Dysfunction of CD27IgD B cells correlates with aggravated systemic lupus erythematosus.

Objective: The apoptotic signaling pathway is obviously disordered in systemic lupus erythematosus (SLE). Natural IgM (nIgM) is important in clearing apoptotic cells and preventing them from triggering deleterious autoimmunity. B-1 and innate-like B (ILBs) cells are the main nIgM producers.

Duplication of 19q (13.2-13.31) associated with comitant esotropia: A case report.

Background: Comitant esotropia is the most common form of strabismus. It is caused by heterogeneous environmental and genetic risk factors. The pure duplication of the long arm of chromosome 19 is a rare abnormality.

[Protective effects of melatonin on cultural human retinal pigment epithelial cells against oxidative damage in vitro].

Objective: To investigate the protective effects of melatonin on the retinal pigment epithelium (RPE) against oxidative damage induced by hydrogen dioxide (H2O2) and its mechanism.

Methods: The RPE cells were seeded and divided into normal control group, oxidative damage group and the treatment group (treated with melatonin at the concentration of 1 x 10(-7) mol/L, 1 x 10(-6) mol/L, 1 x 10(-5) mol/L and 1 x 10(-4) mol/L). The model of oxidative damage on the RPE cells was established by culturing the RPE cells with H2O2 at the concentration of 600 micromol/L for 1 hour in vitro.