Meroterpenoids from and their anti-inflammatory activities.

Three meroterpenoids, including one new compound, ranhuadujuanine E (), one new natural product, methyl ()-3-(3,7-dimethylocta-2,6-dien-1-yl)-2,4-dihydroxy-6-methylbenzoate (), and one known compound, ranhuadujuanine D (), along with two known sesquiterpenoids (-) were isolated from . Their structures were elucidated on the basis of extensive spectroscopic analysis, and the absolute configuration of C-6' in compound was assigned by using Snatzke's method. Compounds - had inhibitory effects on LPS-induced NO release in RAW264.

A review of the fernane-type triterpenoids as anti-fungal drugs.

Human fungal pathogens could cause a broad plethora of infections in both the immunocompetent and immunocompromised host. Fungal infections have become important causes of morbidity and mortality in recent years, the current arsenal of anti-fungal therapies was restricted. Ibrexafungerp was a novel, highly bioavailable glucan synthase inhibitor formulated for both intravenous and oral administration being developed by Scynexis; it was also the first novel anti-fungal drug class approved in more than 20 years.

Honokiol and magnolol: A review of structure-activity relationships of their derivatives.

Honokiol (HK) and magnolol (MAG) are typical representatives of neolignans possessing a wide range of biological activities and are employed as traditional medicines in Asia. In the past few decades, HK and MAG have been proven to be promising chemical scaffolds for the development of novel neolignan drugs. This review focuses on recent advances in the medicinal chemistry of HK and MAG derivatives, especially their structure-activity relationships.

Recent advances on cyclodepsipeptides: biologically active compounds for drug research.

Cyclodepsipeptides are a large family of peptide-related natural products consisting of hydroxy and amino acids linked by amide and ester bonds. A number of cyclodepsipeptides have been isolated and characterized from fungi and bacteria. Most of them showed antitumor, antifungal, antiviral, antimalarial, and antitrypanosomal properties.

A rare tetrahydroimidazopyridine from the marine-derived fungus sp. YK-03.

A new tetrahydroimidazopyridine named butyl (5,6,7,8)-5,6,7,8-tetrahydro-6,7,8-trihydroxy-5-(hydroxymethyl)imidazo[1,2-]pyridine-2-carboxylate(), together with eight known compounds (-), were isolated from the fermentation broth of a marine-derived fungus sp. YK-03. Their chemical structures were elucidated by extensive analysis of one-dimensional and two-dimensional NMR spectroscopy, HR-ESIMS and optical rotation.

Lignan glycosides from Fritillaria verticillata Willd. and their anti-inflammatory activities.

Three undescribed lignan glycosides, echiunines E-G (1-3), as well as eight known compounds (4-11) were isolated from Fritillaria verticillata Willd. Among them, compounds 1-3 were a series of lignan glycosides reported for the first time from genus Fritillaria. Their structures were elucidated by analyses of extensive spectroscopic data and comparison of the NMR data with those reported previously, the absolute configuration of compounds were further confirmed by calculated ECD method.

Santalane-type sesquiterpenoids and isobenzofuranones from cultures of Paraconiothyrium sporulosum YK-03.

Three undescribed santalane-type sesquiterpenoids (parasantalenoic acids A-C) and two undescribed epimeric isobenzofuranones (paraphthalides A and B) were isolated from cultures of the marine mud-associated fungus Paraconiothyrium sporulosum YK-03. Their structures were elucidated by analysis of the extensive spectroscopic and crystal X-ray diffraction data, combined with ECD calculations and comparison. Santalane-type sesquiterpenoids have been firstly found in the Paraconiothyrium species.

Cytotoxic Cyclodepsipeptides and Cyclopentane Derivatives from a Plant-Associated Fungus sp.

In this work, four new cyclodepsipeptides, fusarihexins C-E (-) and enniatin Q (), four new cyclopentane derivatives, fusarilins A-D (-), together with eight known compounds (-), were isolated from cultures of the endophytic fungus sp. The structures of the isolated compounds were elucidated by analysis of HRMS and NMR spectroscopic data. The absolute configurations were determined using Marfey's method, a modified Mosher's method, single-crystal X-ray diffraction analysis, and ECD analysis.

