SARS-CoV-2 specific adaptations in N protein inhibit NF-κB activation and alter pathogenesis.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and severe acute respiratory syndrome coronavirus (SARS-CoV) exhibit differences in their inflammatory responses and pulmonary damage, yet the specific mechanisms remain unclear. Here, we discovered that the SARS-CoV-2 nucleocapsid (N) protein inhibits the activation of the nuclear factor-κB (NF-κB) pathway and downstream signal transduction by impeding the assembly of the transforming growth factor β-activated kinase1 (TAK1)-TAK1 binding protein 2/3 (TAB2/3) complex. In contrast, the SARS-CoV N protein does not impact the NF-κB pathway.

Life course patterns of work history and cognitive trajectories among community-dwelling older adults.

Objectives: Prior research indicated that diverse work experiences in early and middle life stages are associated with cognitive function in later life. However, whether life course patterns of work history are associated with later life cognitive function in China remains unknown.

Methods: Data were derived from the China Health and Retirement Longitudinal Study, and 5,800 participants aged 60 years or older were included.

A Novel Shear-Detachment Approach for Modeling Dynamics of Membrane Cleaning.

We report a novel shear-detachment (SD) approach to simulate the dynamics of flux recovery in the membrane cleaning process. In this model, the rate of foulant detachment away from the membrane is governed by both the shear intensity and the probability of successful foulant detachment, with the latter modeled by Boltzmann distribution. Our SD predictions exhibit good agreement with experimental results, accurately capturing the dynamics of flux recovery.

Association Between Chronic Obstructive Pulmonary Disease and Mortality in Participants with Arthritis: Data from the National Health and Nutrition Examination Survey 1999-2018.

Objective: Chronic obstructive pulmonary disease (COPD) is closely associated with arthritis. This study aims to evaluate the correlation between COPD and mortality among participants with arthritis.

Methods: The study included 11,298 participants from the National Health and Nutrition Examination Survey (NHANES) 1999-2018, who self-reported having arthritis.

GS-4997 halts the progression of tubulointerstitial injury in lupus nephritis.

Tubulointerstitial injury has been increasingly recognized as an important component in lupus nephritis (LN) pathology over the last decades. However, current clinical treatment options for this process remain limited. In this study, we aimed to investigate the potential benefits of GS-4997, a selective inhibitor of ASK1, in tubulointerstitial injury of LN.

3D Ordered Macroporous Mn, Zr-Doped CaCO Nanomaterials for Stable Thermochemical Energy Storage.

Developing high-performance Ca-based materials that can work for long-term heat transfer and storage in concentrated solar power plants is crucial to achieve the large-scale conversion of solar photon fluxes to dispatchable electricity. This work demonstrates that a series of Mn, Zr co-doped CaCO nanomaterials with the 3D ordered macroporous (3DOM) skeletons are successfully prepared by a novel strategy of templated metal salt co-precipitation. The characterization results indicate that a majority of Zr and Mn are atomically dispersed into the highly-crystallized CaCO framework, whereas a minor amount of Mn is present in the form of CaMnO nanoparticles (NPs).

Cellulose Acetate Membranes: Antibacterial Strategy and Application-A Review.

Developing antibacterial and biodegradable cellulose acetate (CA) membrane materials is one of the main challenges in multiple application fields. CA membrane materials are widely used in gas purification, water purification, and biomedical fields due to their environmental friendliness, high chemical and mechanical stability, excellent processability, and low cost. However, antibacterial modification of CA membrane materials to enhance their utilization value in the application process has always been the direction of researchers' efforts.

Recent developments in isothermal amplification technology for rapid detection of SARS-CoV-2.

Coronavirus disease 2019 (COVID-19), an infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has spread globally, posing a significant threat to human health. Rapid and accurate detection of infectious disease pathogens is of crucial practical significance for early screening, timely intervention, and outbreak prevention. However, conventional diagnostic methods are increasingly unable to meet clinical demands.

Interface engineering for photoelectrochemical oxygen evolution reaction.

Photoelectrochemical (PEC) water splitting provides a promising approach for solving sustainable energy challenges and achieving carbon neutrality goals. The oxygen evolution reaction (OER), a key bottleneck in the PEC water-splitting system occurring at the photoanode/electrolyte interface, plays a fundamental role in sustainable solar fuel production. Proper surface or interface engineering strategies have been proven to be necessary to achieve efficient and stable PEC water oxidation.

