Publications by authors named "Yue-Lan Liu"
Background: Acute fatty liver of pregnancy (AFLP) is an uncommon but potentially life-threatening complication. Lacking of prognostic factors and models renders prediction of outcomes difficult. This study aims to explore factors and develop a prognostic model to predict three-month mortality of AFLP.
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- Preeclampsia (PE) is a major cause of maternal and fetal death globally, and the study identifies the long non-coding RNA HOTAIR as a significant factor involved in PE.
- Researchers utilized various assays to show that HOTAIR is up-regulated in PE tissues and negatively affects trophoblast cell functions like proliferation, migration, and invasion by repressing the expression of miR-106a.
- The findings suggest that HOTAIR interacts with the epigenetic repressor EZH2 to inhibit miR-106a, highlighting the potential of targeting these molecules for future PE treatments.