Preoperative computed tomography diagnosis of non-recurrent laryngeal nerve in patients with esophageal carcinoma.

Background: The non-recurrent laryngeal nerve (NRLN) is a rare but potentially serious anomaly that is commonly associated with the aberrant right subclavian artery (ARSA). It is easy to damage during surgical resection of esophageal cancer, leading to severe complications.

Methods: Preoperative enhanced thoracic computed tomography (CT) scans of 2697 patients with esophageal carcinoma treated in our hospital between January 2010 and December 2013 were examined.

[Dexamethasone acetate microemulsions: formulation and effect on skin permeability].

The present project was designed to optimize the microemulsion (ME) formulation of oil in water (O/W) for dexamethasone acetate (DA), and examine its impact on DA percutaneous permeation. The saturated solubility of DA in different oils, surfactants and co-surfactants was tested. The ratio of surfactant to co-surfactant was selected by constructing pseudo three phase diagrams to investigate the maximal microemulsion area.

[In vitro targeting effect of lactoferrin modified PEGylated liposomes for hepatoma cells].

A lactoferrin-containing PEGylated liposome system (Lf-PLS) was developed and tested in vitro as a hepatoma-targeting drug delivery system. PEGylated liposomes (PLS) were successfully prepared using the thin film hydration method with peglipid post insertion. Lf was covalently conjugated onto the carboxyl terminal of DSPE-PEG2000-COOH on liposomes.

[Diagnostic Value of (18)F-FDG-PET/CT for Multiple Myeloma].

Objective: To study the diagnostic value of (18)F-FDG-PET/CT in multiple myeloma (MM).

Methods: A total of 66 patients, who were highly suspected of MM in our hospital from July 2012 to December 2014, were chosen as study objects. All patients were diagnosed or excluded by pathological examination.

Plasma pharmacokinetics and lung distribution of tetrahydropalmatine after topical application of cold asthma recipe extract: Feishu (BL 13) versus Non-Feishu acupoint.

Ethnopharmacological Relevance: Acupoint application of cold asthma recipe (CAR) was a traditional Chinese medicine (TCM) method, widely used as an alternative medicine for clinical prevention of the common winter diseases of asthma and bronchitis. Tetrahydropalmatine (THP) was a main active ingredient of CAR extract. The aim of this study is to compare plasma pharmacokinetics and lung distribution of THP between Feishu (FS) acupoint (BL 13) and Non-Feishu (NFS) acupoint application of CAR extract by ultra performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS).

Antidiarrheal properties of different extracts of Chinese herbal medicine formula Bao-Xie-Ning.

Objective: Bao-Xie-Ning (BXN), a traditional Chinese herbal medicine (CHM) formula composed of Fructus Evodiae, Flos Caryophylli and Cortex Cinnamomi, and used for the treatment of infant diarrheal illness, was subject to systematic assessment for its putative multiple pharmacodynamic effects and pharmacological antidiarrheal mechanisms.

Methods: High-performance liquid chromatography-diode array detector-electrospray ionization-mass spectrometric/mass spectrometry was developed and validated for identification and quantification of the main constituents in different extracts of BXN. Male Kunming mice weighing 20 to 25 g were used for detecting the antidiarrheal activity of the extracts.

[In vivo imaging in tumor-bearing animals and pharmacokinetics of PEGylated liposomes modified with RGD cyclopeptide].

The hydroxycamptothecin (HCPT) PEGylated liposomes (HCPT-LP) were modified with RGD cyclopeptide formed the tumor-targeting liposomes (HCPT-RGD-LP). HCPT-LP and HCPT-RGD-LP were injected intravenously with single dose of 5 mg x kg(-1) to rats. The drug concentration in plasma was determined and the pharmacokinetic behaviour was compared.

In vitro study of transdermal penetration and iontophoresis of hepatitis B vaccines through rat skin.

In vitro percutaneous delivery of hepatitis B vaccines was investigated in order to assess the penetration of vaccine under passive diffusion and iontophoresis conditions. The study was carried out using Franz vertical diffusion cell through the hairless abdominal skin of Sprague-Dawley (SD) rats. Enzyme-linked immunosorbent assay (ELISA) was used to determine the cumulative amount of permeation and the retention amount of drug in skin.

Effect of composite salvia injection on platelet parameters in children with anaphylactoid purpura.

Objective: To explore the effect of composite salvia injection (CSI) on platelet parameters in children with anaphylactoid purpura (AP) and its clinical significance.

Methods: One hundred and fifty children with AP were assigned to two groups, 80 in Group A and 70 in Group B. They were treated, respectively, with conventional therapy only or conventional therapy combined with CSI.

[Effect of atractylodes rhizome oil and other volatile oils on percutaneous absorption of baicalin].

Objective: To study the effects of atractylodes rhizome oil, patchouli oil, angelica volatile oil on the transdermal delivery of baicalin.

Methods: The modified Valia-Chien diffusion cells was used. With saline isotonic solution as receptor fluid and different concentration of atractylodes rhizome oil, patchouli oil, angelica volatile oil as enhancers, the cumulative amount of baicalin penatrating through the skin was determined in vitro.

[Optimization of ligustrazine phosphate thermosensitive gel formulation by central composite design-response surface methodology].

Objective: To optimize the formulation of ligustrazine phosphate thermosensitive gel by the central composite design-response surface methodology (RSM plus CCD).

Methods: In the formulation design using RSM plus CCD, independent variables were the amounts of poloxamer 407 and poloxamer 188, and gel temperature was dependent variable. Multilinear and quadratic models were used to estimate the relationship between the dependent and the independent variables, select the optimal formulations and validate.

[Preparation of docetaxel liposomes and their pharmacokinetics in rabbits].

Background & Objective: Docetaxel is used to treat non-small cell lung cancer, breast cancer and ovarian cancer. It is indissolvable and the solvent containing polysorbate-80 and 13% solution of ethanol is used for injections. Its clinical application is limited because of frequent severe hypersensitive responses.

[Effect of micronization on the quality of Salvia miltiorrhiza Bge].

Objective: The powder characteristic, water extraction amount and active ingredients cryptotanshinone (CTS), tanshinone II A (TS) and protocaechuic aldehyde (PA) were comparatively studies between crude powder and micronized powder to study the application of micronization technology to Salvia miltiorrhiza Bge.

Methods: Salvia miltiorrhiza Bge powedr was characterized by laser diffraction analyzer and scanning electron microscopy. The angle of repose and bulk density was measured.

[Solubilization on cryptotanshinone by hydroxypropyl-beta-cyclodextrin and preparation of their inclusion compound].

Objective: To prepare cryptotanshinone (CT)-cyclodextrin inclusion compound and improve dissolution of CT.

Method: Inclusion ratio was determined by plotting the phase solubility curve of CT versus hydroxypropyl-beta-cyclodextrin (HPCD). CT-cyclodextrin inclusion compound was made by wet grinding method.

[Review and analysis of present status of the micronization of Chinese traditional medicine].

Micronization is one of the methods to improve the solubility and bioavailability of drug, the micronization of TCM is a new techonology of TCM mordenization. status in quo of TCM micronization was reviewed and analyzed. Effects of micronization on the dissolution of active ingredients and pharmacological action were widely studied, however some fundmental aspects, such as engineering factors of superfine powder preparation, stability of them and the optimal particle size, are urgently to be studied.