Structural diversity of Alzheimer-related protein aggregations revealed using photothermal ratio-metric micro-spectroscopy.

The crucial link between pathological protein aggregations and lipids in Alzheimer's disease pathogenesis is increasingly recognized, yet its spatial dynamics remain challenging for labeling-based microscopy. Here, we demonstrate photothermal ratio-metric infrared spectro-microscopy (PRISM) to investigate the structural and molecular compositions of pathological features in brain tissues at submicron resolution. By identifying the vibrational spectroscopic signatures of protein secondary structures and lipids, PRISM tracks the structural dynamics of pathological proteins, including amyloid and hyperphosphorylated Tau (pTau).

Effects of pharmacogenomics-guided treatment on medication adherence and the antidepressant switching rate in major depressive disorder.

Background: In the treatment of depression, medication plays a crucial role. However, insufficient patient adherence to medication often results in unsatisfactory treatment outcomes, increasing both the recurrence and rehospitalization rates of depression, and consequently imposing a greater economic burden on the healthcare system.

Objectives: Our objective was to examine the impact of pharmacogenomic testing on medication adherence and antidepressant switching rates among individuals diagnosed with depression.

Eugenol Nanoparticles Ameliorate Doxorubicin-Induced Spermatogenic Dysfunction by Inhibiting the PINK1/Parkin and BNIP3/NIX Signaling Pathways.

Purpose: Doxorubicin (DOX) precipitates cell apoptosis in testicular tissues, and it is imperative to develop drugs to alleviate the spermatogenic disorders it causes. Thunb is often used to treat male sexual disorders. Eugenol, a major component of Thunb.

Unleashing the potential: AI empowered advanced metasurface research.

In recent years, metasurface, as a representative of micro- and nano-optics, have demonstrated a powerful ability to manipulate light, which can modulate a variety of physical parameters, such as wavelength, phase, and amplitude, to achieve various functions and substantially improve the performance of conventional optical components and systems. Artificial Intelligence (AI) is an emerging strong and effective computational tool that has been rapidly integrated into the study of physical sciences over the decades and has played an important role in the study of metasurface. This review starts with a brief introduction to the basics and then describes cases where AI and metasurface research have converged: from AI-assisted design of metasurface elements up to advanced optical systems based on metasurface.

A survey on multimodal large language models.

Recently, the multimodal large language model (MLLM) represented by GPT-4V has been a new rising research hotspot, which uses powerful large language models (LLMs) as a brain to perform multimodal tasks. The surprising emergent capabilities of the MLLM, such as writing stories based on images and optical character recognition-free math reasoning, are rare in traditional multimodal methods, suggesting a potential path to artificial general intelligence. To this end, both academia and industry have endeavored to develop MLLMs that can compete with or even outperform GPT-4V, pushing the limit of research at a surprising speed.

PPIH Expression Correlates with Tumor Aggressiveness and Immune Dysregulation in Hepatocellular Carcinoma.

Purpose: Hepatocellular Carcinoma (HCC) features a complex pathophysiology and unpredictable immunosuppressive microenvironment, which limit the effectiveness of traditional therapies and lead to poor patient outcomes. Understanding the immune characteristics of HCC is essential for elucidating the immune microenvironment and developing more effective treatments. This study investigates the role of Peptidyl-prolyl isomerase H (PPIH) in HCC by analyzing its expression, prognosis, methylation levels, and relationship with immune cell infiltration.

17-hydroxy-jolkinolide B potentiated CTLA4ab therapy through targeting tumor suppression and immune activation by downregulating PD-L1 expression in lung adenocarcinoma.

Background: 17-hydroxy-jolkinolide B (HJB) is a natural diterpenoid compound derived from plants of the family that has anticancer properties against various types of tumors. However, its action and underlying mechanism in lung adenocarcinoma (LUAD) progression remain largely unknown. Thus, this research aimed to explore the role of HJB in LUAD pathogenesis and its clinical significance in tumor therapy.

Safety and efficacy of percutaneous mechanical thrombectomy in the treatment of acute medium- or high-risk pulmonary embolism: a single-center retrospective cross-sectional study.

Background: Patients with acute and high-risk pulmonary embolism have a high mortality rate, and the optimal treatment for these patients has still not been fully established. Although anticoagulation therapy is currently the preferred treatment for pulmonary embolism, for some patients with intermediate- or high-risk pulmonary embolism, anticoagulation therapy alone has a higher probability of long-term pulmonary hypertension and also seriously worsens the quality of life of patients. This paper mainly reports the efficacy and safety of percutaneous mechanical thrombectomy (PMT) in patients with acute medium- or high-risk pulmonary embolism in Taizhou Hospital of Zhejiang Province so as to provide some clinical basis for the treatment of such patients in the future.

