Publications by authors named "Yueh-Ying Chen"
Article Synopsis
- Urinary tract infections (UTIs) are complicated by antibiotic-resistant uropathogens, and this study evaluated the effectiveness of 18 heat-killed probiotics and their supernatants in reducing biofilm formation and dispersing existing biofilms against these pathogens.
- Fourteen probiotic strains significantly inhibited UPEC biofilm formation by 20-80% and reduced existing biofilms by 10-60%, while eight strains also effectively targeted Methicillin-resistant E. coli (MREC).
- The study concluded that certain heat-killed probiotics could promote biofilm dispersion and lower urinary bacterial load in an animal model, indicating their potential as a treatment for UTIs.
Article Synopsis
- The study focuses on a strain of streptococcus that has a gene cluster for type IV pili (Tfp), which are implicated in cell adherence but not in twitching motility.
- The transcription of the gene cluster was found to be regulated by a distal promoter, with optimal expression occurring during the early stationary growth phase, despite the absence of a typical regulatory sequence.
- Deletion of certain pilin genes led to reduced cell adherence and biofilm formation, indicating that the Tfp in this strain is crucial for adherence to host cells but does not contribute to motility.
Article Synopsis
- This study examines the role of CodY, a regulator in Streptococcus salivarius, in response to changes in pH and glucose availability within the oral environment.
- Findings show that CodY is most active at neutral pH with limited glucose, affecting the bacterium’s transcriptome through both direct and indirect mechanisms.
- The research indicates that CodY is crucial for the bacteria's metabolism, virulence, and ability to evade the immune system, while also influencing biofilm formation and cell wall metabolism.
Article Synopsis
- GlnR regulates the GlnR regulon for acid tolerance in S. mutans, especially at acidic pH levels.
- New findings reveal that PmrA also influences this regulon at the transcriptional level, particularly at neutral pH (pH 7).
- Mutations in either GlnR or PmrA decrease S. mutans' survival in acidic conditions, while their regulation impacts biofilm formation, helping the bacteria thrive in the oral cavity.
Article Synopsis
- A study was conducted to create one-dimensional fibers made of PbI₂ and polyvinylpyrrolidone (PVP) using an electrospinning process with N,N-dimethylformamide as the solvent.
- Dipping these fibers into a CH₃NH₃I solution resulted in a color change, indicating the successful formation of CH₃NH₃PbI₃, leading to the production of CH₃NH₃PbI₃/PVP composite fibers.
- The researchers analyzed the structure, shape, and composition of the fibers using X-ray diffraction and scanning electron microscopy techniques.
Article Synopsis
- The study investigated the relationship between human papillomavirus (HPV) infection and the expression of ATAD3A, an anti-autophagy factor, in uterine cervical cancer (UCC), finding that high-risk HPV was present in 88.9% of cases.
- ATAD3A expression was observed in 79.2% of UCC cases and was significantly associated with several factors, including HPV presence, cancer stage, lymph node involvement, and patient survival.
- Silencing HPV genes reduced ATAD3A levels and cell survival, while decreasing ATAD3A or using resveratrol increased autophagy and apoptosis, suggesting that persistent HPV infection may enhance ATAD3A expression