Identification biomarkers in disease progression of obstructive sleep apnea from children serum based on WGCNA and Mfuzz.

Obstructive sleep apnea (OSA) syndrome is a prevalent form of respiratory sleep disorder, with an increasing prevalence among children. The consequences of OSA include obesity, diabetes, cardiovascular disease, and neuropsychological diseases. Despite its pervasive impact, a significant proportion of individuals especially children remain unaware that they suffer from OSA.

Intraoperative cryoanalgesia on reducing post-tonsillectomy pain scales: a meta-analysis of randomized controlled trials.

Objective: To assess the effect of intraoperative cryoanalgesia on subjective pain scores of patients after tonsillectomy.

Methods: A systematic review of PubMED, Web of Science, EMBASE was performed using the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) standards. For the first time, we included and quantitative synthesized English-language randomized controlled trials (RCT) evaluating patients of all age groups with benign pathology who underwent tonsillectomy with intraoperative cryoanalgesia versus without.

Association between sleep duration and hearing threshold shifts of adults in the United States: National Health and Nutrition Examination Survey, 2015-2016.

Background: Obstructive sleep apnea (OSA) is linked to hearing loss (HL). Another sleep characteristics, sleep duration might also be associated with HL, but prior evidence is limited. This study is aimed to investigate the association between sleep duration and hearing level in the adult US population.

Urinary pyrethroid metabolite and hearing threshold shifts of adults in the United States: A cross-sectional study.

Hearing loss (HL) is a global health problem with a high prevalence and profound socioeconomic impact. Pyrethroids are one of the most commonly used insecticides. Although previous studies have reported the relationship between pyrethroids and neurotoxicity, little is known about the effect of pyrethroid exposure on the auditory system among the general population.

[Effect of the NF-κB/iNOS Signaling Pathway on Spiral Ganglion in Mouse Model of Sensorineural Hearing Loss].

Objective: To explore the effect of changes in the expression level of necorsis factor (NF)-κB/inducible nitric oxide synthase (iNOS) signaling pathway on hearing loss in a mouse model of sensorineural hearing loss (SNHL) induced by 3-nitropropionic acid (3-NP).

Methods: The animal model was established by tympanic injection. C57BL/6 male mice were divided into three groups, 3-NP group receiving tympanic injection of 3-NP solution, 3-NP+EVP4593 group receiving tympanic injection of 3-NP solution and intraperitoneal injection of EVP4593 solution, and a control group receiving tympanic injection of phosphate buffered saline (PBS).

Assessing the Quality of Hearing Aids-Related Videos on TikTok.

Hearing aids are effective at improving listening ability and health-related quality of life. Recently, we observed that there are many hearing aids-related videos published on TikTok. However, the quality of the information they offer remains unstudied.

[Effect of Connexin on Cochlear Blood-Labyrinth Barrier in a Mouse Model of Endolymphatic Hydrops].

Objective: To examine the expression of tight-junction connexin ZO-1 in the stria vascularis tissue of the cochlea by using spontaneous endolymphatic hydrops animal model constructed with gene mutant mice, and to analyze the dynamic changes of the gene mutant mice in pathology, imaging, and hearing function.

Methods: Male Hyp-Duk/Y mice with gene mutation were selected as the experimental group at three time points, 21 days post birth (P21), 90 days post birth (P90) and 120 days post birth (P120), and wild-type male mice of the same ages were selected as the control groups. The cochlear sections were HE-stained in order to observe whether endolymphatic hydrops was present or absent and to assess its severity.

Effects of Functional Rhinoplasty on Nasal Obstruction: A Meta-Analysis.

Background: Functional rhinoplasty (FRP) is used to improve nasal ventilation by correcting problems with the nasal valves. It has not been systematically reviewed on a large scale.

Methods: A comprehensive literature search was conducted in the PubMed, EMBASE, and Cochrane Library databases to identify studies evaluating nasal obstruction before and after functional rhinoplasty in patients with nasal valve problems.

Urine caffeine metabolites and hearing threshold shifts in US adults: a cross-sectional study.

Previous studies have reported the relationship between effect of caffeine and many diseases. However, studies to evaluate the association between caffeine and hearing loss are contradictory. To examine the relationship of urinary caffeine metabolites with the hearing threshold in US adults, a total of 849 adults aged 20-69 years who participated in the National Health and Nutrition Examination Survey (NHANES, 2011-2012) were enrolled in this study.

Olfactory changes after endoscopic sinus surgery for chronic rhinosinusitis: A meta-analysis.

Background: Endoscopic sinus surgery (ESS) is an important treatment modality for chronic rhinosinusitis (CRS). However, its effect on olfaction remains controversial.

Objective Of Review: To assess the olfactory impact of ESS in patients with CRS.

[The distribution of perivascular-resident cells in blood-labyrinth barrier observed with two-photon fluorescence microscope and Imaris deconvolution].

To determine the cell types composing blood-labyrinth barrier in stira vascularis of cochlear lateral wall, analyze the distribution of these composing cells in blood-labyrinth barrier, and to investigate the relationship between perivascular-resident macrophages （PVMs）, endothelial cells and pericytes in blood-labyrinth barrier. Cochlear lateral wall tissues were harvested from adult GFP-transgenic mice（C57BL/6）. Then the isolated whole stria vascularis tissue was scanned at 0.

