Repetitive transcranial magnetic stimulation impacts the executive function of patients with vascular cognitive impairment: a systematic review and meta-analysis.

Objective: Executive dysfunction is a core symptom of vascular cognitive impairment (VCI), which seriously affects patients' prognosis. This paper aims to investigate the effectiveness of rTMS on executive function in VCI.

Methods: The databases selected for this study included Pubmed, Embase, Cochrane Library, China National Knowledge Infrastructure (CNKI), Wanfang, China Science and Technology Journal Database (VIP), and China Biology Medicine Disc (CBM).

The varying clinical effectiveness of single, three and five intraarticular injections of platelet-rich plasma in knee osteoarthritis.

Objective: To investigate the variations in clinical effectiveness among patients diagnosed with knee osteoarthritis who underwent intra-articular administration of platelet-rich plasma using single, triple, or quintuple injections.

Methods: One hundred twenty patients with grade I-III knee osteoarthritis were randomly assigned to three groups: PRP1 group, who received a single injection of platelet-rich plasma; PRP3 group, who received three PRP injections one week apart; PRP5 group, who received five PRP injections one week apart. The patients' conditions were evaluated using the Visual Analogue Scale (VAS) and the Western Ontario and McMaster Universities Arthritis Index-VA3.

Characterization of Potting Epoxy Resins Performance Parameters Based on a Viscoelastic Constitutive Model.

To describe the evolution of residual stresses in epoxy resin during the curing process, a more detailed characterization of its viscoelastic properties is necessary. In this study, we have devised a simplified apparatus for assessing the viscoelastic properties of epoxy resin. This apparatus employs a confining cylinder to restrict the circumferential and radial deformations of the material.

Impact of autologous platelet-rich plasma therapy vs. hyaluronic acid on synovial fluid biomarkers in knee osteoarthritis: a randomized controlled clinical trial.

Objective: Observe the effects of platelet-rich plasma (PRP) therapy on inflammatory cytokines in the synovial fluid of the knee joint of patients with KOA, and explore the effects of PRP intra-articular injection on the inflammation of the knee joint environment and the possible mechanism of action.

Methods: Seventy patients were randomized to undergo three blinded weekly intra-articular injections of PRP or hyaluronic acid (HA). The concentrations of inflammatory cytokines, including interleukin (IL)-6, IL-1β, tumor necrosis factor (TNF)-α, IL-8, IL-17A, IL-17F, IL-4, IL-5, and IL-10, in the synovial fluid were evaluated before the intervention and 1 month after the third injection.

Dust source tracing and their transport mechanisms before monsoon season from three glaciers at the Tibetan Plateau: revelations from REE analysis and an indirect tracing approach.

Understanding the origins of Tibetan Plateau (TP) glacier dust is vital for glacier dynamics and regional climate understanding. In May 2016, snow pit samples were collected from glaciers on the TP: Qiyi (QY) in the north, Yuzhufeng (YZF) in the center, and Xiaodongkemadi (XDK) in the south. Rare earth element (REE) concentrations were analyzed using inductively coupled plasma mass spectrometry (ICP-MS), and near-surface PM concentrations were extracted from a dataset of Chinese near-surface PM.

Pollution revealed by stable lead isotopes in recent snow from the northern and central Tibetan Plateau.

Lead (Pb) isotopes are less fractionated than those from different sources, and thus were used to trace the sources of Pb in the environment. To investigate the sources of Pb in the atmosphere of the Tibetan Plateau, stable Pb isotopes (Pb, Pb and Pb) in acidified snow pit samples collected from five glaciers (i.e.

Application of vagus nerve stimulation on the rehabilitation of upper limb dysfunction after stroke: a systematic review and meta-analysis.

Objective: This study aimed to elucidate the efficacy, safety, and long-term implications of vagus nerve stimulation (VNS) as a viable therapeutic option for patients with upper limb dysfunction following a stroke.

Methods: Data from the following libraries were searched from inception to December 2022: PubMed, Wanfang, Scopus, China Science and Technology Journal Database, Embase, Web of Science, China Biology Medicine Disc, Cochrane Library, and China National Knowledge Infrastructure. Outcomes included indicators of upper limb motor function, indicators of prognosis, and indicators of safety (incidence of adverse events [AEs] and serious AEs [SAEs]).

Association between short-term exposure to ambient air pollution and number of outpatient Helicobacter pylori infection visits.

