New nurses' turnover intention and clinical belonging, based on latent class analysis (LCA).

Aim: To identify potential categories of clinical belonging among new nurses and explore the relationship between different categories and turnover intention.

Design: A cross sectional study.

Method: A cross sectional study was conducted among 348 new nurses from tertiary hospitals in Hainan and Guangdong provinces.

The Efficacy of Everolimus for Facial Angiofibromas in Tuberous Sclerosis Complex Patients Treated for Renal Angiomyolipoma/Subependymal Giant Cell Astrocytoma.

Background: Facial angiofibromas may be present since early childhood in individuals with tuberous sclerosis complex (TSC), causing substantial cosmetic disfigurement. Current therapies are partially effective, but they are uncomfortable, produce scarring, and are especially expensive.

Objective: The aim of the present study was to evaluate the efficacy of oral everolimus for TSC-associated angiofibromas.

The Association Between Usage of Colchicine and Pneumonia: A Nationwide, Population-Based Cohort Study.

A previous study suggested that colchicine may cause leukopenia and increase the risk of infection, such as pneumonia. Thus, we investigated the potential relationship between colchicine use and risk of developing pneumonia. Data were collected from Taiwan's National Health Insurance Research Database (NHIRD), a nationwide, population-based database.

Azathioprine hepatotoxicity and the protective effect of liquorice and glycyrrhizic acid.

This study aimed to evaluate the responses of human hepatocytes to azathioprine hepatotoxicity in comparison with the well-studied azathioprine hepatotoxicity in rat hepatocytes and the effects of protective agents to suppress azathioprine hepatotoxicity. Azathioprine presented its hepatotoxicity at clinically relevant concentrations (lower than 10 microm) in primary rat hepatocytes after 48 h of treatment as shown by a severe decrease in cell viability as well as intracellular GSH depletion. However, primary human hepatocytes exhibited only significant intracellular GSH depletion after treatment with azathioprine at these clinically relevant concentrations, while a reduction in cell viability by 29% was only evidenced after 48 h of treatment with azathioprine at the high concentration of 50 microm.

Biodegradation of crude oil by Pseudomonas aeruginosa in the presence of rhamnolipids.

The potential biodegradation of crude oil was assessed based on the development of a fermentative process with a strain of Pseudomonas aeruginosa which produced 15.4 g/L rhamnolipids when cultured in a basal mineral medium using glycerol as a sole carbon source. However, neither cell growth nor rhamnolipid production was observed in the comparative culture system using crude oil as the sole carbon source instead.