New alkaloids with neuroprotective activities from Thunb.

One new lycopodine-type alkaloid (), one new natural product (), and eight known analogs () were isolated from the whole plants of Thunb. The structures of were determined based on extensive comprehensive spectroscopic analyses, including UV, IR, NMR, and HRESIMS. Moreover, the isolated alkaloids were evaluated for their neuroprotective activity against Hemin-induced HT22 cell damage.