Probiotics Treatment of Leg Diseases in Broiler Chickens: a Review.

Normal development and growth of bones are critical for poultry. With the rapid growth experienced by broiler chickens, higher incidences of leg weakness and lameness are common problems in adolescent meat-type poultry that present huge economic and welfare issues. Leg disorders such as angular bone deformities and tibial dyschondroplasia have become common in broilers and are associated with poor growth, high mortality rates, increased carcass condemnation, and downgrading at slaughter.

REHE: Fast variance components estimation for linear mixed models.

Linear mixed models are widely used in ecological and biological applications, especially in genetic studies. Reliable estimation of variance components is crucial for using linear mixed models. However, standard methods, such as the restricted maximum likelihood (REML), are computationally inefficient in large samples and may be unstable with small samples.

A Transparent, Highly Stretchable, Solvent-Resistant, Recyclable Multifunctional Ionogel with Underwater Self-Healing and Adhesion for Reliable Strain Sensors.

Ionogels have gained increasing attentions as a flexible conductive material. However, it remains a big challenge to integrate multiple functions into one gel that can be widely applied in various complex scenes. Herein, a kind of multifunctional ionogels with a combination of desirable properties, including transparency, high stretchability, solvent and temperature resistance, recyclability, high conductivity, underwater self-healing ability, and underwater adhesiveness is reported.

The diagnostic value of thyroglobulin in fine-needle aspiration of metastatic lymph nodes in patients with papillary thyroid cancer and its influential factors.

Thyroglobulin (Tg) measurement in fine-needle aspiration (FNA-Tg) has proved to be an excellent tool to identify metastatic cervical lymph nodes (CLN) before or after surgery for papillary thyroid cancer (PTC). The diagnostic value of FNA-Tg for metastatic CLN in PTC patients is higher than that of ultrasound (US) and fine-needle aspiration cytology (FNAC), especially for small or cystic LN. The combination of FNAC and FNA-Tg can provide nearly 100% diagnostic sensitivity and specificity for CLN metastasis.

Genetically predicted insomnia and lung cancer risk: a Mendelian randomization study.

Background: The relationship between insomnia and lung cancer is scanty. The Mendelian randomization approach provides the rationale for evaluating the potential causality between genetically-predicted insomnia and lung cancer risk.

Methods: We extracted 148 insomnia-related single-nucleotide polymorphisms (SNPs) as instrumental variables (IVs) from published genome-wide association studies (GWASs).

Design, synthesis and biological evaluation of hybrid of ubenimex-fluorouracil for hepatocellular carcinoma therapy.

In our previous study, we discovered a ubenimex-fluorouracil (5FU) conjugates BC-02, which displays significant in vivo anti-tumor activity, however, the instability of BC-02 in plasma limits its further development as a drug candidate. Herein, we designed and synthesized four novel ubenimex-5FU conjugates by optimizing the linkers between ubenimex and 5FU based on BC-02. Representative compound 20 is more stable than BC-02 in human plasma and displays about 100 times higher CD13 inhibitory activity than the positive control ubenimex.

Aflatoxin B1 alters meat quality associated with oxidative stress, inflammation, and gut-microbiota in sheep.

Aflatoxin B1 (AFB1) is an unavoidable contaminant in animal feed and agricultural products. AFB1 has been found to impair the liver and kidney function of sheep. However, few data are available, which explain the toxic damage of AFB1 exposure on meat quality.

Differential effects of altered precipitation regimes on soil carbon cycles in arid versus humid terrestrial ecosystems.

Changes in precipitation regimes have significant effects on soil carbon (C) cycles; however, these effects may vary in arid versus humid areas. Additionally, the corresponding details of soil C cycles in response to altered precipitation regimes have not been well documented. Here, a meta-analysis was performed using 845 pairwise observations (control vs.

An Assistive Coughing Device for Post-Laryngectomy Patients.

People who have undergone total laryngectomy typically have difficulties speaking and coughing. Coughing, the protective reflex action where air is rapidly expelled from the lungs to clear the airway, is crucial in everyday life. Insufficiency in coughing can lead to serious chest infections.

Induces Proinflammatory Cytokine Production in Mouse Macrophages TLR9-Mediated p38 and ERK Signaling Pathways.

, also known as or , is an important opportunistic, pathogenic, zoonotic, protozoan parasite that infects the small intestines of humans and animals, causing giardiasis. Several studies have demonstrated that innate immunity-associated Toll-like receptors (TLRs) are critical for the elimination of ; however, whether TLR9 has a role in innate immune responses against infection remains unknown. In the present study, various methods, including reverse transcriptase-quantitative polymerase chain reaction, Western blot, enzyme-linked immunosorbent assay, immunofluorescence, inhibitor assays, and small-interfering RNA interference, were utilized to probe the role of TLR9 in mouse macrophage-mediated defenses against virus (GLV)-free or GLV-containing trophozoites.

Development and Validation of a Nomogram based on cell growth-related Biomarkers for Oral Squamous Cell Carcinoma.

