Publications by authors named "Yue-lan Wang"

Background: It is controversial whether the short-axis out-of-plane or long-axis in-plane approach is a better needling technique for ultrasound-guidance radial artery cannulation. We aimed to compare the efficacy and safety of the two approaches for ultrasound-guided radial artery cannulation.

Methods: A systematic search of Medline, Embase, the Cochrane Library, and Web of Science for relevant articles published until 1 May 2021 was conducted.

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Article Synopsis
  • - The study aims to compare the effects of two anesthetics, propofol and sevoflurane, on the occurrence of postoperative delirium in elderly patients after spine surgery, as delirium is a common and costly complication in this demographic.
  • - Conducted at the First Affiliated Hospital of Shandong First Medical University, 298 participants will be randomly assigned to receive either propofol infusion or sevoflurane inhalation, with the main focus on measuring delirium incidence within the first week after surgery and various secondary outcomes related to recovery.
  • - This research seeks to optimize anesthesia choices for elderly patients, potentially improving postoperative care by reducing delirium and its related complications after spine surgery.
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Mitochondrial dynamics, including continuous biogenesis, fusion, fission, and autophagy, are crucial to maintain mitochondrial integrity, distribution, size, and function, and play an important role in cardiovascular homeostasis. Cardiovascular health improves with aerobic exercise, a well-recognized non-pharmaceutical intervention for both healthy and ill individuals that reduces overall cardiovascular disease (CVD) mortality. Increasing evidence shows that aerobic exercise can effectively regulate the coordinated circulation of mitochondrial dynamics, thus inhibiting CVD development.

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Introduction: The aim of this prospective study is to evaluate the effects of combining topical airway anaesthesia with intravenous induction on haemodynamic variables during the induction period in patients undergoing cardiac surgery.

Methods And Analysis: This randomised, double-blind, controlled, parallel-group, superiority study from 1 March 2021 to 31 December 2021 will include 96 participants scheduled for cardiac surgery. Participants will be screened into three blocks (ASA II, ASA III, ASA IV) according to the American Society of Anesthesiologists (ASA) grade and then randomly allocated into two groups within the block in a 1:1 ratio.

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Postoperative cognitive dysfunction (POCD) is a common postoperative complication observed in elderly patients. However, the diagnosis of POCD is not very satisfactory as no specific biomarkers have been classified. It is necessary to identify new diagnostic markers to better understand the pathogenesis of POCD.

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Background: Ventilator-induced lung injury (VILI) is commonly associated with barrier dysfunction and inflammation reaction. Glutamine could ameliorate VILI, but its role has not been fully elucidated. This study examined the relationship between inflammatory cytokines (interleukin [IL]-6, tumor necrosis factor [TNF]-α, and IL-10) and adherens junctions (E-cadherin, p120-catenin), which were ameliorated by glutamine in VILI, both in vitro and in vivo.

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There are many risk factors for the cause of postoperative cognitive dysfunction (POCD), however, the anesthesia selection always trigger controversy for the POCD occurrence. This study aims to explore the relationship between the anesthesia and the occurrence of POCD in elder patients, and also investigate the mechanism of the POCD. One hundred elder patients with hip replacement were included in this study, which were divided into general anesthesia (GA) and epidural analgesia (EA) group.

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Objective: To investigate the relationship between post-operative cognitive dysfunction (POCD) and regional cerebral oxygen saturation (rSO2) and β-amyloid protein (Aβ) in patients undergoing laparoscopic pancreaticoduodenectomy.

Methods: Fifty patients undergoing elective laparoscopic pancreaticoduodenectomy received five groups of neuropsychological tests 1 d pre-operatively and 7 d post-operatively, with continuous monitoring of rSO2 intra-operatively. Before anesthesia induction (t0), at the beginning of laparoscopy (t1), and at the time of pneumoperitoneum 120 min (t2), pneumoperitoneum 240 min (t3), pneumoperitoneum 480 min (t4), the end of pneumoperitoneum (t5), and 24 h after surgery, jugular venous blood was drawn respectively for the measurement of Aβ by enzyme-linked immunosorbent assay (ELISA).

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Superoxide dismutase (SOD) is used to manage chronic pain, including neuropathic and inflammatory pain. However, data regarding the clinical effectiveness are conflicting and the neurophysiological mechanism of SOD has yet to be elucidated. The aim of the present study was to investigate whether SOD relieved chronic central pain (CCP) following spinal cord injury (SCI) and the possible underlying mechanisms.

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The clinical analgesic effect of electro-acupuncture (EA) stimulation (EAS) on breakthrough pain induced by remifentanil in patients undergoing radical thoracic esophagectomy, and the mechanisms were assessed. Sixty patients (ASAIII) scheduled for elective radical esophagectomy were randomized into three groups: group A (control) receiving a general anesthesia only; group B (sham) given EA needles at PC4 (Ximen) and PC6 (Neiguan) but no stimulation; and group C (EAS) electrically given EAS of the ipsilateral PC4 and PC6 throughout the surgery. The EAS consisting of a disperse-dense wave with a low frequency of 2 Hz and a high frequency of 20 Hz, was performed 30 min prior to induction of general anesthesia and continued through the surgery.

