Silencing FUT4 Inhibits the Progression of Osteosarcoma through Activation of FOXO1.

Background: It has been reported that inhibition of Fucosyltransferase4 (FUT4) to activate Forkhead box O1 (FOXO1) can lead to apoptosis of cancer cells, however, the mechanism in osteosarcoma is still unclear.

Objective: To explore the biological significance of the connection between FUT4 and FOXO1 in osteosarcoma growth.

Methods: In vitro tests were conducted using the human osteoblast cell line and the osteosarcoma cell lines.

The Effect of Task Interruption on Working Memory Performance.

Objective: This study used electroencephalography to explore the behavioral and electrophysiological effects of task interruption on performance.

Background: Task interruption is known to harm work performance, especially on working memory-related tasks. However, most studies pay little attention to cognitive processes by exploring brain activity and ignore the cumulative effect of sequential interruptions.

Vicenin 3 ameliorates ECM degradation by regulating the MAPK pathway in SW1353 chondrocytes.

Aberrant destruction of the articular extracellular matrix (ECM) has been considered to be one of the pathological features of osteoarthritis (OA) which results in chondrocyte changes and articular cartilage degeneration. The MAPK signaling pathway serves a key role by releasing cartilage-degrading enzymes from OA chondrocytes. However, the use of MAPK inhibitors for OA is hindered by their potential long-term toxicity.

Phenolic Compounds from the Leaves of Castanopsis fargesii.

In the course of a phytochemical and chemotaxonomical investigation of species (Fagaceae), three new phenolic compounds, (3,1')-[1'-(6″--galloyl-β-d-gluco-pyranosyl)oxyethyl]-3-hydroxy-dihydrofuran-2(3)-one (), (2,3)-2-[2'-(galloyl)oxyethyl]-dihydroxybutanoic acid (), and (3,4)-3-hydroxymethyl-3,4-dihydro-5,6,7-trihydroxy-4-(4'-hydroxy-3'-methoxyphenyl)-1-[2]-benzopyran-1-one () were isolated from the fresh leaves of . In addition, a known phenolic glycoside, gentisic acid 5--α-l-rhamnopyranosyl-(1→2)-β-d-glucopyranoside () was also isolated and identified. Their structures were elucidated by means of spectroscopic methods including one- and two-dimensional NMR techniques.

New pregnane glycosides from Brucea javanica and their antifeedant activity.

Three new pregnane glycosides, 3-O-β-D-glucopyranosyl-(1→2)-α-L-arabinopyranosyl-(20R)-pregn-5-ene-3β,20-diol (1), 3-O-α-L-arabinopyranosyl-(20R)-pregn-5-ene-3β,20-diol-20-O-β-D-glucopyranoside (2), 3-O-α-L-arabinopyranosyl-(20R)-pregn-5-ene-3β,20-diol-20-O-β-D-glucopyranosyl-(1→2)-β-D-glucopyranoside (3) were isolated along with four known compounds, 4-7, from the leaves and stems of Brucea javanica. Their structures were determined by detailed analyses of 1D- and 2D-NMR spectroscopic data. All of the compounds isolated from Brucea javanica were tested for the antifeedant activities against the larva of Pieris rapae.