Publications by authors named "Yuehua Wang"

Article Synopsis
  • The NLRP3 inflammasome is crucial in inflammatory diseases, and its activation is influenced by mitochondrial damage and oxidative stress.
  • The study shows that Nepetin (Nep), a natural flavonoid, enhances the process of mitophagy and inhibits NLRP3 inflammasome activation in macrophages, showcasing its antioxidant effects.
  • In mice with systemic inflammation or obesity, Nep improved survival, reduced organ damage, and lowered inflammation, supporting its potential as a therapeutic anti-inflammatory agent.
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The present study was undertaken to investigate the therapeutic effect and underlying mechanisms of lumbrokinase (LK) on diabetic kidney disease (DKD). Kidney tissue samples from DKD patients and normal controls were collected from hospitals. The type 2 diabetic nephropathy model was induced in db/db mice.

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L. (VU), rich in polyphenols, is an important wild berry resource primarily distributed in extremely cold regions. However, the detailed composition of L.

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Article Synopsis
  • * The study investigated how lymphangiogenesis relates to RIF in DKD, using mouse models and cellular studies, finding that high-glucose conditions lead to increased lymphangiogenesis and inflammatory responses, worsening RIF.
  • * Empagliflozin was shown to reduce RIF in DKD by inhibiting the VEGF-C/VEGFR-3 pathway, thus decreasing lymphangiogenesis, and this research adds to the
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Glioblastoma represents the predominant and a highly aggressive primary neoplasm of the central nervous system that has an abnormal metabolism. Our previous study showed that chrysomycin A (Chr-A) curbed glioblastoma progression in vitro and in vivo. However, whether Chr-A could inhibit orthotopic glioblastoma and how it reshapes metabolism are still unclear.

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Purpose: Preventing and treating diabetic nephropathy (DN) are global challenges due to the complexity and diversity of its causes and manifestations. It is important to find effective medications to treat DN.

Patients And Methods: Gene expression files of DN were downloaded from the GEO database to identify the differentially expressed genes.

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Multiple plant hormones, including strigolactone (SL), play key roles in regulating flowering time. The Arabidopsis (Arabidopsis thaliana) DWARF14 (AtD14) receptor perceives SL and recruits F-box protein MORE AXILLARY GROWTH2 (MAX2) and the SUPPRESSOR OF MAX2-LIKE (SMXL) family proteins. These interactions lead to the degradation of the SMXL repressor proteins, thereby regulating shoot branching, leaf shape, and other developmental processes.

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Utilization of thin Li metal is the ultimate pathway to achieving practical high-energy-density Li metal batteries (LMBs), but its practical implementation has been significantly impeded by formidable challenges of poor thinning processability, severe interphase instability and notorious dendritic Li growth. Here we report a practical thin (10-40 μm) Li/Mo/LiSe with concurrently modulated interphase and mechanical properties, achieved via a scalable mechanical rolling process. The in situ generated LiSe and Mo not only enhance the mechanical strength enabling the scalable fabrication of thin Li metal, but also promote homogeneous Li electrodeposition.

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C1R has been identified to have a distinct function in cutaneous squamous cell carcinoma that goes beyond its role in the complement system. However, it is currently unknown whether C1R is involved in the progression of hepatocellular carcinoma (HCC). HCC tissues were used to examine C1R expression in relation to clinical and pathological factors.

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Drought stress inhibits plant growth and agricultural production. Improving plant instantaneous water use efficiency (iWUE), which is strictly regulated by stomata, is an effective way to cope with drought stress. However, the mechanisms of iWUE regulation are poorly understood.

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Article Synopsis
  • Patients with clinically significant portal hypertension (CSPH) should be treated with non-selective beta-blockers like carvedilol to prevent liver decompensation, especially using liver stiffness (LS) measurements as a less invasive alternative to hepatic venous pressure gradient (HVPG) measurements.
  • A study is planned to determine if patients with compensated cirrhosis and LS≥25 kPa can benefit from carvedilol, focusing on a randomized, double-blind, placebo-controlled trial involving 446 adults.
  • The primary outcome will be the incidence of decompensation events and liver-related deaths over three years, while secondary outcomes will include various complications of portal hypertension such as
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Plants rely on strigolactones (SLs) to regulate their development and form symbiotic relationships with microbes as part of the adaptive phosphorus (P) efficiency strategies. However, the impact of SLs on root-associated microbial communities in response to P availability remains unknown. Here, root microbiota of SL biosynthesis () and perception () were compared to wild-type Col-0 plants under different P concentrations.

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Anthocyanin (AN) has good antioxidant and anti-inflammatory bioactivities, but its poor biocompatibility and low stability limit the application of AN in the food industry. In this study, core-shell structured carriers were constructed by noncovalent interaction using tannic acid (TA) and poloxamer 188 (F68) to improve the biocompatibility, stability and smart response of AN. Under different treatment conditions, TA-F68 and AN were mainly bound by hydrophobic interaction.