Helicobacter pylori infection (HPI) is an important risk factor of gastrointestinal diseases, but factors leading to it are still not fully understood. To investigate the association between short-term exposure to air pollution and HPI during outpatient visits, we collected daily data for HPI outpatient visits and air pollutant concentrations during 2014-2021 in Hefei, Anhui Province, China. A time-stratified case-crossover design was performed to analyze the acute impacts of air pollution on HPI outpatient visits.

Whole body hypoxic preconditioning-mediated multiorgan protection in db/db mice nitric oxide-BDNF-GSK-3β-Nrf2 signaling pathway.

The beneficial effects of hypoxic preconditioning are abolished in the diabetes. The present study was designed to investigate the protective effects and mechanisms of repeated episodes of whole body hypoxic preconditioning (WBHP) in db/db mice. The protective effects of preconditioning were explored on diabetesinduced vascular dysfunction, cognitive impairment and ischemia-reperfusion (IR)-induced increase in myocardial injury.

Provenance tracing of dust using rare earth elements in recent snow deposited during the pre-monsoon season from mountain glaciers in the central to northern Tibetan Plateau.

To provide insight into dust sources in snow deposited during the non-monsoon period on the Tibetan Plateau, detailed post-Archean Australian shale (PAAS)-normalized rare earth element (REE) distribution patterns and variations in REE tracers, such as La/Yb, La/Er, and Gd/Yb with depth, as well as the distribution of samples in the plots of REE ratio pairs, such as La/Yb vs. Y/ΣREE, La/Er vs. Gd/Er, and Y/La vs.

Iron in the NEEM ice core relative to Asian loess records over the last glacial-interglacial cycle.

Mineral dust can indirectly affect the climate by supplying bioavailable iron (Fe) to the ocean. Here, we present the records of dissolved Fe (DFe) and total Fe (TDFe) in North Greenland Eemian Ice Drilling (NEEM) ice core over the past 110 kyr BP. The Fe records are significantly negatively correlated with the carbon-dioxide (CO) concentrations during cold periods.

Atmospheric pollution revealed by trace elements in recent snow from the central to the northern Tibetan Plateau.

In order to determine the current levels, spatial distribution patterns, and potential pollution of trace elements (TEs) in the atmosphere of the Tibetan Plateau (TP), snow pit samples were collected in May 2016 from five TP glaciers: Qiyi (QY), Hariqin (HRQ), Meikuang (MK), Yuzhufeng (YZF), and Xiaodongkemadi (XDKMD). Concentrations of 13 TEs (Al, Ba, Cd, Co, Cr, Cu, Fe, Li, Pb, Sb, Sr, U, and Zn) in the snow were measured. The spatial distribution patterns and depth profiles of TEs from the studies sites revealed that the influence of dust on TEs was more significant on the MK and YZF glaciers than on the QY, HRQ, and XDKMD glaciers.

Salmonella Typhimurium and Salmonella Enteritidis Infections in Sporadic Diarrhea in Children: Source Tracing and Resistance to Third-Generation Cephalosporins and Ciprofloxacin.

Objectives: This study aimed to trace the transmission source of Salmonella enterica serovar Typhimurium and Salmonella enterica serovar Enteritidis strains associated with enteric infections in Shanghainese children, and understand the molecular mechanism of resistance to third-generation cephalosporins and ciprofloxacin.

Materials And Methods: The profiles of pulsed-field gel electrophoresis (PFGE) were compared among the isolates from children, animal, and environment. Antimicrobial susceptibility was determined using the minimal inhibitory concentrations and Kirby-Bauer disk diffusion method.

Identification and Characterization of Fluoroquinolone Non-susceptible Clones Harboring Tetracycline and Macrolide Resistance in Shanghai, China.

, also known as group A (GAS), is one of the top 10 infectious causes of death worldwide. Macrolide and tetracycline resistant GAS has emerged as a major health concern in China coinciding with an ongoing scarlet fever epidemic. Furthermore, increasing rates of fluoroquinolone (FQ) non-susceptibility within GAS from geographical regions outside of China has also been reported.

Epidemiological surveillance of hand, foot and mouth disease in Shanghai in 2014-2016, prior to the introduction of the enterovirus 71 vaccine.

Hand, foot, and mouth disease (HFMD) is mainly epidemic in China and Southeast Asian countries. A novel enterovirus 71 vaccine has been available in China for preventing severe HFMD since 2016. Knowledge of the dynamic epidemiology of HFMD in different regions is necessary for appropriate intervention strategies.

Signals of pollution revealed by trace elements in recent snow from mountain glaciers at the Qinghai-Tibetan plateau.

