Coordination of LMO7 with FAK Signaling Sustains Epithelial Integrity in Renal Epithelia Exposed to Osmotic Pressure.

The kidney epithelial barrier has multifaceted functions in body fluids, electrolyte homeostasis, and urine production. The renal epithelial barrier (REB) frequently faces and challenges osmotic dynamics, which gives rise to osmotic pressure (a physical force). Osmotic pressure overloading can crack epithelial integrity and damage the REB.

[Prognostic Value of Average Daily Platelet Increase in Childhood B-cell Acute Lymphoblastic Leukemia Patients].

Objective: To evaluate the prognosis value of average daily platelet amount increase in children with B-cell acute lymphoblastic leukemia(B-ALL) treated by CCCG-ALL-2015 regimen.

Methods: 106 children with primary B-ALL were retrospective analyzed, standardized MRD test protocol was used to detect the MRD level (19 d and 46 d) after chemotherapy. The platelet count was measured by Sysmex XE-2100.

[Relationship between Immune Differentiation Antigen and Minimal Residual Disease in Childhood B-ALL].

Objective: To determine whether immune differentiation antigen is related with clinical features and minimal residual disease (MRD) in childhood B-cell precursor acute lymphoblastic leukemia (B-ALL), who were treated with CCCG-ALL-2015 protocol.

Methods: A retrospective analysis was conducted in 132 B-ALL children, Multiparametric flow cytometry was used to analyze the immunophenotypes. The children were divided into 2 groups by MRD>0.

Prospective, sequential, longitudinal study of coagulation changes during pregnancy in Chinese women.

Objective: To investigate changes and establish reference values for coagulation variables during normal pregnancy and after delivery in Chinese women.

Methods: A prospective, sequential, longitudinal study with strict inclusion and exclusion criteria was performed with 232 Chinese women.

Results: Prothrombin time, international normalized ratio, activated partial thromboplastin time, and activated partial thromboplastin time ratio were shorter, and platelet count decreased gradually during pregnancy, with no change in mean platelet volume; conversely, plasma concentration of both fibrinogen and fibrin/fibrinogen degradation product increased.