A signal amplifying MOF-based probe:on-site and ultrasensitive dual-channel portable detection of Hg in groundwater through a fluorimetrically and RGB-based sensing assay.

Mercury (II) ions (Hg) are a significant source of heavy metal contamination in groundwater, posing a serious threat to human health and the environment. Therefore, there is an urgent need for the development of a new detection technique with high sensitivity for monitoring Hg in contaminated groundwater. Here, we developed a signal amplifying MOF-based probe (NXS@ZIF-8) for on-site and ultrasensitive dual-channel portable detection of Hg in groundwater.

Nonpolar P-type Conjugated Small Molecules Enable High-Performance Organic Photodetectors for Potential Application in Optical Wireless Communication.

The high responsivity and broad spectral sensitivity of organic photodetectors (OPDs) present a bright future of commercialization. However, the relatively high dark current density still limits its development. Herein, two novel nonpolar p-type conjugated small molecules, NSN and NSSN, are synthesized as interface layers to enhance the performance of the OPDs, which not only can tune energy alignments and increase the reverse charge injection barrier but also can reduce the interfacial trap density.

Tunable Multisoliton State Ultrafast Fiber Laser Based on NiSe and Generation of Vector Dual-Wavelength Solitons.

As a member of the chalcogenide family, NiSe exhibits a direct bandgap of 1.74 eV, making it a promising candidate for nonlinear optical devices. However, its potential in the near-infrared region of the telecommunication band has not been fully explored.

Armored polymyxin B: a nanosystem for combating multidrug-resistant Gram-negative bacilli.

Bacterial infections cause high morbidity and mortality worldwide, and the emergence of drug-resistant bacteria further complicates the treatment of infections. Therefore, it is necessary to continuously develop new treatment methods. Polymyxin B (PMB), as the last line of defense, can combat most aerobic Gram-negative bacilli including common drug-resistant bacteria in clinical practice.

Regulating the Atomic Active Center by Covalent Organic Framework-Derived Photothermal Nanozyme to Arm Self-Gelling Powder for Bacterial Wound Healing.

Creating simple methods to produce antioxidant nanozymes with clear structure-activity relationships, particularly aiming to improve disinfection and create practical drug formulations for bacterial wound healing, remains a crucial challenge. Herein, we synthesized iron-loaded covalent organic framework nanospheres, which were then controllably transformed into a carbon-based nanozyme with both iron single atoms and iron clusters through simple pyrolysis. We discovered that the gradual growth of iron clusters significantly boosted the nanozyme's adsorption onto the substrate and electron transfer, greatly influencing its activity.

UV/Ozone-Induced Interface Engineering for High-Performance Horizontal Organic Light-Emitting Transistors Operating at Low Voltage.

Multifunctional organic light-emitting transistors (OLETs), which combine electric-switching and light-producing capabilities into a single device, are attracting increasing interest as promising candidates for new-generation display technology. Despite advancements in the design of organic luminescent materials and the optimization of device geometry configurations, maintaining operating voltage low while enhancing optical performances remains a key challenge in horizontally structured OLETs. Here, a simple and effective interfacial engineering strategy is employed to improve the optical properties of horizontal OLETs operating at low voltage, by introducing ultraviolet ozone (UVO)-induced surface modification on high-k dielectrics.

GABA receptor π forms channels that stimulate ERK through a G-protein-dependent pathway.

The rare γ-aminobutyric acid type-A receptor (GABAR) subunit π (GABRP) is highly expressed in certain cancers, where it stimulates growth through extracellular-regulated kinase (ERK) signaling by an uncharacterized pathway. To elucidate GABRP's signaling mechanism, we determined cryoelectron microscopy (cryo-EM) structures of GABRP embedded in native nanodiscs, both in the presence and absence of GABA. Structurally, GABRP homopentamers closely resemble heteropentameric GABAR anion channels, transitioning from a closed "resting" state to an open "active" state upon GABA binding.

Inhibition of XIST restrains paclitaxel resistance in breast cancer cells by targeting hsa-let-7d-5p/ATG16L1 through regulation of autophagy.

Breast cancer is a fatal malignant tumor in women worldwide. The development of paclitaxel resistance remains a challenge. Autophagy is considered to have a significant part in the chemotherapeutic stress mechanism.

Construction and evaluation of glycoprotein-based nucleic acid vaccines for Marburg virus.

Marburg virus (MARV) is a zoonotic virus that can infect humans and non-human primates (NHPs) and lead to a fatal Marburg hemorrhagic fever (MHF), while there is no approved vaccine or antiviral treatment for MHF. The nucleic acid vaccine has unique advantages, including fast and simple preparation, easy to follow the virus mutation situation, and less adverse reactions. Therefore, we constructed the DNA and mRNA candidate vaccines based on codon-optimized MARV glycoprotein sequence, and evaluated the immune effect in mice through ELISA, ELISpot, and Flow cytometry.

Cross-Linked Polyamide-Integrated Argyrodite LiPSCl for All-Solid-State Lithium Metal Batterie.

Lithium dendrite growth has become a significant barrier to realizing high-performance all-solid-state lithium metal batteries. Herein, an effective approach is presented to address this challenge through interphase engineering by using a cross-linked polyamide (negative electrostatic potential) that is chemically anchored to the surface of LiPSCl (positive electrostatic potential). This method improves contact between electrolyte particles and strategically modifies the local electronic structure at the grain boundary.