Lipopolysaccharide disrupts the cochlear blood-labyrinth barrier by activating perivascular resident macrophages and up-regulating MMP-9.

Objective: To determine the distribution of perivascularresident macrophages (PVMs) in BLB and their relationship with capillaries, and to explore the possible mechanisms responsible for lipopolysaccharide (LPS)-induced activation of PVMs and the breakdown of BLB.

Methods: Adult Balb/c mice were either trans-tympanically injected with LPS, or mock-treated. Auditory brainstem response was tested before and 48 h after treatments.

Distribution of Tryptophan Hydroxylase Immunoreactivity in the Spiral Ganglion Neurons of Mouse Cochlea.

Serotonin, also known as 5-hydroxytryptamine, is an important neurotransmitter and neuromodulator in the nervous system. Spiral ganglion neurons (SGNs) are the first station of the peripheral afferent auditory nervous system. We have previously demonstrated positive serotonin immunoreactivity in mouse SGNs.

Expression and localization of histamine H, H, and H receptors in rat olfactory epithelium.

Objective: Histamine is an important chemical mediator in the development of allergic rhinitis and plays a key role in eliciting the nasal symptoms of the disorder. Histamine may also affect smell as a neurotransmitter. However, whether histamine receptors are present in the mammalian olfactory epithelium has not yet been examined.

Atrial natriuretic peptide reduces the α-subunit of the epithelial sodium channel mRNA expression in the mouse stria vascularis.

Atrial natriuretic peptide (ANP) is extensively expressed in the cochlea, including the strial vascularis (StV). ANP may participate in the regulation of the water-electrolyte balance. However, the functional significance of ANP in the cochlea is less understood and little is known regarding the exact mechanisms.

Case presentation of an intranasal ectopic tooth in a pediatric patient.

An ectopic tooth in the nasal cavity is a rare phenomenon, especially on the inferior turbinate. In most of the reported cases, no etiological explanation of the intranasal teeth has been suggested or found. In children, intranasal ectopic teeth are usually associated with cleft lip and alveolus.

5-HT1A receptor-mediated activation of outward potassium current by serotonin in mouse cultured spiral ganglion neurons.

Cochlear spiral ganglion neurons provide the only pathway for transmitting sound evoked activity from the hair cells to the central auditory system. Serotonin plays a role in the response properties of central auditory neurons. However, knowledge about the role of serotonin in the peripheral auditory nervous system remains limited.

Expression of proteasome activator REGγ in human laryngeal carcinoma and associations with tumor suppressor proteins.

The functional significance of the proteasome activator REGγ in the regulation of cell proliferation and apoptosis has been recognized. However, pathological contributions to tumor development remain to be elucidated. Both oncogenic proteins and tumor suppressors are targeted by REGγ for proteasomal degradation.

[Resection of anterior skull base cranio-nasal communication tumors via the inner plate of frontal sinus-epidural approach].

Objective: To explore the application of inner plate of frontal sinus-epidural approach in the treatment of anterior skull base cranio-nasal communication tumors.

Method: A study of 6 cranio-nasal communication tumor patients was undertaken. They were treated with lateral rhinotomy-inner plate of frontal sinus-epidural approach to remove tumor.

[Electrophysiologic study of murine spiral ganglion neurons].

Objective: To explore the nature of voltage dependent ion channels and basic electrophysiological characteristics of cochlear spiral ganglion neurons of apical and basal turn by patch clamp techniques of whole cell configure on murine spiral ganglion neurons.

Method: Different voltage dependent ionic currents were recorded with patch clamp techniques of whole cell configure on the condition of different internal electrode solution, blockers and stimulus protocol.

Result: Inward sodium channel current (I(Na)), hyperpolarization-activated inward cationic current (Ih), outward delay rectification potassium current (I(K)) and outward transient potassium current (I(A)) were recorded ,significant difference of electrophysiological characteristics of I(A) and I(K) was found between apical and basal turns (P < 0.

The expression of atrial natriuretic peptide receptor in the mouse inner ear labyrinth.

Objective: To compare the relative expression levels of NPR-A mRNA in the stria vascularis (StV), nonstrial tissue of the cochlear lateral wall (NSt) and vestibula in the mouse inner ear to determine the potential contribution of ANP signaling in different parts to inner ear fluid homeostasis.

Setting: Atrial natriuretic peptide (ANP) is a cardiac hormone known to be involved in the regulation of body fluid homeostasis. It is assumed that ANP might also participate in the regulation of inner ear fluid dynamics.

Detection of atrial natriuretic peptide receptor in the labyrinth of the mouse inner ear.

Objectives: To examine whether the atrial natriuretic peptide receptor (NPR-A) is present in the secretory regions of the membrane labyrinth of the adult mouse inner ear.

Setting: Recent studies have implied that the homeostasis of endolymph fluid in the inner ear may be regulated by receptor-mediated mechanisms. Several studies have identified the presence of atrial natriuretic peptide receptors in the inner ear of guinea pig and rat.