Publications by authors named "Yue-dong Ma"
Article Synopsis
- * An observational study of 15,792 individuals found that low serum potassium and magnesium levels were associated with a higher risk of AF, while increased phosphate levels were also linked to greater incidence, but calcium levels showed no correlation.
- * Despite these associations, the study concluded that serum electrolytes are not causal factors for AF development, suggesting they could be used as prognostic indicators rather than direct causes.
Article Synopsis
- The study aimed to evaluate the safety of MRI procedures in patients with epicardial cardiac implantable electronic devices (CIEDs) due to existing uncertainties around risks.
- Researchers monitored patients with epicardial CIEDs during MRI scans over a span of 13 years to compare outcomes with those having non-MRI-conditional transvenous CIEDs.
- The findings indicated no significant adverse effects from the MRIs, suggesting that epicardially implanted leads do not pose additional risks when safety protocols are properly followed.
Right ventricular pacing often results in prolonged QRS duration (QRSd) as the result of right ventricular stimulation, and atrial fibrillation (AF) may result. The association of pacing-induced prolonged QRSd and AF in patients with permanent pacemakers is unknown.We selected 180 consecutive patients who underwent pacemaker implantation for complete/advanced atrioventricular block.
View Article and Find Full Text PDF[Effects of AMPK on the transcriptional activity of FOXO1 and ubiquitin ligase MuRF1 expression in rat cardiomyocytes].
Nan Fang Yi Ke Da Xue Xue Bao
November 2010
Objective: To investigate the effects of AICAR on the activity of transcription factor FOXO1 and expression of ubiquitin ligase MuRF1 in rat cardiomyocytes, and explore the possible role of AMP-activated protein kinase (AMPK) in proteolysis pathways.
Methods: In vitro cultured neonatal rat cardiac myocytes were treated with AICAR, and Western blotting was used to detect the phosphorylation of FOXO1 and expression of MuRF1 in the cells.
Results: AICAR activated AMPK in rat cardiac myocytes.
1. Metformin is an activator of AMP-activated protein kinase (AMPK). Recent studies suggest that pharmacological activation of AMPK inhibits cardiac hypertrophy.
View Article and Find Full Text PDFAim: To examine the inhibitory effects of adenosine monophosphate-activated protein kinase (AMPK) activation on cardiac hypertrophy in vitro and to investigate the underlying molecular mechanisms.
Methods: Cultured neonatal rat cardiomyocytes were treated with the specific AMPK activator 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR) and the specific AMPK antagonist Compound C, and then stimulated with phenylephrine (PE). The Muscle RING finger 1 (MuRF1)-small interfering RNA (siRNA) was transfected into cardiomyocytes using Lipofectamine 2000.
Article Synopsis
- Rosiglitazone, commonly used to treat Type 2 diabetes, has been found to provide cardioprotection against ischemia-reperfusion (I/R) injury, though the exact mechanisms were previously unclear.
- A study showed that mice pretreated with rosiglitazone exhibited less heart damage and reduced cardiac cell death after I/R, and the phosphatidylinositol 3-kinase (PI3-K)/Akt signaling pathway played a crucial role in this protective effect.
- Inhibition of the PI3-K pathway using wortmannin negated the cardioprotective benefits of rosiglitazone, highlighting its importance as a potential therapeutic target for reducing myocardial I/R injury.
[Report of two cases with lamivudine-caused extrapyramidal reaction].
Zhonghua Er Ke Za Zhi
June 2004