Publications by authors named "Yue-ming Zhang"

Maternal separation (MS) increases the risk of occurrence of anxiety, depression, and learning and memory impairment in offspring. However, the underlying molecular biological mechanisms remain unclear. In the current study, offspring CD-1 mice were separated from their mothers from postnatal day 4 to postnatal day 21.

View Article and Find Full Text PDF

Intermittent hypoxia (IH), a major pathophysiologic alteration in obstructive sleep apnea syndrome (OSAS), is an important contributor to cognitive impairment. Increasing research suggests that melatonin has anti-inflammatory properties and improves functions related to synaptic plasticity. However, it is unclear whether melatonin has a protective effect against OSAS-induced cognitive dysfunction in aged individuals and the involved mechanisms are also unclear.

View Article and Find Full Text PDF

Introduction: Pregnant women may need to undergo non-obstetric surgery under general anesthesia owing to medical needs, and pregnant women frequently experience sleep disturbances during late gestation. Preclinical studies demonstrated that maternal isoflurane exposure (MISO) or maternal sleep deprivation (MSD) contributed to cognitive impairments in offspring. Research studies in mice have revealed that SD can aggravate isoflurane-induced cognitive deficits.

View Article and Find Full Text PDF
Article Synopsis
  • - Maternal sleep deprivation (MSD) negatively impacts learning and memory in offspring by causing inflammation and synaptic issues in the hippocampus; melatonin (Mel) is proposed as a potential remedy.
  • - In a study, mice subjected to MSD received melatonin injections, and their cognitive abilities were assessed through the Morris water maze and inflammatory markers were measured.
  • - Results showed that melatonin improved learning and memory in the affected mice by reducing inflammation and restoring synaptic plasticity markers, suggesting it could be a beneficial treatment for MSD-induced cognitive impairments.
View Article and Find Full Text PDF
Article Synopsis
  • - The study investigates the effects of Elamipretide (SS-31), a targeted antioxidant, on cognitive impairment caused by chronic sleep deprivation (CSD) in mice, highlighting its potential to address mitochondrial dysfunction and inflammation.
  • - Mice undergoing CSD for 21 days received SS-31 injections, and their cognitive functions were assessed through various tests, while biochemical assays analyzed the impact on mitochondrial and inflammatory markers.
  • - Results showed that SS-31 improved cognitive function by enhancing levels of proteins linked to synaptic function and reducing inflammation, suggesting it combats CSD-related cognitive issues by boosting SIRT1 expression.
View Article and Find Full Text PDF

Accumulating evidence confirms that sleep insufficiency is a high risk factor for cognitive impairment, which involves inflammation and synaptic dysfunction. Resveratrol, an agonist of the Sirt1, has demonstrated anti-inflammation and neuroprotective effects in models of Alzheimer's disease, Parkinson's disease, and schizophrenia. However, the beneficial effects of resveratrol on sleep deprivation-induced cognitive deficits and its underlying molecular mechanisms are unclear.

View Article and Find Full Text PDF
Article Synopsis
  • Early life stress from maternal sleep deprivation negatively impacts learning and memory in aged offspring mice, leading to cognitive decline and neuroinflammation.* -
  • Environmental enrichment (EE) was found to improve cognitive function and reduce harmful changes in brain protein levels and inflammation caused by maternal sleep deprivation.* -
  • The study suggests that EE may help counteract cognitive impairment in older offspring by activating the Sirt1/PGC-1α signaling pathway, indicating potential for clinical relevance.*
View Article and Find Full Text PDF

Growing evidence indicates that neuroinflammation plays a critical role in anxiety, depression, and cognitive impairment. Sleep loss disrupts the host's immune balance and increases neuroinflammation. This study explored whether chronic sleep deprivation aggravates lipopolysaccharide-induced anxiety, depression, and cognitive impairment and assessed the underlying mechanisms.

