T- and pH-Dependent Hydroxyl-Radical Reaction Kinetics of Lactic Acid, Glyceric Acid, and Methylmalonic Acid in the Aqueous Phase.

Carboxylic acids are a common class of compounds found in atmospheric aerosols and cloud droplets. In this study, the oxidation kinetics of several carboxylic acids in the aqueous phase by the atmospherically relevant OH radical were investigated to better understand the loss processes for this class of compounds. The rate constants for the reactions of the OH radical were determined using the thiocyanate competition kinetics method for lactic acid, glyceric acid, and methylmalonic acid as a function of temperature and pH.

Hawthorn leaves flavonoids attenuate cardiac remodeling induced by simulated microgravity.

Context: Hawthorn leaves are a kind of widely used medicinal plant in China. The major ingredient, hawthorn leaves flavonoids (HLF), have cardiotonic, cardioprotective, and vascular protective effects.

Objective: The study evaluated the protective role of HLF in cardiac remodelling and the underlying mechanisms under simulated microgravity by hindlimb unloading rats.

miR-153-3p, a new bio-target, is involved in the pathogenesis of acute graft-versus-host disease via inhibition of indoleamine- 2,3-dioxygenase.

Acute graft-versus-host disease (aGVHD) is a major cause of morbidity and mortality after allogeneic hematopoietic stem cell transplantation. Therefore, seeking reliable biomarkers and delineating the potential biological mechanism are important for optimizing treatment strategies and improving their curative effect. In this study, using a microRNA polymerase chain reaction (PCR)-based chip assay, microRNA-153-3p (miR-153-3p) was screened and selected as a potential biomarker of aGVHD.