Synthesis and Biological Evaluation of Reniochalistatins A-E and a Reniochalistatin E Analogue.

The total synthesis of reniochalistatins A-E, along with a reniochalistatin E analogue (inverso-E) was successfully achieved through Fmoc-based solid-phase peptide synthesis and subsequent macrolactamization with PyBOP and DIEA. The biological activities of these reniochalistatins and a key linear peptide intermediate were systematically evaluated. Among these seven synthesized compounds, linear reniochalistatin B was found to have potent activity against several cancer cell lines not shown by the cyclic reniochalistatin B counterpart.

[Study on structural properties of biochar under different materials and carbonized by FTIR].

Infrared spectroscopy (IR) is an important means of seeing the characteristics of the structural properties. Fourier transform infrared spectroscopy (FTIR) was applied to analyze the structural properties of biochar from different materials with different methods. The results showed that: the biochars have IR absorption peaks of hydroxyls group, aromatic group and containing organic group with the activated? charcoal, but in other absorption peaks, with a significant difference.