Malignant syphilis in a young woman: A case report.

Malignant syphilis (MS) is a rare dermatological manifestation of secondary syphilis. This case report describes a young woman that presented with a 15-day history of generalized condyloma lata and seborrheic dermatitis-like lesions at various stages. Laboratory tests showed a toluidine red unheated serum test titre of 1:128 and particle agglutination positivity.

Kleinhospitines A-D, new cycloartane triterpenoid alkaloids from Kleinhovia hospita.

Kleinhospitines A-D, four unprecedented cycloartane triterpenoid alkaloids possessing a spiro α,β-unsaturated γ-lactamlactone side chain, were isolated as two mixtures of C-23 epimers from Kleinhovia hospita. Kleinhospitines C and D represent the first examples of naturally occurring cycloartane triterpenoids with a 9α,10α-cyclopropyl ring. The structures and absolute configurations were determined on the basis of spectroscopic analyses and comprehensive quantum chemical calculations.

Capparis spinosa protects against oxidative stress in systemic sclerosis dermal fibroblasts.

High reactive oxygen species (ROS), Ha-Ras, and active ERK1/2 in fibroblasts play an essential role in the pathogenesis of systemic sclerosis (SSc). The present study was carried out to evaluate the effects of the ethanol extract from fruits of Capparis Spinosa L. (ECS) on oxidative stress and ROS-ERK1/2-Ha-Ras signal loop in SSc dermal fibroblasts in vitro.

[Effect of Capparis spinosa on fibroblast proliferation and type I collagen production in progressive systemic sclerosis].

Objective: To investigate the effects of ethanolic extract from Capparis spinosa (ECS) on the fibroblast proliferation and type I collagen production in normal and progressive systemic sclerosis (PSS).

Method: Cellular activity was determined by the MTT method. Apoptosis was detected by flow cytometry analysis of Annexin V-stained cells.

Clinical study of plasma thrombomodulin detection.

The purpose of this study was to investigate the clinical value of plasma thrombomodulin (PTM) in different diseases or in different severity or complications of diseases, PTM in 979 patients and 60 healthy controls was determined by ELISA method. The results showed that the PTM level in the control group was 20.40 +/- 7.

[Hair follicle regeneration after implantation of hair follicle cells into subcutis of nude mice].

Objective: To observe the hair follicle regeneration after implantation of hair follicle cells into the subcutis of nude mice.

Methods: The cultured hair papilla cells,dermal sheath cells and fibroblast of human scalp were mixed with the cells of hair follicle epithelium in different ratio, and then implanted into the subcutis of nude mice. The regeneration of hair follicle was observed.