Insights into the history and tendency of glycosylation and digestive system tumor: A bibliometric-based visual analysis.

Background: Glycosylation, a commonly occurring post-translational modification, is highly expressed in several tumors, specifically in those of the digestive system, and plays a role in various cellular pathophysiological mechanisms. Although the importance and detection methods of glycosylation in digestive system tumors have garnered increasing attention in recent years, bibliometric analysis of this field remains scarce. The present study aims to identify the developmental trends and research hotspots of glycosylation in digestive system tumors.

A novel nomogram for predicting cancer-specific survival in women with uterine sarcoma: a large population-based study.

Background: Uterine sarcoma (US) is a rare malignant uterine tumor with aggressive behavior and rapid progression. The purpose of this study was to constructa comprehensive nomogram to predict cancer-specific survival (CSS) of patients with US-based on the Surveillance, Epidemiology, and End Results (SEER) database.

Methods: A retrospective population-based study was conducted using data from patients with US between 2010 and 2015 from the SEER database.

[Effect of Biochar on CH and NO Emissions from Lou Soil].

In order to investigate the effect of biochar on CH and NO emissions from Lou soil, field plot experiments of winter wheat were conducted with five levels of biochar addition (0, 20, 40, 60, and 80 t·hm). The fluxes of CH and NO, wheat production, soil organic carbon, soil water content, and temperature of each soil layer were measured. The results showed that the fluxes of CH and NO changed significantly in different growth periods of winter wheat.

Colistin resistance gene mcr-1 in gut flora of children.

The aim of this study was to determine the prevalence and transmission mechanism(s) of mcr-1 in the gut flora of children. Faecal samples (n = 173) were obtained from non-diarrhoea patients at the Children's Hospital of Zhejiang University (Hangzhou, China). PCR-based analysis indicated that 17 isolates from 9.

[Influence of Biochar on Greenhouse Gases Emissions and Physico-chemical Properties of Loess Soil].

Biochar is known to be a good soil amendment to improve soil physical and biochemical characteristics, to increase crop yield, and to mitigate greenhouse gas emissions from soils. In this study, five addition levels of apple tree branches-derived biochar (0, 20, 40, 60, 80 t·hm) were used in field plot test. The effects of biochar on soil temperature, soil aggregates, NO-N, NH-N, microbial biomass carbon and greenhouse gas fluxes were investigated during the whole pepper growth season.

Statistical study to identify the key factors governing ground water recharge in the watersheds of the arid Central Asia.

Understanding the source and recharge of ground waters is of great significance to our knowledge in hydrological cycles in arid environments over the world. Northern Xinjiang in northwestern China is a significant repository of information relating to the hydrological evolution and climatic changes in central Asia. In this study, two multivariate statistical techniques, hierarchical cluster analysis (HCA) and principal component analysis (PCA), were used to assess the ground water recharge and its governing factors, with the principal idea of exploring the above techniques to utilize all available hydrogeochemical variables in the quality assessment, which are not considered in the conventional techniques like Stiff and Piper diagrams.

Enhanced Antiproliferative Effect of Carboplatin in Cervical Cancer Cells Utilizing Folate-Grafted Polymeric Nanoparticles.

Carboplatin (CRB) possesses superior anticancer effect in cervical cancer cells with lower incidence of side effects compared to that of cisplatin. However, CRB suffers from severe side effects due to undesirable tissue distributions which contribute to the low therapeutic efficacy. Here, we report a unique folic acid-conjugated chitosan-coated poly(D-L-lactideco-glycolide) (PLGA) nanoparticles (FPCC) prepared for the selective delivery of carboplatin to the cervical cancer cells.

[Effect of Sox2 on proliferation of cervical squamous cancer cell line SiHa].

Objective: To investigate the effect and its mechanism of stem cell related transcription factor Sox2 on the proliferation of cervical squamous carcinoma cell line SiHa.

Methods: Plasmid pIRES-EGFP-Sox2 or empty plasmid (pIRES-EGFP-empty) was stably transfected into SiHa cells. The expression of Sox2 was detected by both RT-PCT and Western blot.

[Establishment of mouse lens epithelial cell lines with the genotype of Hsf4-/-].

Objective: To establish mouse lens epithelial cell lines with the genotype of Hsf4-/-.

Methods: The expended mouse lens epithelial cells, which were generated from P6 Hsf4-deficient mouse lens epithelia, were immortalized with SV40-T-antigen and named MLEC/Hsf4-/- cell. The expression of alpha A-crystallin was immunoblotted.

[Differential expression of miR-21, miR-126, miR-143, miR-373 in normal cervical tissue, cervical cancer tissue and Hela cell].

Objective: To investigate the differential expression of miR-21, miR-126, miR-143 and miR-373 in normal cervical tissue, cervical cancer tissue and Hela cell.

Methods: The expressions of miR-21, miR-126, miR-143 and miR-373 were detected by real-time PCR in cervical cancer tissue, cervical tissue of benign uterine tumor and Hela cell.

Results: High expression of miR-21 was observed in cervical cancer and Hela cell, while low expression was observed in normal cervical tissue.

In vitro-activated tumor-bearing host T cells and the effectiveness of tumor vaccine immunotherapy.

Background And Objective: Vaccination during periods of lymphopenia may facilitate immune responses to weak self-antigens and enhance antitumor immunity. The objective of this study was to determine the effectiveness of tumor vaccine immunotherapy combined with immune reconstruction using tumor-bearing host immune cells in lymphopenia, and to investigate the role of tumor-bearing host T cells activated in vitro during immunotherapy.

Design And Setting: Animal study conducted in the First Affiliated Hospital of Xi'an Jiaotong University from January 2009 to January 2010.

[Evaluation of immune reconstitution with in vitro-activated T cells from a tumor-bearing host].

Aim: To evaluate the reconstituted immune system with in vitro-activated T cells from tumor-bearing rats coupled with ovarian cancer vaccination.

Methods: Fischer 344 female rats were injected with cyclophosphamide (CY) as a lymphopenia (LP) model. The immune systems of the rats were reconstituted with in vitro-activated T cells from the same individuals.

[Animal experiments of immunotherapy with ovarian tumor vaccine during lymphopenia induced by chemotherapy.].

Objective: To explore the mechanisms and effects of adoptive immunotherapy with ovarian cancer vaccine modified by GM-CSF gene which was used after immunologic reconstitution during lymphopenia induced by chemotherapy.

Methods: Lymphopenia was induced by chemotherapy with cyclophosphamide. The immune reconstituted model was built in rats.

[Effects of antiarrhythmic drug use on atrial fibrillation recurrence in atrial fibrillation patients post circumferential pulmonary vein ablation].

Objective: This prospective and randomize-controlled trial was designed to investigate the effects of antiarrhythmic drug use (AADs) on atrial fibrillation (AF) recurrence in atrial fibrillation patients post circumferential pulmonary vein ablation (CAPV).

Methods: Seventy-four consecutive AF patients underwent CAPV (41 paroxysmal and 33 drug refractory AF) were randomly assigned to receive placebo (Group A) or AADs (Group B) for 3 months. Monthly standard electrocardiograms (ECG) and Holter monitoring were performed to assess AF recurrences during 17 - 28 months follow-up.