Establishment of a staging model for Parkinson's disease in mice.

The Parkinson's disease is the second most common neurodegenerative disease with different pathological mechanisms at each stage. To investigate Parkinson's disease further, this study was proposed to develop a continuous staging mouse model of Parkinson's disease to reproduce the pathological features of different stages of Parkinson's disease. We successively treated the mice with MPTP, and assessed the behavioral performance of the mice with the open field test and the rotarod test, and detected the aggregation of α-syn and the expression of TH protein in the substantia nigra of the mice with western blot test and immunofluorescence test.