Publications by authors named "Yue-Jia Song"
Article Synopsis
- Diabetic intracerebral hemorrhage (ICH) is a severe complication of diabetes, and this study explores how bone marrow mesenchymal stem cell-derived exosomes (BMSC-exo) affect neuroinflammation in diabetic patients post-ICH.
- The research involves isolating and modifying BMSC-exo with microRNA-129-5p (miR-129-5p) and injecting them into diabetic mice with ICH to analyze their effects on inflammation and nerve function.
- Results indicate that BMSC-exo enhance recovery from neuroinflammation, with miR-129-5p playing a key protective role by reducing inflammation and improving neurological outcomes in cases of concurrent diabetes and ICH.
[Expression and function of vascular endothelial growth factor and angiopoietins in rat brain after cerebral ischemia].
Zhonghua Bing Li Xue Za Zhi
December 2011
Objective: To examine the temporal and spatial expression of vascular endothelial growth factor (VEGF) and angiopoietins (Ang) in rat brain after cerebral ischemia, and to elucidate the roles they played in angiogenesis and vascular permeability.
Methods: Rats were subjected to either middle cerebral artery occlusion (MCAO) or sham operation. Reverse transcriptase-polymerase chain reaction, Western blotting, and immunohistochemistry were used to detect the expression of VEGF, Ang-1 and Ang-2 at different time points after ischemia.
Background: Recent studies have shown that androgen displays an inhibitory effect on breast cancer cell lines that express androgen receptor (AR) but not estrogen receptor (ER) and progesterone receptor (PR). We have previously reported that approximately 1/3 of ER negative high grade invasive ductal carcinomas express AR. Thus, AR can serve as a potential therapeutic target for this group of patients.
View Article and Find Full Text PDFBackground: Hyalinizing trabecular tumor (HTT) is a rare thyroid neoplasm, which shares some histologic features with thyroid papillary carcinoma (TPC). Clinically, it is frequently misdiagnosed as papillary carcinoma, even for some experienced pathologists. The aim of this study was to investigate whether HTT is variant of TPC or HTT is an independent entity of thyroid neoplasm.
View Article and Find Full Text PDFBackground: Intracerebral hemorrhage (ICH) can cause brain damage through a number of pathways. The purpose of the study was to explore the effect of thrombin, protease nexin-1 (PN-1) and protease activated receptor-1 (PAR-1) in rat and human cerebellum after ICH.
Methods: A model of ICH was produced in adult Sprague-Dawley rats by direct injection of autologous blood (50 microl) into caudate nucleus.