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Article Synopsis
  • p120 catenin (p120ctn) is an important protein that helps regulate cell barriers, and its loss may lead to increased permeability and alveolar edema during high lung inflation from ventilation, particularly affecting alveolar epithelial cell tight junctions.
  • In experiments, MLE12 cells showed reduced p120 levels and increased c-src activation with cyclic stretching, and similar results were observed in SD rats subjected to different tidal volumes, indicating that high tidal volume ventilation can worsen pulmonary edema.
  • Inhibiting c-src reversed the changes in both cell cultures and animal models, suggesting that maintaining p120 levels might be a promising new approach for preventing ventilation-induced lung injury (VILI).
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Objective: To observe the effect of electroacupuncture (EA) intervention on the expression of norepinephrine transporter (NET) mRNA in the middle cervical-stellate ganglion complex (MC-SGC) and beta1-adrenergic receptor (beta1-AR) mRNA in the left ventricular myocardium in cerebral-cardiac syndrome (CCS) rats, so as to study its underlying mechanism in the prevention and treatment of CCS.

Methods: Eighteen Wistar rats were randomized into sham operation, model and EA groups (n=6). CCS model was duplicated by intravenous injection of 1 microL of saline containing collagenase (1 U/microL) + heparin (7 U/microL) into the caudate nucleus.

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Objective: To observe the effect of electroacupuncture (EA) of "Shenmen" (HT 7), "Neiguan" (PC 6), etc. on monoamine neurotransmitter contents of hypothalamic paraventricular nucleus (PVN) region in myocardial ischemia (MI) rats, so as to analyze the substantial basis of efficacy specificity of acupoints in improving MI.

Methods: SD rats were randomized into normal control, model, EA-Shenmen (HT7), EA-Neiguan (PC 6) and EA-Taiyuan (LU 9) groups (n = 10/group).

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Establishing codon usage biases are crucial for understanding the etiology of central nervous system neurodegenerative diseases (CNSNDD) especially Alzheimer's disease (AD) as well as genetic factors. G and C ending codons are strongly biased in the coding sequences of these proteins as a result of genomic GC composition constraints. On the other hand, codons that identified as translationally optimal in the major trend all end in C or G, suggesting translational selection should also be taken into consideration additional to compositional constraints.

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Objective: To compare the effects of electroacupuncture (EA) of different acupoint groups on heart rate variability (HRV) and cerebral glutamate (Glu) and aspartic acid (Asp) contents in cerebrocardiac syndrome (CCS) rats.

Methods: A total of 52 Wistar rats were randomized into normal (n = 8), sham-operation (sham, n = 8), model (n = 12), Shuigou-Fengfu (GV 26-GV 16, n = 12), and Neiguan-Xinshu (PC 6-BL 15, n = 12) groups. CCS model was established by intracerebral (Caudate nucleus) injection of clostridiopeptidase (1 U/microl) plus heparin (7 U/microl).

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Objective: To study the scientific basis of specific correlation between the meridian and the Zang- or Fu organ by using gene differential expression (gene-chip technique) in the rat.

Methods: Twenty-one SD rats were randomly and evenly divided into control group, sham-myocardial ischemia (MI) group, MI group, electroacupuncture (EA)-Heart-Meridian (HT) group, EA-Lung-Meridian (LU) group and EA-Small-Intestine-Meridian (SI) group. EA (frequency 2 Hz, stimulating strength 5 V, pulse duration 300 mus) was applied to "Shenmen" (HT 7)- "Tongli" (HT 5) (Heart Meridian), "Y anglao" (SI 6)- "Zhizheng" (SI 7) (Small Intestine Meridian), "Taiyuan" (LU 9)-"Lieque" (LU 7) (Lung Meridian) for 20 min, once daily and continuously for 3 days.

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Purinergic receptors are a class of cell surface receptors for purines that prefer ATP or ADP over adenosine. The surface receptors for extracellular nucleotides are called P2 receptors. They are activated by both pyrimidine and purine nucleotides.

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Objective: To reveal the mechanism of acupuncture at the Heart meridian in treatment of myocardial ischemia from gene level.

Methods: A model of acute myocardial ischemia was made by ligation of left anterior descending branch of the coronary artery. Changes of gene expression pattern of the Lung meridian group, the Heart meridian group and the model group in the heart were compared.

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Objective: Rosiglitazone, a potent agonist of peroxisome proliferator-activated receptor (PPAR)-gamma, exerts anti-inflammatory effects in vitro and in vivo. This study was designated to determine the effects of rosiglitazone on endotoxin-induced acute lung injury in rats.

Design: Prospective, experimental study.

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In order to investigate the energy and structural character of RNA-RNA triplets and RNA-DNA duplex base triplets, 64 sets of three-dimensional models of RNA-DNA duplex base triplets and mRNA-tRNA triplex base triplets were constructed and optimized by homologous modeling method using the software InsightII. The comparative statistical method and cluster analysis were adopted to study these features. The result showed: (i) all energy parameters of monomer RNA-DNA hybrid triplets and ternary complexes appeared significantly different; and some parameters related with overall molecules such as overall energy, bond energy and coulomb energy have statistically significant correlations between the structures in vacuum and aquatic solutions while other parameters, including theta energy, phi energy, hydrogen bond energy and non-bond energy, changed significantly, but not continuously.

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