In order to extract pollution signal of trace elements (TEs) in glacier snow at the Qinghai-Tibetan plateau of China by human activities, concentrations of 18 TEs (Al, Ti, Fe, Rb, Sr, Ba, V, Cr, Mn, Li, Cu, Co, Mo, Cs, Sb, Pb, Tl, and U), 14 rare earth elements (La, Ce, Pr, Nd, Sm, Eu, Gd, Tb, Dy, Ho, Er, Tm, Yb, and Lu), Y and Th in digested snow samples from five glaciers in April-May 2013 before monsoon season were measured. Results shown that higher TEs concentrations were found in glaciers at the northern plateau while lower concentrations in glaciers at the central and southern plateau. Discussion revealed that EF values calculated from elements with mass fraction <30% such as Ti and Al, etc in traditional acid leached samples, will overestimate at least 4.

Spatial variations and sources of trace elements in recent snow from glaciers at the Tibetan Plateau.

Trace elements (TEs) could pose a potential threat to the environment and human health and hence they have been paid attention increasingly at present. This study presents the acid-leached concentrations of TEs (e.g.

Measles Outbreak in Pediatric Hematology and Oncology Patients in Shanghai, 2015.

Background: Despite substantial progress toward measles control are making in China, measles outbreaks in immunocompromised population still pose a challenge to interrupt endemic transmission. This study aimed to investigate the features of measles in pediatric hematology and oncology patients and explore the reasons behind the outbreak.

Methods: We collected demographic, epidemiological, and clinical data of immunocompromised measles children.

A novel miR-200b-3p/p38IP pair regulates monocyte/macrophage differentiation.

Monocyte/macrophage differentiation represents a major branch of hematopoiesis and is a central event in the immune response, but the molecular mechanisms underlying are not fully delineated. Here we show that p38 mitogen-activated protein kinase (MAPK) interacting protein (p38IP) is downregulated during monocyte/macrophage differentiation in vitro. Overexpression of p38IP halted monocyte/macrophage differentiation, whereas forward knockdown of p38IP by RNA interference induced G1/S arrest and promoted monocyte differentiation into macrophages and the maturation of macrophages as well.

[Epidemiological surveillance of hand, foot and mouth disease in Shanghai, 2010-2014].

Objective: To understand the epidemiological profiles of hand, foot and mouth disease (HFMD) and the major enteroviruses causing the epidemics of HFMD in Shanghai from 2010 to 2014.

Method: The city-wide surveillance data between 2010 and 2014 were used to analyze the epidemiologic characteristics of the HFMD outbreaks in Shanghai. The annual incidence of HFMD was estimated based on the 2010 Shanghai Census data.

Nontyphoidal salmonella infection in children with acute gastroenteritis: prevalence, serotypes, and antimicrobial resistance in Shanghai, China.

Information about nontyphoidal Salmonella (NTS) infection in children is limited in mainland China. The objective of this study was to investigate the prevalence, serotypes, and antibiotic resistance patterns of NTS infection in children in Shanghai. All cases with probable bacterial diarrhea were enrolled from the enteric clinic of a tertiary pediatric hospital between July 2010 and December 2011.

The p38-interacting protein (p38IP) regulates G2/M progression by promoting α-tubulin acetylation via inhibiting ubiquitination-induced degradation of the acetyltransferase GCN5.

p38-interacting protein (p38IP) is a component of the GCN5 histone acetyltransferase-containing coactivator complex (GCN5-SAGA complex). It remains unclear whether p38IP or GCN5-SAGA is involved in cell cycle regulation. Using RNA interference to knock down p38IP, we observed that cells were arrested at the G2/M phase, exhibiting accumulation of cyclins, shrunken spindles, and hypoacetylation of α-tubulin.

A microreactor and imaging platform for studying chemical oscillators.

We present a laser scanning confocal microscopy (LSCM) and continuous flow microreactor (CFMR)-based platform to study the Belousov-Zhabotinsky (BZ) oscillators. We demonstrated that the scanning laser light below a certain power had no detectable influence on the BZ reaction. The CFMR consisted of the poly(methyl methacrylate) (PMMA) microwell and the polydimethylsiloxane (PDMS) microchannel and maintained the oscillation with a continuous supply of the catalyst-free BZ mixture.

Outbreak of scarlet fever associated with emm12 type group A Streptococcus in 2011 in Shanghai, China.

Background: An unprecedented, large outbreak of childhood scarlet fever occurred in Shanghai between April and July 2011. Investigation of the epidemiology could enhance our understanding of the factors related to the outbreak.

Methods: We retrospectively analyzed the demographic and seasonal characteristics of children with scarlet fever and the outcome.