Socioeconomic disparities in childhood vaccine hesitancy among parents in China: The mediating role of social support and health literacy.

Parental vaccine hesitancy is a major obstacle to childhood vaccination. We examined parental socioeconomic status (SES) disparities in vaccine hesitancy, and the potential mediating roles of perceived social support and health literacy. A questionnaire survey was given to parents with children aged below 6 years from six provinces in China.

Characterization of Odorants Causing the Hawthorn Aroma in Cabernet Sauvignon Wine by Gas Chromatography-Olfactometry, Quantitation, Aroma Recombination, Omission, and Addition Studies.

This study aimed to identify the specific odorants contributing to the distinctive hawthorn aroma present in wines, expanding upon previous research on the aroma characteristics of Cabernet Sauvignon wine. By utilization of high-performance liquid chromatography and gas chromatography-olfactory-mass spectrometry, 14 odorants showed a positive correlation with hawthorn aroma characteristics. Among these, ethyl isovalerate, ethyl butanoate, myrcene, and α-terpineol demonstrated the highest correlation coefficients.

Clustering-Based Thermography for Detecting Multiple Substances Under Large-Scale Floating Covers.

This study presents a novel approach for monitoring waste substrate digestion under high-density polyethylene (HDPE) geomembranes in sewage treatment plants. The method integrates infrared thermal imaging with a clustering algorithm to predict the distribution of various substrates beneath Traditional outdoor large-scale opaque geomembranes, using solar radiation as an excitation source. The technique leverages ambient weather conditions to assess the thermal responses of HDPE covers.

Low-Toxicity and High-Stability Fluorescence Sensor for the Selective, Rapid, and Visual Detection Tetracycline in Food Samples.

With the development and improvement of analysis and detection systems, low-toxicity and harmless detection systems have received much attention, especially in the field of food detection. In this paper, a low-toxicity dual-emission molecularly imprinted fluorescence sensor (CdTe QDs@SiO/N-CDs@MIPs) was successfully designed for highly selective recognition and visual detection of tetracycline (TC) in food samples. Specifically, the non-toxic blue-emission N-doped carbon dots (N-CDs) with high luminous performance acted as the response signals to contact TC via the covalent bond between amino and carboxyl groups.

Should all cervical cancer patients with positive lymph node receive definitive radiotherapy: a population-based comparative study.

Objective: The optimal initial management strategy for cervical cancer with lymph node metastases (LNM) remains a topic of ongoing debate. This study aimed to explore the correlation between surgery followed by postoperative radiotherapy (PORT) and definitive radiotherapy (RT), as well as their impact on the prognosis of patients with LNM.

Methods: Patients with positive lymph nodes (PLNs) in 2009 FIGO stage I-III cervical cancer were selected from SEER database.

Global, regional, and national burdens of heart failure in adolescents and young adults aged 10-24 years from 1990 to 2021: an analysis of data from the Global Burden of Disease Study 2021.

Background: Prior studies suggest prevalence of heart failure (HF) has remained steady or progressively decreased over past 30 years in the general population. Whether this favourable trend occurred in adolescents and young adults aged 10-24 years has yet to be elucidated. We aim to identify the trends in the burden of HF in this young population from 1990 to 2021 to inform areas for targeted intervention and prevention efforts.

Does the FNA sperm retrieval failure prediction model work well for current NOA individuals undertaking risk screening before the operation? Model validation, high-risk population identification and potential alternative sperm retrieval exploration.

Background: Non-obstructive azoospermia (NOA), the severe type of male infertility. The objective of this study was to evaluate the predictive accuracy of a prediction model of sperm retrieval failure with fine needle aspiration (FNA).

Methods: This study involved 769 NOA patients (dataset 1) undertaking FNA and 140 NOA patients undertaking mTESE (dataset 2).

Important ecophysiological roles of Nocardiopsis in lignocellulose degradation during aerobic compost with humic acid addition.

