Publications by authors named "Yue-Miao Hu"
Biochem Pharmacol
July 2024
Article Synopsis
- Targeting the DNA damage response (DDR) is effective in cancer therapy, especially since tumor cells often struggle with damage repair due to defects.
- The study focuses on the role of the ATR protein as a potential target, showing that inhibiting ATR can decrease DNAPKcs and downregulate the retinoblastoma (RB) protein, leading to issues during the G1/S-phase transition in cancer cells.
- The research highlights that damaging four-way DNA Holliday junctions can halt the cell cycle and cause lethal damage in triple-negative breast cancer (TNBC) cells, suggesting a novel strategy for treatment by interfering with DDR pathways.
