outburst parameters and gas desorption law under different water content rates. How water content affects outburst was also researched through the use of a self-made outburst simulation test system, and the relationship between water content and outburst intensity and critical gas pressure was studied. It can be concluded that with the rise of water content, the initial velocity of gas diffusion, the gas desorption index of drilling cuttings, and the adsorption constant decrease, but the firmness coefficient () increase, and these indicators are exponentially related to the water content.

Relationship between dietary carotenoid intake and sleep duration in American adults: a population-based study.

Objective: To investigate the relationship between dietary carotenoid intake and sleep duration.

Methods: Adults enrolled in the National Health and Nutrition Examination Survey (NHANES) 2007-2018 without missing information on dietary carotenoid intake (α-carotene, β-carotene, β-cryptoxanthin, lycopene, and lutein + zeaxanthin), sleep duration, and covariates were included. Participants' carotenoid consumption was divided into three groups by quartiles and sleep duration was grouped as short (< 7 h/night), optimal (7-8 h/night), and long (> 8 h/night).

Genetic association between coffee/caffeine consumption and the risk of obstructive sleep apnea in the European population: a two-sample Mendelian randomization study.

Background: The association between coffee/caffeine consumption and obstructive sleep apnea (OSA) risk remains unclear.

Purpose: To determine the relationship between coffee/caffeine consumption and the risk of OSA, using the Mendelian randomization (MR) method in the European population.

Methods: Two sets of coffee consumption-associated genetic variants were, respectively, extracted from the recent genome-wide meta-analysis (GWMA) and genome-wide association study (GWAS) of coffee consumption.

Dietary choline intake and non-alcoholic fatty liver disease (NAFLD) in U.S. adults: National Health and Nutrition Examination Survey (NHANES) 2017-2018.

Background: Whether there is an association between dietary choline intake and non-alcoholic fatty liver disease (NAFLD) in American adults remains unclear.

Methods: Data came from the National Health and Nutrition Examination Survey 2017-2018. Choline intake was defined by the mean amounts of two 24 h dietary recalls, and choline intake was categorized into three groups according to the quartiles: inadequate (P).

Microplastics cause reproductive toxicity in male mice through inducing apoptosis of spermatogenic cells via p53 signaling.

Background: Studies on male reproductive toxicity of microplastics are still scarce and the precise mechanism is not distinct.

Methods: C57BL/6 male mice were given oral gavage treatments treated with 5 μm (MPs) and 80 nm (NPs) polystyrene microplastics every day for 60 consecutive days in a row at dosages of 0, 10 and 40 mg/kg/d. The major damage of MPs and NPs were assessed by the assays in vivo and in vitro.

Improvement of physicochemical stability and digestive properties of quercetagetin using zein-chondroitin sulfate particles prepared by antisolvent co-precipitation.

Zein-quercetagetin-chondroitin sulfate (Zein-Que-CS) composite nanoparticles with different compositions were successfully fabricated using a novel antisolvent co-precipitation method. The mean particle diameter (97.5 to 219.

Lymph node ratio precisely predicts the benefit of postoperative radiotherapy in esophageal cancer: A retrospective cohort study.

Background: The matter of postoperative radiotherapy (PORT) in esophageal cancer (ESCA) was far from conclusive. Some evidence indicated that lymph node status could affect treatment. We evaluated lymph node ratio (LNR) as an indicator that could be applied to predict PORT benefit.

Associations of serum zinc, copper, and selenium with sleep disorders in the American adults: Data from NHANES 2011-2016.

Background: Even though various studies have been conducted to investigate the relationship between trace metals and sleep, few epidemiological studies have evaluated the relationship between trace metals and sleep disorders in American adults.

Objective: This study intended to evaluate the associations of serum zinc (Zn), copper (Cu), selenium (Se), Zn/Cu, Zn/Se, and Cu/Se ratios with sleep disorders in American adults.

Methods: We conducted a cross-sectional analysis of 3660 adults aged ≥18 years old who participated in the National Health and Nutrition Examination Survey (NHANES) 2011-2016.

Physical activity, sedentary behavior, and the risk of type 2 diabetes: A two-sample Mendelian Randomization analysis in the European population.