Lysosome-Associated Membrane Protein Targeting Strategy Improved Immunogenicity of Glycoprotein-Based DNA Vaccine for Marburg Virus.

Marburg hemorrhagic fever (MHF) is a fatal infectious disease caused by Marburg virus (MARV) infection, and MARV has been identified as a priority pathogen for vaccine development by the WHO. The glycoprotein (GP) of MARV mediates viral adhesion and invasion of host cells and therefore can be used as an effective target for vaccine development. Moreover, DNA vaccines have unique advantages, such as simple construction processes, low production costs, and few adverse reactions, but their immunogenicity may decrease due to the poor absorption rate of plasmids.

[Retracted] MicroRNA‑519 enhances HL60 human acute myeloid leukemia cell line proliferation by reducing the expression level of RNA‑binding protein human antigen R.

Following the publication of this paper, it was drawn to the Editor's attention by a concerned reader that certain of the flow cytometric analysis data shown in Fig. 4B on p. 7834 were strikingly similar to data that had already been submitted for publication in different form in another article written by different authors at different research institutes.

Numerical Analysis of Concrete Hydration Heat Impact on Frozen Soil Temperature around Cast-in-Place Piles.

The hydration heat generated during the concreting of cast-in-place piles causes thermal disturbance to the surrounding permafrost, leading to its thawing. This further affects the stability of the pile foundation and degrades the construction progress. To explore the influence mechanisms of the concrete hydration heat on the permafrost temperature field around the pile, as well as that of different construction seasons on the pile-side boundary conditions and permafrost temperature field, monitoring results of on-site tests and numerical simulation were used to analyze the distribution law of the pile soil temperature field in space and time, and the pile-side boundary conditions and permafrost temperature field during construction seasons.

The JNK/P38 signalling pathway activated by testin protects the intestinal epithelial barrier against Crohn's disease-like colitis.

The unknown mechanism that controls intestinal barrier dysfunction in individuals with Crohn's disease (CD) plays a crucial role in the onset of intestinal inflammation. Testin, an intercellular linker protein, has the potential to protect epithelial barrier function. This study aimed to analyse the effects of Testin on CD-like colitis and explore the possible underlying mechanism.

DNA Vaccines Encoding HTNV GP-Derived Th Epitopes Benefited from a LAMP-Targeting Strategy and Established Cellular Immunoprotection.

Vaccines has long been the focus of antiviral immunotherapy research. Viral epitopes are thought to be useful biomarkers for immunotherapy (both antibody-based and cellular). In this study, we designed a novel vaccine molecule, the Hantaan virus (HTNV) glycoprotein (GP) tandem Th epitope molecule (named the Gnc molecule), in silico.

[Bi{RuPPh}]: Paramagnetic 13-Vertex Polybismuthide Heteroanion.

Ru(PPh)Cl reacts with Bi from an ethylenediamine (en) solution of KBi to yield a new architype of 13-vertex [Bi{RuPPh}] () composed of unprecedented incomplete cuboidal Bi and triangular Bi held together by {RuPPh}.

Ginkgetin improved experimental colitis by inhibiting intestinal epithelial cell apoptosis through EGFR/PI3K/AKT signaling.

Excessive apoptosis of intestinal epithelial cells leads to intestinal barrier dysfunction, which is not only one of the pathological features of inflammatory bowel disease (IBD) but also a therapeutic target. A natural plant extract, Ginkgetin (GK), has been reported to have anti-apoptotic activity, but its role in IBD is unknown. This study aimed to explore whether GK has anti-colitis effects and related mechanisms.

Building Vulnerability to Landslides: Broad-Scale Assessment in Xinxing County, China.

This study develops a model to assess building vulnerability across Xinxing County by integrating quantitative derivation with machine learning techniques. Building vulnerability is characterized as a function of landslide hazard risk and building resistance, wherein landslide hazard risk is derived using CNN (1D) for nine hazard-causing factors (elevation, slope, slope shape, geotechnical body type, geological structure, vegetation cover, watershed, and land-use type) and landslide sites; building resistance is determined through quantitative derivation. After evaluating the building susceptibility of all the structures, the susceptibility of each village is then calculated through subvillage statistics, which are aimed at identifying the specific needs of each area.

A non-invasive osteopontin-targeted phase changeable fluorescent nanoprobe for molecular imaging of myocardial fibrosis.

Due to the elevated fatality rate of cardiovascular diseases, myocardial fibrosis emerges as a prominent pathological alteration in the majority of heart ailments and their associated pathologies, thereby augmenting the likelihood of sudden cardiac death. Consequently, the prompt and obligatory identification of myocardial fibrosis assumes paramount importance in averting malignant incidents among patients afflicted with cardiac disorders. Herein, with higher expression osteopontin (OPN) found in cardiac fibrosis tissue, we have developed a dual-modality imaging probe, namely OPN targeted nanoparticles (OPN@PFP-DiR NPs), which loaded perfluoropentane (PFP) for ultrasound (US) and 1,1-dioctadecyl-3,3,3,3-tetramethylindotricarbocyanine iodide (DiR) for near-infrared fluorescence (NIR) of molecular imaging, to investigate the molecular features of cardiac fibrosis using US and NIR imaging.

Effects of natural products on angiogenesis in melanoma.

Melanoma is the most aggressive form of skin cancer and originates from genetic mutations in melanocytes. The disease is multifactorial, but its main cause is overexposure to UV radiation. Currently, available chemotherapy expresses little to no results, which may justify the extensive use of natural products to treat this cancer.