Twelve New Seco-Pregnane Glycosides from .

For our interest in the potential biologically active and structurally unique steroidal glycosides, continued phytochemical investigation of was carried out; twelve new seco-pregnane glycosides, cynataihosides I-L (-), M-T (-), and two known glycosides, glaucoside A () and atratcynoside F (), were isolated from the 95% ethanol extract of . Two new aglycones were found among compounds , , , and . The structures of the glycosides were elucidated based on 1D and 2D NMR spectroscopic data, HR-ESI-MS analysis, and chemical evidence.

Recent advances in medicinal chemistry of oleanolic acid derivatives.

Oleanolic acid (OA), a ubiquitous pentacyclic oleanane-type triterpene isolated from edible and medicinal plants, exhibits a wide spectrum of pharmacological activities and tremendous therapeutic potential. However, the undesirable pharmacokinetic properties limit its application and development. Numerous researches on structural modifications of OA have been carried out to overcome this limitation and improve its pharmacokinetic and therapeutic properties.

Structure Elucidation and Anti-Tumor Activities of Trichothecenes from Endophytic Fungus .

The secondary metabolites of , an endophytic fungus with anti-tumor activity isolated from Tsiang, were investigated. Five trichothecenes, including one previously undescribed metabolite, were isolated and identified. Their structures were elucidated by means of extensive spectroscopic methods; the absolute configuration of compound was determined by the ECD method.

A novel strategy by integrating chemical profiling, molecular networking, chemical isolation, and activity evaluation to target isolation of potential anti-ACE2 candidates in Forsythiae Fructus.

Background: Traditional Chinese medicine (TCM) is regarded as a large database containing hundreds to thousands of chemical constituents that can be further developed as clinical drugs, such as artemisinin in Artemisia annua. However, effectively exploring novel candidates is still a challenge faced by researchers.

Purpose: In this work, an integrated strategy combining chemical profiling, molecular networking, chemical isolation, and activity evaluation (CMCA strategy) was proposed and applied to systematically characterize and screen novel candidates, and Forsythiae fructus (FF) was used as an example.

Dissection of the Functional Mechanism of Human Gut Bacterial Strain AD16 by Secondary Metabolites' Identification, Network Pharmacology, and Experimental Validation.

Gut microbiota plays important roles in several metabolic processes, such as appetite and food intake and absorption of nutrients from the gut. It is also of great importance in the maintenance of the health of the host. However, much remains unknown about the functional mechanisms of human gut microbiota itself.

Polyhydroxylated bergamotane-type sesquiterpenoids from cultures of Paraconiothyrium sporulosum YK-03 and their absolute configurations.

Eight undescribed polyhydroxylated bergamotane-type sesquiterpenoids with bicyclic, tricyclic and tetracyclic systems, namely sporulamides A-D, sporulosoic acids A-B and sporuloketals A-B, along with three known analogs were isolated from cultures of the marine mud-associated fungus Paraconiothyrium sporulosum YK-03. The chemical structures of these sesquiterpenoids were elucidated by the extensive spectroscopic techniques of NMR and HR-ESI-MS. Assisted by the X-ray crystallography analysis and electronic circular dichroism (ECD) spectroscopic calculation and comparison, their absolute configurations were established.

Novel glutamic acid derivatives from the bulbs of Fritillaria verticillate Willd and their antitumor activities.

Four previously undescribed glutamic acid derivatives, verticillamines A-D (1-4), together with six known compounds (5-10) were isolated from the bulbs of Fritillaria verticillate Willd. The structures of (1-10) were established on the basis of UV, IR, MS, 1D and 2D NMR, and the absolute configurations of compounds (1-4) were determined by calculated ECD methods. Among them, compounds (1-3) were rare 2-methyl-γ-lactam alkaloid derivatives.

Xanthones and anthraquinones from the soil fungus sp. DWS10-P-6.

Two new xanthones, oxisterigmatocystins J and K (1-2), and two new anthraquinones, versicolorins D and E (3-4), were isolated from solid cultures of the fungus sp. DWS10-P-6, together with twelve known compounds (5-16). Their structures, including their absolute configurations, were characterized on the basis of extensive 1D NMR, 2D NMR, MS and CD spectral data.

