Publications by authors named "Yue-Fen Lou"
[Sorting Nexin 16:Structure,Function,and Role in Diseases].
Zhongguo Yi Xue Ke Xue Yuan Xue Bao
December 2022
Sorting nexin 16(SNX16),a member of the SNX family,contains a phoxhomology domain that is prone to bind with phosphatidylinositol-3-phosphate domain and a C-terminal coiled-coil domain. SNX16 participates in diverse cellular processes such as endocytosis,protein sorting,and signal transduction. The dysfunctions of SNX16 are demonstrated to be involved in the occurrence of several diseases.
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- * The researchers used PCR-based microarrays and found that increasing TUT1 levels inhibits cell growth in osteosarcoma cell lines, while decreasing TUT1 promotes cell growth.
- * TUT1 possibly functions as a tumor suppressor by regulating lipogenesis-related genes through specific microRNAs, indicating its potential role in cancer development.
Many studies have reported the association between the FASLG -844T/C polymorphism and cancer risk, but the data are remaining controversial. A pooled analysis was performed to assess this relationship comprehensively. Medline, PubMed, Embase and Web of Science were searched, and data were extracted and cross-checked independently by three authors.
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