View Article and Find Full Text PDF

Maternal exposure to inflammation may represent a major risk factor for neuropsychiatric disorders with associated cognitive dysfunction in offspring in later life. Growing evidence has suggested that resveratrol exerts a beneficial effect on cognitive impairment via its anti-inflammatory and antioxidant properties and by ameliorating synaptic dysfunction. However, how resveratrol affects maternal immune activation-induced cognitive dysfunction and the underlying mechanisms are unclear.

View Article and Find Full Text PDF

Introduction: Currently, electroencephalogram (EEG)/electromyogram (EMG) system is widely regarded as the "golden standard" for sleep monitoring. Imperfectly, its invasive monitoring may somehow interfere with the natural state of sleep. Up to now, noninvasive methods for sleep monitoring have developed, which could preserve the undisturbed and naïve sleep state of mice to the greatest extent, but the feasibility of their application under different conditions should be extensive validated.

View Article and Find Full Text PDF
Article Synopsis
  • * Pregnant mice were injected with a substance (LPS) that causes inflammation and then were kept from sleeping for a while.
  • * The researchers found that the combination of inflammation and lack of sleep made the baby mice show more signs of anxiety, depression, and trouble learning than if their moms had slept well.
View Article and Find Full Text PDF

Purpose: To investigate changes and links of stress and high sleep reactivity (H-SR) on the macro-structure and orderliness of sleep and cortisol levels in good sleepers (GS).

Patients And Methods: Sixty-two GS (18-40 years old) were recruited, with 32 in the stress group and 30 in the control group. Each group was further divided into H-SR and low SR subgroups based on the Ford Insomnia Response to Stress Test.

View Article and Find Full Text PDF

Molecular surface reconfiguration strategies have been instrumental to performance improvements of halide perovskite photovoltaic applications in recent years. However, research into the optical properties of the lead-free double perovskite CsAgInCl on the complex reconstructed surface is still lacking. Here, blue-light excitation in double perovskite CsNaAgInCl with Bi doping has been successfully achieved by excess KBr coating and ethanol-driven structural reconstruction.

View Article and Find Full Text PDF
Article Synopsis
  • * Resveratrol is a substance that can help reduce anxiety and depression and has other health benefits.
  • * In the study, mice that were given resveratrol after being separated from their mothers showed less anxiety and depression, suggesting that resveratrol might help fix some of the problems caused by that separation.
View Article and Find Full Text PDF
Article Synopsis
  • Early-life stress and maternal sleep deprivation in rodents negatively impact the development of the central nervous system, leading to risks of neuropsychiatric disorders in their offspring, even into old age.
  • A study examined the effects of maternal sleep deprivation on depression and cognitive function in older CD-1 mice, finding that these mice displayed heightened depression-like behaviors and impaired cognition due to increased proinflammatory markers in the brain.
  • However, long-term exposure to an enriched environment was shown to reverse these negative effects, improving neuroinflammation and synaptic plasticity, suggesting that environmental enrichment can mitigate the adverse impacts of maternal sleep deprivation.
View Article and Find Full Text PDF

Introduction: Growing evidence clearly demonstrates that maternal rodents exposure to sleep deprivation (SD) during late pregnancy impairs learning and memory in their offspring. Epigenetic mechanisms, particularly histone acetylation, are known to be involved in synaptic plasticity, learning, and memory. We hypothesize that the cognitive decline induced by SD during late pregnancy is associated with histone acetylation dysfunction, and this effect could be reversed by an enriched environment (EE).

View Article and Find Full Text PDF

Background: It has been reported that age-associated cognitive decline (AACD) accelerated by maternal lipopolysaccharide (LPS) insult during late pregnancy can be transmitted to the second generation in a sex-specificity manner. In turn, recent studies indicated that glial cell line-derived neurotrophic factor (GDNF) and its cognate receptor (GFRα1) are critical for normal cognitive function. Based on this evidence, we aimed to explore whether Gdnf-GFRα1 expression contributes to cognitive decline in the F1 and F2 generations of mouse dams exposed to lipopolysaccharide (LPS) during late gestation, and to evaluate also the potential interference effect of pro-inflammatory cytokines.