Improving lignocellulose degradation and organic matter conversion in agricultural and livestock wastes remains a great challenge. Here, the contribution of humic acid (HA) to lignocellulose degradation was investigated, focusing on the abundance of key microbial species and carbohydrate-active enzymes during aerobic composting. The results demonstrated that the addition of HA not only increased the complexity of the microbial network, but also enhanced the positive interaction between microorganism.

Gut microbiota-derived 4-hydroxyphenylacetic acid from resveratrol supplementation prevents obesity through SIRT1 signaling activation.

Resveratrol (RSV), a natural polyphenol, has been suggested to influence glucose and lipid metabolism. However, the underlying molecular mechanism of its action remains largely unknown due to its multiple biological targets and low bioavailability. In this study, we demonstrate that RSV supplementation ameliorates high-fat-diet (HFD)-induced gut microbiota dysbiosis, enhancing the abundance of anti-obesity bacterial strains such as and .

Abnormalities of resting-state EEG microstates in older adults with cognitive frailty.

This study aims to analyze the characteristics of EEG microstates across different cognitive frailty (CF) subtypes, providing insights for the prevention and early diagnosis of CF. This study included 60 eligible older adults. Their resting-state EEG microstates were analyzed using agglomerative adaptive hierarchical clustering.

Integrated Transcriptome and Metabolome Analysis Reveals Insights into Flavone and Flavonol Biosynthesis in Salicylic Acid-Induced Huanglongbing Tolerance.

Salicylic acid (SA) exhibits positive effects against Huanglongbing (HLB), but how SA affects citrus resistance to HLB is currently unknown. This study conducted integrated transcriptome and metabolome analyses on SA-treated (HLB-sensitive) and (HLB-tolerant). The results indicated that the syntheses of flavones and flavonols were induced by SA, while the expression levels of associated genes and the contents of corresponding metabolites varied significantly between the two species after SA treatment or HLB infection.

Enabling structural biological electron paramagnetic resonance spectroscopy in membrane proteins through spin labelling.

Pulsed dipolar electron paramagnetic resonance spectroscopy (PDS), combined with site-directed spin-labelling, represents a powerful tool for the investigation of biomacromolecules, emerging as a keystone approach in structural biology. Increasingly, PDS is applied to study highly complex integral membrane protein systems, such as mechanosensitive ion channels, transporters, G-protein coupled receptors, ion pumps, and outer membrane proteins elucidating their dynamics and revealing conformational ensembles. Indeed, PDS offers a platform to study intermediate or lowly-populated states that are otherwise invisible to other modern methods, such as X-ray crystallography, cryo-EM, and hydrogen-deuterium exchange-mass spectrometry.

[Suggestions for revision of quality standards of red yeast rice for medicinal and edible purposes in China].

Red yeast rice(RYR) is fermented rice with a long history of medicinal and edible purposes in China. RYR has gained global popularity, particularly in South and Southeast Asia, Europe, and America, due to its blood lipid-lowering effect and abundant edible natural pigments. However, concerns have been aroused regarding the safety of RYR due to increasing reports on the side effects and toxicity associated with statins and mycotoxins in RYR.

Effects of intravenous anesthesia and inhalation anesthesia on postoperative inflammatory markers in patients with esophageal cancer: a retrospective study.

Background: Inflammatory markers have been confirmed to be associated with the prognosis of cancer patients. In this study, we compared the impacts of intravenous anesthesia and inhalation anesthesia on the neutrophil-to-lymphocyte ratio (NLR), the platelet-to-lymphocyte ratio (PLR), and the systemic immune-inflammation index (SII) after esophageal cancer surgery.

Methods: We retrospectively reviewed the electronic medical records of patients who underwent esophagectomy from January 1, 2014 to December 31, 2016.

Regulating Crystalline Phase/Plane of Polymer Electrolyte for Rapid Lithium Ion Transfer.

Electronic-rich functional groups and flexible segments have long been perceived to be the decisive factors influencing lithium-ion transfer in polymer electrolytes, while crystallinity is regarded as the great scourge. Actually, the research on the influence of crystalline phase and crystalline plane is still in scarcity. Herein, taking poly(vinylidene fluoride)-hexafluoropropylene (PVDF-HFP) as an example, new (111/201) crystal planes (belonged to β-phase) are regulated by dissolving process and clarified by Synchrotron radiation X-ray diffraction and X-ray diffraction.

