Shifting Paradigms in Glaucoma Management: A Retrospective Analysis from 2013 to 2023.

Purpose: This study analyzes trends in glaucoma surgical management at the Eye & ENT Hospital of Fudan University over a 10-year period (2013-2023), focusing on the evolution of surgical practices and the adoption of new techniques.

Methods: A retrospective observational study was conducted using medical records of patients diagnosed with glaucoma who underwent surgery between January 1, 2013, and December 31, 2023. Data were analyzed using the Cochrane-Armitage trend test.

A weakly acidic and reductive deep eutectic solvent used for one-step efficient separation of Li and Co from spent lithium-ion batteries.

A cleaner recycling process for lithium-ion batteries can effectively relieve the pressure on metal resources to protect the environment. In this work, a weakly acidic and reductive deep eutectic solvent (lactic acid:glycolic acid = 1:1) achieves one-step separation of Li and Co from waste lithium-ion batteries. Mechanism of hydrogen bond formation in DESs by interaction region indicators, molecular dynamics simulations, FT-IR and H NMR.

Linkage Engineering of Semiconductive Covalent-Organic Frameworks toward Room-Temperature Ppb-Level Selective Ammonia Sensing.

Rational design of molecular architectures is crucial for developing advanced materials such as covalent-organic frameworks (COFs) with excellent sensing performance. In this work, two isostructural COFs (β-keto-AnCOF and imine-AnCOF) with the same conjugated linkers but distinct linkages are constructed. Although both COFs have porous structure and semiconductor behavior conferred by the identical conjugated backbones, β-keto-AnCOF with ─C═O side groups exhibits superior room-temperature ammonia (NH) sensing performance than imine-AnCOF and even the state-of-the-art dynamic and commercial NH sensors, i.

Recent advances in zeolitic imidazolate frameworks as drug delivery systems for cancer therapy.

Biological nanotechnologies based on functional nanoplatforms have synergistically catalyzed the emergence of cancer therapies. As a subtype of metal-organic frameworks (MOFs), zeolitic imidazolate frameworks (ZIFs) have exploded in popularity in the field of biomaterials as excellent protective materials with the advantages of conformational flexibility, thermal and chemical stability, and functional controllability. With these superior properties, the applications of ZIF-based materials in combination with various therapies for cancer treatment have grown rapidly in recent years, showing remarkable achievements and great potential.

Flavour enhancement of dry fermented sausages by nitrite-degrading Levilactobacillus brevis CHOL1: Combining flavouromics and lipidomics to elucidate the mechanism of aroma formation.

Levilactobacillus brevis CHOL1, exhibiting a nitrite degradation rate of 99.03 %, was added to dry fermented sausages to evaluate its effects on product quality, sensory and aroma properties. Lipidomics analysis was performed to explore the mechanism of aroma formation after inoculation.

Fasting-mimicking diet-enriched suppresses colorectal cancer by inducing memory CD8 T cells.

Background: Fasting-mimicking diet (FMD) boosts the antitumour immune response in patients with colorectal cancer (CRC). The gut microbiota is a key host immunity regulator, affecting physiological homeostasis and disease pathogenesis.

Objective: We aimed to investigate how FMD protects against CRC via gut microbiota modulation.

eIF4A1 exacerbates myocardial ischemia-reperfusion injury in mice by promoting nuclear translocation of transgelin/p53.

Eukaryotic translation initiation factor 4A1 (eIF4A1) is an ATP-dependent RNA helicase that participates in a variety of biological and pathological processes such as cell proliferation and apoptosis, and cancer. In this study we investigated the role of eIF4A1 in ischemic heart disease. The myocardial ischemia/reperfusion (I/R) model was established in mice by ligation of the left anterior descending artery for 45 min with the subsequent reperfusion for 24 h; cultured neonatal mouse ventricular cardiomyocytes (NMVCs) treated with HO (200 μM) or H/R (12 h hypoxia and 12 h reoxygenation) were used for in vitro study.

Exploring the synergistic effect of Lactiplantibacillus plantarum 1-24-LJ and lipase on improving Quality, Flavor, and safety of Suanzharou.

The aim of this study was to investigate the effects of the addition of Lactiplantibacillus plantarum 1-24-LJ and lipase on physicochemical indexes, nutrition, and flavour substances during Suanzharou's fermentation. Individually, the lipase supplementation expedited the synthesis of organic acids and free fatty acids, thus rapidly acidifying the fermentation environment. Compared to C (8.

Tumor metastasis and recurrence: The role of perioperative NETosis.

Although surgical resection of tumor mass remains the mainstay of curative therapeutic management for solid tumors, accumulating studies suggest that these procedures promote tumor recurrence and metastasis. Regarded as the first immune cells to fight against infectious or inflammatory insults from surgery, neutrophils along with their ability of neutrophil extracellular traps (NETs) production has attracted much attention. A growing body of evidence suggests that NETs promote cancer metastasis by stimulating various stages, including local invasion, colonization, and growth.

Parallelization of particle-based reaction-diffusion simulations using MPI.

Particle-based reaction-diffusion models offer a high-resolution alternative to the continuum reaction-diffusion approach, capturing the discrete and volume-excluding nature of molecules undergoing stochastic dynamics. These methods are thus uniquely capable of simulating explicit self-assembly of particles into higher-order structures like filaments, spherical cages, or heterogeneous macromolecular complexes, which are ubiquitous across living systems and in materials design. The disadvantage of these high-resolution methods is their increased computational cost.

Nature of Disordering in γ-Ga_{2}O_{3}.