Physical activity (PA) and sedentary behaviors (SB) have been linked to the risk of type 2 diabetes (T2DM) in observational studies; however, it is unclear whether these associations are causative or confounded. This study intends to use summary genetic data from the UK Biobank and other consortiums in conjunction with the two-sample Mendelian Randomization (MR) approach to solve this problem. The inverse variance weighted (IVW) technique was utilized as the primary analysis, with sensitivity analyses using the MR-Egger, weighted-median, and MR-Pleiotropy RESidual Sum and Outlier (PRESSO) techniques.

The causal impact of childhood obesity on bone mineral density and fracture in adulthood: A two-sample Mendelian randomization study.

Observational studies have indicated the associations between obesity with bone mineral density (BMD) and fracture but yield inconsistent results. The impact of childhood obesity on bone health in adulthood is even less clear. The present study adopted the Mendelian randomization methods to determine whether the genetically predicted childhood obesity was causally associated with BMD and the risk of fracture.

Genetic association between circulating selenium level and the risk of schizophrenia in the European population: A two-sample Mendelian randomization study.

Background: The association between circulating the selenium level and the risk of schizophrenia remains unclear.

Objective: To determine the relationship between the circulating selenium level and the risk of schizophrenia, using the Mendelian Randomization method in the European population.

Methods: Single nucleotide polymorphisms (SNPs) associated with the circulating selenium level were identified at < 5 × 10.

Relay detection of Cu and bovine serum albumin by a dansyl derivative-based fluorescent probe.

A dansyl derivative-based fluorescent probe, namely, DGly, was developed for relay detection of Cu and bovine serum albumin (BSA) with high selectivity and sensitivity. The fluorescence intensity of DGly at 540 nm displayed "on-off-on" phenomenonafter Cu and BSA were added in sequence. Correspondingly, the solution color changed from yellow to dark and then to yellowish white under 365 nm UV light irradiation; thus, the solution could be detected by the naked eye.

Clusterin protects against Cr(VI)-induced oxidative stress-associated hepatotoxicity by mediating the Akt-Keap1-Nrf2 signaling pathway.

Hexavalent chromium [Cr(VI)] is a serious environmental pollutant that threatens human life. Cr(VI) is widely used in industrial processes such as metallurgy, leather processing, and electroplating, which can enter the human body through the respiratory or digestive tracts, thus causing a number of human disease, including inflammation and cancer. Although it has been confirmed that oxidative stress is one of the primary mechanism of liver injury caused by Cr(VI) exposure, the related toxic target and effective intervention measures have not been found.

Multifunctional wound dressing for rapid hemostasis, bacterial infection monitoring and photodynamic antibacterial therapy.

Wound management is a major global issue, and there is a growing challenge to develop more effective hemostatic dressings to control bleeding and prevent pathogen infections. In this study, a multifunctional wound dressing was developed to meet the clinical need. The hemostatic layer of wound dressing can quickly stop the bleeding.

Polystyrene microplastics trigger hepatocyte apoptosis and abnormal glycolytic flux via ROS-driven calcium overload.

Human health could be affected by the spread of microplastics in the food chain. Our previous research has indicated that microplastics accumulated in the liver and subsequently induce oxidative damage. However, the molecular events linking oxidative stress to calcium ion (Ca) signaling during microplastics stress remains elusive.

Clusterin inhibits Cr(VI)-induced apoptosis via enhancing mitochondrial biogenesis through AKT-associated STAT3 activation in L02 hepatocytes.

Improper treatment of a large amount of industrial waste makes hexavalent chromium [Cr(VI)] seriously pollute the atmosphere, soil and water, and enter the food chain, seriously affecting the health of workers and local residents. We previously proved that Clusterin (CLU) can inhibit the apoptosis of L02 hepatocytes induced by Cr(VI) through mitochondrial pathway, but the associated molecular mechanism has not been further studied. Mitochondrial biogenesis is an important step in mitochondrial damage repair, but the mechanism of mitochondrial biogenesis in Cr(VI)-induced liver toxicity is still unclear.

Role of Clusterin/NF-κB in the secretion of senescence-associated secretory phenotype in Cr(VI)-induced premature senescent L-02 hepatocytes.

Hexavalent chromium [Cr(VI)] and its compounds have caused serious environmental pollution and health damage. Senescent cells can actively change the surrounding environment by secreting some factors, which are called senescence associated secretory phenotype (SASP). Our previous work has confirmed that premature senescent hepatocytes induced by Cr(VI) expressed high level of Clusterin (CLU) and secrete interleukin-6 (IL-6) and IL-8.