OperaGAN: A simultaneous transfer network for opera makeup and complex headwear.

Standard makeup transfer techniques mainly focus on facial makeup. The texture details of headwear in style examples tend to be ignored. When dealing with complex portrait style transfer, simultaneous correct headwear and facial makeup transfer often cannot be guaranteed.

Revealing extensive inbreeding and less-efficient purging of deleterious mutations in wild Amur tigers in China.

Inbreeding increases genome homozygosity within populations, which can exacerbate inbreeding depression by exposing homozygous deleterious alleles that are responsible for declines in fitness traits. In small populations, genetic purging that occurs under pressure of natural selection acts as an opposing force, contributing to a reduction of deleterious alleles. Both inbreeding and genetic purging are paramount in the field of conservation genomics.

Association Between Multimorbidity and Depression in Older Adults: Evidence From Six Large Longitudinal Cohorts.

Background: Multimorbidity may increase the risk of depression in older adults, but the global average effect of multimorbidity on depression remains unknown. This research aimed to exclude the regional heterogeneity to quantify the exposure-response association between multimorbidity and depression in older adults worldwide.

Method: We collected 23,947 participants aged 65 years or above from six large prospective cohorts from developed and developing countries, including Mexico, South Korea, Europe, America, China, and England.

Constraints to Child Language Development in Peri-Urban and Rural Areas: A Mixed-Methods Analysis From Southwestern China.

Purpose: This mixed-methods study examined how differences in parental time, knowledge, and economic constraints, as well as community socioeconomic contexts, may contribute to differences in home language environment and child language ability outcomes between peri-urban and rural households in China.

Method: We conducted an explanatory sequential mixed-methods analysis using data from 158 children aged 18-24 months among peri-urban and rural households with low socioeconomic status (SES) in southwestern China. Audio recordings were collected from each household and analyzed using the Language ENvironment Analysis system.

GOLM1 promotes cholesterol gallstone formation via ABCG5-mediated cholesterol efflux in MASH livers.

Background/aims: Metabolic dysfunction-associated steatohepatitis (MASH) is a significant risk factor for gallstone formation, but mechanisms underlying MASH-related gallstone formation remain unclear. Golgi membrane protein 1 (GOLM1) participates in hepatic cholesterol metabolism and is upregulated in MASH. Here, we aimed to explore the role of GOLM1 in MASH-related gallstone formation.

Targeting Arachidonic Acid Metabolism Enhances Immunotherapy Efficacy in ARID1A-Deficient Colorectal Cancer.

ARID1A, a core constituent of SWI/SNF complex, is mutated in approximately 10% of colorectal cancers (CRC). While ARID1A deficiency corresponds to heightened immune activity in CRC, immune checkpoint inhibitors (ICIs) have shown limited efficacy in these tumors. The discovery of targetable vulnerabilities associated with ARID1A deficiency in CRC could expand treatment options for patients.

Epitope-imprinted biomaterials with tailor-made molecular targeting for biomedical applications.

Molecular imprinting technology (MIT), a synthetic strategy to create tailor-made molecular specificity, has recently achieved significant advancements. Epitope imprinting strategy, an improved MIT by imprinting the epitopes of biomolecules (e.g.

Serum concentrations of different or multiple vitamins and Sarcopenia risk among US adults: insights from NHANES.

Background: The relationship between serum concentrations of different or multiple vitamins and sarcopenia remains underexplored. This investigation evaluates potential links between serum concentrations of different or multiple vitamins and sarcopenia prevalence among adults in the United States.

Methods: Utilizing a cross-sectional design, this research draws from the National Health and Nutrition Examination Survey (NHANES) dataset of 2003-2006, encompassing 5,060 participants with comprehensive serum vitamin A, E, B9, B12, C, and D concentrations, alongside sarcopenia and covariate measurements.