View Article and Find Full Text PDF

Background: Inadequate sleep during pregnancy negatively affects the neural development of offspring. Previous studies have focused on the continuous sleep deprivation (CSD) paradigm, but the sleep pattern during late pregnancy is usually fragmented.

Objective: To compare the effects of CSD and fragmented sleep deprivation (FSD) in late pregnancy on emotion, cognition, and expression of synaptic plasticity-related proteins in offspring mice.

View Article and Find Full Text PDF

Introduction: Research suggests that prenatal inflammatory exposure could accelerate age-related cognitive decline that may be resulted from neuroinflammation and synaptic dysfunction during aging. Environmental enrichment (EE) may mitigate the cognitive and synaptic deficits. Neurite growth-promoting factor 2 (NGPF2) and postsynaptic density protein 95 (PSD-95) play critical roles in neuroinflammation and synaptic function, respectively.

View Article and Find Full Text PDF

Preclinical studies have clearly indicated that offspring of mothers who suffered sleep deprivation during pregnancy exhibit anxiety, depression-like behaviors, and cognitive deficits. The cognitive impairment induced by maternal sleep deprivation (MSD) is currently poorly treated. Growing evidence indicates that an enriched environment (EE) improves cognition function in models of Alzheimer's disease, schizophrenia, and lipopolysaccharide.

View Article and Find Full Text PDF

Gastric inverted hyperplastic polyp (GIHP) is a rare type of gastric polyp that has a trend of downward growth into the submucosal layer. We present a case of a heart-shaped GIHP removed by endoscopic submucosal dissection, which needs to be distinguished from gastritis cystica profunda.

View Article and Find Full Text PDF
Article Synopsis
  • * The average age of diagnosis was 59.3 years, with a notable rise in stage IV diagnoses from 13.5% to 20.5% over the study period; also, there was a shift toward more advanced diagnostic technologies such as CT and MRI, while x-ray usage decreased.
  • * Surgical treatments declined, with more patients receiving chemotherapy; average medical costs per patient rose significantly from about 47,259 to 86,709 Chinese
View Article and Find Full Text PDF

Studies have shown that gestational inflammation accelerates age-related memory impairment in mother mice. An enriched environment (EE) can improve age-related memory impairment, whereas mitochondrial dysfunction has been implicated in the pathogenesis of brain aging. However, it is unclear whether an EE can counteract the accelerated age-related memory impairment induced by gestational inflammation and whether this process is associated with the disruption of mitochondrial quality control (MQC) processes.

View Article and Find Full Text PDF

Accumulating evidence has indicated that embryonic inflammation could accelerate age-associated cognitive impairment, which can be attributed to dysregulation of synaptic plasticity-associated proteins, such as RNA-binding proteins (RBPs). Staufen is a double-stranded RBP that plays a critical role in the modulation of synaptic plasticity and memory. However, relatively few studies have investigated how embryonic inflammation affects cognition and neurobiology during aging, or how the adolescent psychosocial environment affects inflammation-induced remote cognitive impairment.

View Article and Find Full Text PDF

Background: Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is a minimally invasive technique for cytological and histological diagnosis. The objective of this study was to explore the role of cytological diagnosis in EBUS-TBNAs.

Methods: Eight hundred and thirteen consecutive cases performed EBUS-TBNA with both cytological and histological diagnoses were retrospectively reviewed.

View Article and Find Full Text PDF

A PHP Error was encountered

Severity: Warning

Message: fopen(/var/lib/php/sessions/ci_sessionie1e85veh8a3no3d2opd49mhtahksjsg): Failed to open stream: No space left on device

Filename: drivers/Session_files_driver.php

Line Number: 177

Backtrace:

File: /var/www/html/index.php
Line: 316
Function: require_once

A PHP Error was encountered

Severity: Warning

Message: session_start(): Failed to read session data: user (path: /var/lib/php/sessions)

Filename: Session/Session.php

Line Number: 137

Backtrace:

File: /var/www/html/index.php
Line: 316
Function: require_once