Publications by authors named "Yueh-Shan Li"
Article Synopsis
- - The study shows that stiff stromal environments in pancreatic tumors trigger damage and repair in nuclear envelopes of precursor cells, leading to genetic mutations that aid tumor growth.
- - Researchers used mouse models to investigate pancreatic cancer cell origins, finding that the extracellular matrix can influence acinar cells to transform into specialized cancer cells with specific genetic amplifications linked to poor prognosis.
- - Disabling certain signaling pathways in cancer cells improved survival rates in mice by promoting cell death and altering tissue structure, highlighting potential treatment strategies targeting these vulnerabilities.
Purpose: Neurodegenerative diseases are associated with neuroinflammation along with activation of microglia and oxidative stress, but currently lack effective treatments. Punicalagin is a natural bio-sourced product that exhibits anti-inflammatory effects on several chronic diseases; however, the anti-inflammatory and anti-oxidative effects on microglia have not been well examined. This study aimed to investigate the effects of punicalagin on LPS-induced inflammatory responses, NLRP3 inflammasome activation, and the production of ROS using murine microglia BV2 cells.
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