Multi-target anti-MRSA mechanism and antibiotic synergistic effect of marine alkaloid Ascomylactam A in vitro and in vivo against clinical MRSA strains.

Methicillin-resistant Staphylococcus aureus (MRSA), as a kind of multi-drug resistant bacteria, often causes serious sanitary infection problems. Marine fungi are seen as a promising source of lead compounds for antibiotics. In this research, the antibacterial activity, antibiotic synergistic effect and mechanism of the alkaloid Ascomylactam A (AsA) derived from the marine fungus Microascus sp.