Publications by authors named "Yuehua Li"

Ferroptosis is a type of non-apoptotic regulated cell death characterized by iron accumulation and lipid peroxidation. Cisplatin is an effective chemotherapy drug with several serious side effects including acute kidney injury (AKI). Asprosin is a peptide contributing to metabolism regulation and metabolic disorders.

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Background: The infiltration of macrophages into the lungs is a common characteristic of perivascular inflammation, contributing to vascular remodeling in pulmonary hypertension (PH). Peli1 (pellino E3 ubiquitin-protein ligase 1) plays a critical role in regulating the production of proinflammatory cytokines and the polarization of macrophages in various diseases. However, the role of Peli1 in PH remains to be investigated.

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Study Design: Retrospective.

Objective: To explore the value of time-resolved CE-MRA in evaluating and locating the SVM prior to digital subtraction angiography (DSA).

Summary Of Background Data: Spinal vascular malformations (SVM) can be detected with time-resolved contrast-enhanced MRA(CE-MRA).

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Developing a generalist radiology diagnosis system can greatly enhance clinical diagnostics. In this paper, we introduce RadDiag, a foundational model supporting 2D and 3D inputs across various modalities and anatomies, using a transformer-based fusion module for comprehensive disease diagnosis. Due to patient privacy concerns and the lack of large-scale radiology diagnosis datasets, we utilize high-quality, clinician-reviewed radiological images available online with diagnosis labels.

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Introduction: It remains unclear whether the local amyloid-beta (Aβ) burden in key regions within the default mode network (DMN) affects network and cognitive functions.

Methods: Participants included 1002 individuals from the Chinese Preclinical Alzheimer's Disease Study cohort who underwent 18F-florbetapir positron emission tomography resting-state functional magnetic resonance imaging scanning and neuropsychological tests. The correlations between precuneus (PRC) Aβ burden, DMN function, and cognitive function were investigated.

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Introduction: Mechanical thrombectomy (MTB) is a critical procedure for acute ischemic stroke (AIS) patients. However, the free-text format of MTB surgical records limits the formulation of effective postoperative patient management and rehabilitation plans. This study compares the efficacy of large language models (LLMs) in structuring data from these free-text MTB surgical record.

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Background: Regulatory T cells (Tregs) play a critical role in shaping the immunosuppressive microenvironment within tumors. Investigating the role of Tregs in Clear cell renal cell carcinoma (ccRCC) is crucial for identifying prognostic markers and therapeutic targets for ccRCC.

Methods: Weighted gene co-expression network analysis (WGCNA) was utilized to pinpoint modules related to Treg infiltration in TCGA-KIRC samples.

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Breast cancer (BC) is a common malignancy that affects women worldwide. Although transducing beta-like 2 (TBL2), a member of the WD40 repeat protein family, has been implicated in various intracellular signaling pathways, its precise function in BC remains unclear. The expression of TBL2 is analyzed using real-time PCR, western blotting, and immunohistochemistry in BC patient specimens.

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A comprehensive analysis of the immune response triggered by intraoperative radiation therapy (IORT) remains incomplete. In this study, single-cell RNA sequencing and single-cell T cell receptor sequencing are conducted on peripheral blood mononuclear cells (PBMCs) from patient with early-stage breast cancer before and after IORT. Following IORT combined with surgery (defined as IORT+Surgery), PBMC counts remained stable, with increased proportions of T cells, mononuclear phagocytes, and plasma cells, and a reduction in neutrophil proportions.

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Article Synopsis
  • - Sepsis often causes high lactate levels and acute lung injury (ALI), with clinical studies linking elevated lactate to higher mortality in septic patients.
  • - Researchers found that during sepsis, lactate triggers changes in cold-inducible RNA-binding protein (CIRP) within macrophages, leading to the release of CIRP, which then interacts with pulmonary vascular endothelial cells (PVECs) to promote cell death pathways.
  • - The study reveals that lactate-induced CIRP release stabilizes Z-DNA binding protein 1 (ZBP1) in PVECs, exacerbating ALI through a cell death mechanism known as PANoptosis, emphasizing a potentially new target for treating sepsis-related complications. *
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  • The study investigates the role of excessive sympathetic activity in causing vascular remodeling in hypertension by performing local sympathetic denervation through superior cervical ganglionectomy (SCGx) on two types of rats: Wistar-Kyoto (WKY) rats and spontaneously hypertensive rats (SHR).
  • Results showed that SCGx did not significantly affect blood pressure or heart rate but reduced vascular remodeling in specific arteries associated with the sympathetic nervous system, while it had minimal impact on non-sympathetic arteries.
  • The findings suggest that sympathetic overactivity is a key factor in vascular changes associated with hypertension, as evidenced by improvements in blood flow and reduced oxidative stress and inflammation in denervated arteries of SHR
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Atherosclerosis-induced lethal cardiovascular disease remains a severe healthcare threat due to the limited drug efficiency and untimely prediction of high-risk events caused by inadequate target specificity of medications, incapable recognition of insensitive patients, and variable morphology of vulnerable plaques. Therefore, it is necessary to develop efficient strategies to improve the diagnosis accuracy and achieve visualized treatment of atherosclerosis. Herein, we establish an inflamed endothelium-targeted three-in-one nucleic acid nanogel system that can reverse the inflammatory state of endothelial cells (ECs) in plaques and simultaneously achieve real-time monitoring of the therapy process for efficient atherosclerosis diagnosis and treatment.

