Publications by authors named "Yue-Ming Chu"
Front Cell Dev Biol
March 2023
Article Synopsis
- Oncogenes, like the Holliday Junction Recognition Protein (HJURP), play a significant role in cancer development, acting as a chaperone for histone H3 and influencing nucleosome composition.
- HJURP is found on chromosome 2q37.1 and is crucial for assembling centromere structures, with its dysfunction linked to tumorigenesis and poor cancer prognosis.
- Research indicates that HJURP is often overexpressed in various cancers, promoting cell proliferation and invasiveness, making it a potential target for innovative cancer therapies.
