Publications by authors named "Yue-Hui Wu"
Article Synopsis
- The study highlights the importance of overcoming chemotherapy resistance to temozolomide (TMZ) in glioblastoma multiforme (GBM) treatment, revealing the long non-coding RNA JPX as a significant factor.
- JPX is found to be upregulated in GBM tissues and is associated with poor patient prognosis, driving cancer cell proliferation, resistance to TMZ, and enhanced DNA repair mechanisms.
- The mechanism involves JPX stabilizing and increasing the expression of PDK1 mRNA, interacting with the m6A demethylase FTO, revealing JPX's potential as a new therapeutic target for improving GBM treatment outcomes.
Evaluation of TAZ expression and its effect on tumor invasion and metastasis in human glioma.
Asian Pac J Trop Med
October 2014
Objectives: To evaluate the expression of TAZ and its role in tumor invasion and metastasis in human glioma.
Methods: The expression of TAZ protein was measured in 48 samples of surgically resected human glioma and 13 samples of normal brain tissues using immunohistochemistry. TAZ was knocked down by a retrovirus-mediated TAZ shRNA in a glioma cell line, SNB19.