Two new furofuran lignan glycoside derivatives from the fruit of .

Phytochemical investigation of 95% ethanol extract of the fruit of resulted in the isolation of two new furofuran lignan glycoside derivatives pinoresinoside A () and phillyrigeninside A (), along with three known ones. Their structures were established based on extensive spectroscopic data analyses and comparison with literature data. Absolute configuration of was determined by CD method.

Two new pregnane steroidal glycosides from .

As our ongoing chemical investigation, two new pregnane steroidal glycosides, cynataihosides G (), with a new aglycone, and H () were isolated from the 95% ethanol extract of . Their structures were elucidated on the basis of 1 D and 2 D NMR spectral data, HR-ESI-MS analysis and qualitative chemical methods. The compounds were subjected to detect the cytotoxicity against three human tumor cell lines (HL-60, THP-1 and PC-3).

Seven new Drimane-Type Sesquiterpenoids from a Marine-Derived Fungus YK-03.

Seven new drimane-type sesquiterpenoids, namely the sporulositols - (-), 6-hydroxydiaporol (), -sporulositol () and sporuloside () were isolated from the ethyl acetate extract of fermentation broth for a marine-derived fungus YK-03. Their structures were elucidated by analysis of extensive spectroscopic data, and the absolute configurations were established by crystal X-ray diffraction analysis and comparisons of circular dichroism data. Among them, sporulositols - (-) and -sporulositol () represent the first five examples of a unique class of drimanic mannitol derivatives, while compounds and may represent two new series of natural drimanes, possessing an aromatic ring with a rare 4,5-secodrimanic skeleton and an unusual CH-15 rearranged drimanic α-D-glucopyranside, respectively.

(±) Benzomalvins E isolated from sp. SYPF 8411 in the rhizosphere soil of .

(+) Benzomalvins E () and (-) Benzomalvins E (), a pair of epimeric derivatives, together with three known benzomalvins (), were isolated from solid cultures of a interrhizospheric fungus sp. SYPF 8411. The planar structure of (+) Benzomalvins E () has been previously reported.

Seven new cytotoxic phenylspirodrimane derivatives from the endophytic fungus .

Seven undescribed phenylspirodrimane derivatives, stachybochartins A-G (1-7), and four known analogues (8-11) were isolated from the endophytic fungus obtained from . Stachybochartins A-D are four rare C-C-coupled dimeric derivatives and stachybochartin G features a seco-bisabosqual skeleton. Their structures and configurations were elucidated spectroscopic analysis, electronic circular dichroism (ECD) calculations, the ECD exciton chirality method and the modified Mosher's method.

Iridoid, phenylethanoid and flavonoid glycosides from .

As part of our continuing efforts to explore bioactive compounds from natural resources, a new iridoid glycoside, adoxosidic acid-6'-oleuroperic ester (), together with one known phenylethanoid glycoside () and two known flavonoid glycosides () were isolated from the fruit of . The structure of the new compound () was elucidated through 1D and 2D NMR spectroscopic data and HR-ESIMS. Interestingly, compound was a monoterpene ester of one iridoid glycoside.

Seven new guanacastane-type diterpenoids from the fungus Verticillium dahliae.

Seven new guanacastane-type diterpenoids, namely dahlianes E-K (1-7), and three known ones (8-10) were isolated from the cultures of the fungus Verticillium dahliae. Their structures were established by extensive spectroscopic data analysis along with Rh(OCOCF)- and Mo(OAc)-induced electronic circular dichroism (ECD) experiment. Dahliane G showed an 80-fold potentiation effect on the sensitization of doxorubicin at the concentration of 15 μM when screening the reversal activity on doxorubicin-resistant human breast cancer cells (MCF-7/DOX).

Diphenyl Ethers from a Marine-Derived .

Six new diphenyl ethers (⁻) along with eleven known analogs were isolated from the ethyl acetate extract of a marine-derived guided by LC-UV-MS. Their structures were unambiguously characterized by HRESIMS, NMR, as well as chemical derivatization. Compounds and are rare diphenyl ether glycosides containing d-ribose.