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Sepsis-induced acute lung injury (ALI), characterized by severe hypoxemia and pulmonary leakage, remains a leading cause of mortality in intensive care units. The exacerbation of ALI during sepsis is largely attributed to uncontrolled inflammatory responses and endothelial dysfunction. Emerging evidence suggests an important role of Z-DNA binding protein 1 (ZBP1) as a sensor in innate immune to drive inflammatory signaling and cell death during infections.

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Magnesium (Mg) alloys are a promising candidate for synthetic bone tissue substitutes. In bone tissue engineering, achieving a balance between pore characteristics that facilitate biological functions and the essential stiffness required for load-bearing functions is extremely challenging. This study employs binder jet additive manufacturing to fabricate an interconnected porous structure in Mg alloys that mimics the microporosity and mechanical properties of human cortical bone types.

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Article Synopsis
  • Scientists created a computer program called ReportGuidedNet that helps find brain problems in MRI scans by using information from radiology reports.
  • They tested this program on thousands of brain scans from different hospitals and compared it to another program called PlainNet that didn’t use report info.
  • ReportGuidedNet did a much better job at diagnosing brain conditions and understanding where to look on the scans, making it more reliable and easier to explain its findings.
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  • MOSPD1 is found to be overexpressed in breast cancer (BC) tissues compared to normal tissues, indicating a possible role in cancer progression and poor patient outcomes.
  • Functional experiments demonstrated that reducing MOSPD1 levels inhibited tumor growth and improved the effectiveness of anti-PD-L1 therapy in BC cells.
  • The study suggests that MOSPD1 could serve as a biomarker for negative clinical outcomes and a potential therapeutic target to enhance treatment responses in patients with breast cancer.
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Lung adenocarcinoma (LUAD), characterized by a low 5-year survival rate, is the most common and aggressive type of lung cancer. Recent studies have shown that tertiary lymphoid structures (TLS), which resemble lymphoid structures, are closely linked to the immune response and tumor prognosis. The functions of the tertiary lymphoid structure-related genes (TLS-RGs) in the tumor microenvironment (TME) are poorly understood.

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Background And Purpose: Peak width of skeletonized mean diffusivity (PSMD) is an MRI-based biomarker that may reflect white matter lesions (WML). PSMD is based on skeletonization of MR DTI data and histogram analysis. Both chronic renal failure (CRF) and WML may be affected by multisystemic small-vessel disorder.

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Proliferation of renal tubular epithelial cells (TEC) is essential for restoring tubular integrity and thereby to support renal functional recovery from kidney ischemia/reperfusion (KI/R) injury. Activation of transcriptional factor c-Myc promotes TEC proliferation following KI/R; however, the mechanism regarding c-Myc activation in TEC is incompletely known. Heat shock protein A12A (HSPA12A) is an atypic member of HSP70 family.

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In recent years, the emergence of multidrug-resistant bacteria has limited the selection of drugs for treating bacterial infections, reduced clinical efficacy, and increased treatment costs and mortality. It is urgent to find alternative antibiotics. In order to explore a new method for controlling methicillin-resistant Staphylococcus aureus (S.

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  • Deep learning (DL) has the potential to enhance the diagnosis of cerebral aneurysms by utilizing large multicenter data sets for better segmentation and detection in CT angiography (CTA) images.
  • A retrospective collection of CTA images from eight hospitals was used to develop and test a DL model, with performance assessed against radiology reports using the Dice similarity coefficient and receiver operating characteristic curves.
  • The model demonstrated a high accuracy with a DSC of 0.87 for segmentation and 85.7% sensitivity in detecting aneurysms, performing comparably to traditional radiology assessments and processing scans relatively quickly in 1.76 minutes.
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Time-of-flight magnetic resonance angiography (TOF-MRA) is a non-contrast technique used to visualize neurovascular. However, manual reconstruction of the volume render (VR) by radiologists is time-consuming and labor-intensive. Deep learning-based (DL-based) vessel segmentation technology may provide intelligent automation workflow.

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