Publications by authors named "Yue-Yu Zheng"
Article Synopsis
- The study investigates the expression and clinical significance of Cav3.1, a T-type calcium channel, in oral squamous cell carcinoma (OSCC), revealing its higher levels in cancerous tissues compared to normal and dysplastic oral mucosa.
- Researchers used techniques like real-time PCR, Western blotting, and immunohistochemistry on tissue samples, finding strong correlation between Cav3.1 expression and tumor size, grade, and markers related to cell proliferation and survival.
- Further functional assays showed that reducing Cav3.1 levels in OSCC cells impacted their growth and resistance to apoptosis, highlighting its potential role in tumor progression.
Leukocyte‑derived microparticles (LMPs) include neutrophil‑, lymphocyte‑ and monocyte‑derived MPs. LMPs act as proinflammatory mediators in autoimmune diseases, infectious diseases and vascular diseases. The present study examined the hypothesis that the percentage of LMPs was increased in patients with inflamed odontogenic keratocysts (OKCs), and investigated the biological effects of Jurkat cell‑derived MPs on the fibroblasts of OKCs in vitro.
View Article and Find Full Text PDFAims: The purpose of this study was to explore the potential involvement of Fra-1, c-Jun and c-Fos, three vital members of the AP-1 complex, in the pathogenesis of odontogenic keratocysts (OKCs).
Methods And Results: Tissue samples, containing 10 normal oral mucosa (OM), 10 dentigerous cysts (DC) and 32 OKC specimens, were applied to investigate the expression levels of Fra-1, c-Jun and c-Fos by immunohistochemistry and real-time-quantitative polymerase chain reaction (RT-qPCR). The association between Fra-1, c-Jun and c-Fos expression levels and markers of proliferation [Ki-67, proliferating cell nuclear antigen (PCNA)], anti-apoptosis (Bcl-2) was then investigated in the OKC serial tissue sections.
Article Synopsis
- * Results showed that CFMPs were significantly more abundant in OKCs compared to other types of cysts (dentigerous and radicular cysts) and could influence bone resorption as indicated by in vitro experiments with mouse bone marrow-derived macrophages (BMMs).
- * The research also found that CFMPs from OKCs led to increased expression of specific genes related to osteoclastogenesis, suggesting a connection between these microparticles and the bone remodeling processes associated with OKCs.