Polymorphs commonly exist for various materials, enabling phase engineering for diverse material properties. While the crystal structures of different polymorphs can, in principle, be experimentally characterized, interpreting and understanding complex crystal structures can be very challenging. Using Ga_{2}O_{3} as a prototype, here we show that the crystal structure of γ-Ga_{2}O_{3} has long been misinterpreted from either theory or experiment.

Identification of new antigenic epitopes of porcine reproductive and respiratory syndrome virus nsp12 protein using monoclonal antibodies.

Porcine reproductive and respiratory syndrome virus (PRRSV), a member of the arteritis virus family, significantly impacts the swine industry due to its high infectiousness. nsp12, the nonstructural protein encoded by PRRSV, is a membrane-associated protein, with limited knowledge about its antigenic properties and functions. In this study, we used the expressed and purified nsp12 protein as antigen to immunize mice, and successfully screened five positive hybridoma cell lines that stably secrete anti-nsp12 monoclonal antibodies using immunological assays such as indirect ELISA and IFA.

Pegylated liposomal doxorubicin in partially platinum-sensitive, platinum-resistant, or platinum-refractory ovarian cancer: a prospective study.

Background: This study aimed to evaluate the efficacy and safety of pegylated liposomal doxorubicin (PLD) for patients with partially platinum-sensitive, platinum-resistant, or platinum-refractory ovarian cancer.

Methods: Patients with partially platinum-sensitive, platinum-resistant, or platinum-refractory ovarian cancer were recruited in this prospective, open-label, single-arm, multicenter study. Eligible patients were given 4-6 cycles of PLD (40 mg/m2 on day 1, every 4 weeks).

Novel antibacterial pullulan derivatives modified with quaternary phosphonium salts for infected wound treatments.

The development of novel antibacterial agents is urgently needed to tackle bacterial infection, the major global issue menacing human health. Among them, polymeric quaternary phosphonium salts are worth noticing owing to their strong antibacterial activities and other merits including low bacterial drug resistance. Herein, pullulan modified with quaternary phosphonium salts (PQP) was synthesized using esterification reactions of pullulan and (5-carboxypentyl)triphenylphosphonium bromide (CPTPPB) mediated by N,N'‑carbonyldiimidazole (CDI), and was evaluated as novel antibacterial agents for treating wound infection for the first time.

Classification of distinct tendinopathy subtypes for precision therapeutics.

Rotator cuff tendinopathy is the most common tendinopathy type with the worst prognosis. Conventional treatments often elicit heterogeneous drug responses due to the diversity of tendinopathy. Hence, this study attempted a classification of 126 diseased tendons into three distinct subtypes with opposite pathogenic mechanisms based on transcriptomic and clinical features.

Acetylcysteine synergizes PD-1 blockers against colorectal cancer progression by promoting TCF1PD1CD8 T cell differentiation.

Background: Programmed cell death protein 1 (PD-1) blockade is essential in treating progressive colorectal cancer (CRC). However, some patients with CRC do not respond well to immunotherapy, possibly due to the exhaustion of CD8 T cells in the tumor microenvironment. N-Acetylcysteine (NAC) can reduce CD8 T cell exhaustion in vitro and induce their differentiation into long-lasting phenotypes, thus enhancing the anti-tumor effect of adoptive T cell transfer.

Palmitic acid inhibits macrophage-mediated chemotherapy resistance in multiple myeloma via ALOX12 signaling.

We previously discovered that macrophages (MΦs), especially tumor-associated MΦs (tMΦs), contribute to chemotherapy resistance in multiple myeloma (MM). However, the mechanism underlying MΦ-mediated chemotherapy resistance in MM needs further elucidation, and the identification of factors that preferentially abrogate MΦ-induced inhibition of MM chemotherapy may have important clinical significance. In this study, we showed that the expression of FASN and SCD2, the enzymes that synthesize palmitic acid and convert it to palmitoleic acid, was decreased in tMΦs compared with MΦs.

Association between high-density lipoprotein-related inflammation index and periodontitis: insights from NHANES 2009-2014.

Background: Periodontitis, a persistent inflammatory condition, significantly impairs individuals' overall quality of life. Lymphocyte-to-high-density lipoprotein cholesterol ratio (LHR), monocyte-to-high-density lipoprotein cholesterol ratio (MHR), neutrophil-to-high-density lipoprotein cholesterol ratio (NHR), and platelet-to-high-density lipoprotein cholesterol ratio (PHR) are new convenient and economical biomarkers. However, whether the above high-density lipoprotein-related inflammatory biomarkers are associated with periodontitis has rarely been investigated.

Analysis of seasonal H3N2 influenza virus epidemic characteristics and whole genome features in Jining City from 2018 to 2023.

Seasonal H3N2 influenza virus, known for its rapid evolution, poses a serious threat to human health. This study focuses on analyzing the influenza virus trends in Jining City (2018-2023) and understanding the evolving nature of H3N2 strains. Data on influenza-like cases were gathered from Jining City's sentinel hospitals: Jining First People's Hospital and Rencheng Maternal and Child Health Hospital, using the Chinese Influenza Surveillance Information System.

STAT3 drives the expression of HIF1alpha in cancer cells through a novel super-enhancer.

Aerobic glycolysis is one of the major hallmarks of malignant tumors. This metabolic reprogramming benefits the rapid proliferation of cancer cells, facilitates the formation of tumor microenvironment to support their growth and survival, and impairs the efficacy of various tumor therapies. Therefore, the elucidation of the mechanisms driving aerobic glycolysis in tumors represents a pivotal breakthrough in developing therapeutic strategies for solid tumors.