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Background: Cetaceans, having experienced prolonged adaptation to aquatic environments, have undergone evolutionary changes in their respiratory systems. This process of evolution has resulted in the emergence of distinctive phenotypic traits, notably the abundance of elastic fibers and thickened alveolar walls in their lungs, which may facilitate alveolar collapse during diving. This structure helps selective exchange of oxygen and carbon dioxide, while minimizing nitrogen exchange, thereby reducing the risk of DCS.

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The digestive instability of anthocyanins (ACNs) limits their application in food nutrition, especially precision nutrition. Blueberry ACNs-loaded nanoparticles (Lipo/GA-ACNs NPs) were prepared using gum arabic (GA) as the delivery carrier and liposomal vesicles (Lipo) prepared from soy lecithin as the targeting scaffold. The average particle size of the NPs was 99.

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Objectives: In diabetes, chronic hyperglycemia increases the overactivation of oxidative phosphorylation of mitochondria in the liver, resulting in oxidative stress (OS) damage. The Nrf2 signaling pathway plays a key role in preventing hepatic oxidative injury and inflammation. This study aims to investigate the therapeutic effect and mechanism of Modified Buyang Huanwu Decoction (mBYHWD) on diabetic liver injury (DLI) by regulating oxidative stress mediated by Nrf2 signaling pathway.

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Objective: Unilateral mastectomy is known to induce postural alterations, yet the temporal development pattern of these changes remains elusive. This study aimed to explore the impact of unilateral mastectomy on body posture.

Methods: A prospective, longitudinal, observational study with a one-group repeated-measures design was conducted.

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Diabetic kidney disease (DKD) is a major microvascular complication of diabetes, and hyperglycemic memory associated with diabetes carries the risk of disease occurrence, even after the termination of blood glucose injury. The existence of hyperglycemic memory supports the concept of an epigenetic mechanism involving n6-methyladenosine (m6A) modification. Several studies have shown that m6A plays a key role in the pathogenesis of DKD.

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Anthocyanins (ACNs) systems encapsulated in nanomaterials have received widespread attention and rapid development due to its good delivery potential. Here, the favorable benefits of four natural polysaccharide food additives coated ACNs-liposome nanoparticles (ACNs-Lipo NPs) on the stability and possible lipid-lowering effects of ACNs are discussed in this work. The polysaccharides were coupled to the ACNs-Lipo NPs and self-assembled to create ACNs-Lipo@polysaccharide NPs.

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Background: Chemotherapy-induced thrombocytopenia (CIT) is a common hematological complication in patients with cancer. Hetrombopag is a novel thrombopoietin receptor agonist that has shown an additive effect in stimulating platelet production when combined with recombinant human thrombopoietin (rhTPO).

Objectives: This multicenter retrospective cohort study aimed to evaluate the efficacy and safety of hetrombopag plus rhTPO compared with rhTPO alone for CIT.

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Objective: Seizures are one of the complications that can occur after cranioplasty (CP). In some regions, titanium mesh remains the material of choice for CP. However, risk factors for seizures after titanium CP have been less studied.

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Article Synopsis
  • Dopaminergic neurons in the substantia nigra are particularly prone to damage from rotenone, which contributes to the neuron loss seen in Parkinson's disease, and baicalein has potential neuroprotective effects.
  • In experiments with SH-SY5Y cells, baicalein was shown to enhance K-ATP channel activity and counteract the harmful effects of rotenone by dealing with reactive oxygen species and mitochondrial dysfunction.
  • The study indicates that baicalein binds strongly to the SUR1 protein, which is involved in K-ATP channels, suggesting it could be a valuable target for preventing neuron degeneration in Parkinson's disease.
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The full combination of high sensitivity indication and long-lasting bacteriostatic function is an innovative need to meet the practicality of intelligent film packaging systems for food products. Hence, Blueberry anthocyanins (BA) copigmentated by ferulic acid (FA) was used as an indicator, and cinnamon essential oil (CO) encapsulated by β-cyclodextrin (β-CD) as a bacteriostat, potato starch (PS) as a film-forming substrate to prepared a dual-function starch-based intelligent active packaging film with pH indicator and antibacterial function. FA had the best copigmentation effect with a threefold increase in a value compared to other phenolic acids.

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The mechanisms through which stocking rates affect soil organic carbon in desert steppe landscapes are not fully understood. To address this research gap, we investigated changes in the biomass of Stipa breviflora plant communities and soils in a desert steppe. Through our research findings, we can establish an appropriate stocking rate for Stipa breviflora desert steppe.

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Synopsis of recent research by authors named "Yuehua Wang"

  • - Yuehua Wang's recent research focuses on various aspects of health and disease, particularly in diabetic conditions, cancer treatment, and plant biology, demonstrating a multifaceted approach to scientific inquiry.
  • - Significant findings include the potential of empagliflozin in protecting against renal interstitial fibrosis in diabetic kidney disease through lymphangiogenesis inhibition, and the role of chrysomycin A in reshaping glioblastoma metabolism to hinder progression.
  • - Additionally, Wang's work extends to environmental interactions, showcasing how plant hormones can influence root microbiota in response to phosphorus availability and exploring cellular mechanisms underlying disease processes, such as HIF-1α-regulated glycolysis in hepatocellular carcinoma.

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