Farnesoid X receptor (FXR) as a potential therapeutic target for lung diseases: a narrative review.

Background And Objective: Farnesoid X receptor (FXR), which is encoded by the gene, is a ligand-activated transcription factor and a member of the nuclear receptor (NR) superfamily. As a receptor for bile acid (BA), FXR has been shown to play a key role in the regulation of BA metabolism, lipid metabolism, and the inflammatory response. This article reviews the roles of FXR in the pathogenesis of various lung diseases, and identifies potential diagnostic indicators or therapeutic targets for these diseases.

Treatment effects of platelet-rich plasma combined with arthroscopic microfracture for knee cartilage injury.

Objective: To analyze the clinical effects of platelet-rich plasma (PRP) combined with arthroscopic microfracture (MF) in patients with knee cartilage injury.

Methods: Eighty cases of knee cartilage injury treated in Lu'an Hospital of PKU HealthCare during July 2019 and July 2021 were selected for this study. Patients were divided into a control group (CG, treated with MF alone, n=36) and an observation group (OG, treated with MG+PRP, n=44) based on their intervention regimen.

Levofloxacin combined with azithromycin shows greater efficacy in cervicitis treatment compared to azithromycin monotherapy.

Objective: To evaluate the efficacy of levofloxacin combined with azithromycin in the treatment of cervicitis and its effect on serum inflammatory markers.

Methods: A retrospective analysis was conducted on the clinical records of 102 patients with cervicitis treated at Gansu Provincial Maternity and Child-care Hospital between March 2022 and March 2023. The control group (47 patients) received azithromycin, while the study group (55 patients) was treated with a combination of levofloxacin and azithromycin.

Establishment and application of an intraoperative reperfusion arrhythmia prediction model for PCI in elderly patients with acute coronary syndrome.

Objective: To investigate the characteristics of reperfusion arrhythmia during direct percutaneous coronary intervention (PCI) in elderly patients with acute coronary syndrome (ACS) and its impact on prognosis.

Methods: A total of 286 elderly ACS patients admitted to Kweichow Moutai Hospital from January 2019 to February 2023 were included in this retrospective study, with 200 patients used for model development and 86 for validation. Patients were selected based on predefined inclusion and exclusion criteria applied to existing medical records.

Development and external validation of a nomogram to predict the prognosis of patients with metastatic prostate cancer who underwent radiotherapy.

Background: Metastatic prostate cancer (mPCa) complicates treatment due to its unpredictable progression. Current prognostic tools often lack precision. This study aimed to develop an effective tool to predict overall survival (OS) in mPCa patients undergoing radiotherapy, thereby addressing the clinical need for personalized treatment decisions.

The diagnostic value of contrast-enhanced ultrasound combined with clinicopathological features in microinvasive ductal carcinoma .

Background: Ductal carcinoma in situ with microinvasion (DCISM) represents 1% of all breast cancer cases and is arguably a more aggressive subtype of ductal carcinoma in situ (DCIS). Preoperative evaluation of DCISM usually relies on core needle biopsy, and non-invasive evaluation methods are relatively limited. This study aims to explore the features of conventional ultrasound (US) and contrast-enhanced ultrasound (CEUS) in DCISM and to analyze the US and clinicopathological predictors of infiltrating components.

Image reconstruction in graphic design based on Global residual Network optimized compressed sensing model.

The article aims to address the challenges of information degradation and distortion in graphic design, focusing on optimizing the traditional compressed sensing (CS) model. This optimization involves creating a co-reconstruction group derived from compressed observations of local image blocks. Following an initial reconstruction of compressed observations within similar groups, an initially reconstructed image block co-reconstruction group is obtained, featuring degraded reconstructed images.

Thyroid FT4-to-TSH ratio in the first trimester is associated with gestational diabetes mellitus in women carrying male fetus: a prospective bi-center cohort study.

Background: Gestational diabetes mellitus (GDM) is one of the most common medical complications of pregnancy, which increases the risk of other pregnant complications and adverse perinatal outcomes. Thyroid dysfunction is closely with the risk of diabetes mellitus. However, the relationship between euthyroid function in early pregnancy and GDM is still controversial.