We aimed to develop a prognostic nomogram based on immunohistochemistry (IHC) biomarkers of patients with oral squamous cell carcinoma (OSCC). A total of 294 patients were enrolled in the study. The least absolute shrinkage and selection operator (LASSO) Cox regression model was performed to develop a combined IHC score (IHCs) classifier.

JOSD1 promotes proliferation and chemoresistance of head and neck squamous cell carcinoma under the epigenetic regulation of BRD4.

Background: Deubiquitinating enzymes (DUBs) play critical roles in various cancers by modulating functional proteins post-translationally. Previous studies have demonstrated that DUB Josephin Domain Containing 1 (JOSD1) is implicated in tumor progression, however, the role and mechanism of JOSD1 in head and neck squamous cell carcinoma (HNSCC) remain to be explored. In this study, we aimed to identify the clinical significance and function of JOSD1 in HNSCC.

Surgical Extent of Central Lymph Node Dissection for Papillary Thyroid Carcinoma Located in the Isthmus: A Propensity Scoring Matched Study.

Introduction: To assess the risk factor for the central lymph node (CLN) metastasis and investigated the surgery extent of lymph node dissection for patients with isthmic PTC (papillary thyroid carcinoma).

Materials And Methods: A total of 669 patients with a single nodule of isthmic PTC were retrospectively reviewed. The propensity score matching was performed twice separately.

Thickness control of 2D nanosheets assembled from precise side-chain giant molecules.

The performance of 2D nanomaterials hinges on both the chemical compositions and the morphological structures across different length scales. Among all the three dimensions, thickness is the only one that falls into the nanometer scale and, to some extent, determines the intrinsic properties of 2D nanomaterials. In this study, we report the preparation and precise thickness control of 2D nanosheets assembled from a library of monodispersed amphiphilic giant molecules composed of functional polyhedral oligomeric silsesquioxanes (POSSs) as the side groups.

Recent Advances on MOF Derivatives for Non-Noble Metal Oxygen Electrocatalysts in Zinc-Air Batteries.

Oxygen electrocatalysts are of great importance for the air electrode in zinc-air batteries (ZABs). Owing to the high specific surface area, controllable pore size and unsaturated metal active sites, metal-organic frameworks (MOFs) derivatives have been widely studied as oxygen electrocatalysts in ZABs. To date, many strategies have been developed to generate efficient oxygen electrocatalysts from MOFs for improving the performance of ZABs.

Automatic Recognition and Classification System of Thyroid Nodules in CT Images Based on CNN.

Thyroid nodule lesions are one of the most common lesions of the thyroid; the incidence rate has been the highest in the past thirty years. X-ray computed tomography (CT) plays an increasingly important role in the diagnosis of thyroid diseases. Nonetheless, as a result of the artifact and high complexity of thyroid CT image, the traditional machine learning method cannot be applied to CT image processing.

netgsa: Fast computation and interactive visualization for topology-based pathway enrichment analysis.

Existing software tools for topology-based pathway enrichment analysis are either computationally inefficient, have undesirable statistical power, or require expert knowledge to leverage the methods' capabilities. To address these limitations, we have overhauled NetGSA, an existing topology-based method, to provide a computationally-efficient user-friendly tool that offers interactive visualization. Pathway enrichment analysis for thousands of genes can be performed in minutes on a personal computer without sacrificing statistical power.

Synthesis and regulation of auxin and abscisic acid in maize.

Indole-3-acetic acid (IAA), the primary auxin in higher plants, and abscisic acid (ABA) play crucial roles in the ability of maize ( L.) to acclimatize to various environments by mediating growth, development, defense and nutrient allocation. Although understanding the biochemical reactions for IAA and ABA biosynthesis and signal transduction has progressed, the mechanisms by which auxin and ABA are synthesized and transduced in maize have not been fully elucidated to date.

The Role of Chinese Herbal Therapy in Methamphetamine Abuse and its Induced Psychiatric Symptoms.

Repeated intake of methamphetamine (METH) leads to drug addiction, the inability to control intake, and strong drug cravings. It is also likely to cause psychiatric impairments, such as cognitive impairment, depression, and anxiety. Because the specific neurobiological mechanisms involved are complex and have not been fully and systematically elucidated, there is no established pharmacotherapy for METH abuse.

Characterization of YAG:Ce phosphor dosimeter by the co-precipitation method for radiotherapy.

Yttrium aluminum garnet (YAG) doped with Ce was synthesized via the co-precipitation method with as the precipitant. The spectroscopic properties and the effects of the Ce doping concentration and sintering atmosphere on the crystal phase were investigated. The dosimeter of YAG:Ce phosphor material was prepared to study the radioluminescence (RL) characteristics of a clinical linear accelerator.

A naphthalimide-polyamine conjugate preferentially accumulates in hepatic carcinoma metastases as a lysosome-targeted antimetastatic agent.

Disseminated tumors lead to approximately 90% of cancer-associated deaths especially for hepatocellular carcinoma (HCC), indicating the imperative need of antimetastatic drugs and the ineffectiveness of current therapies. Recently polyamine derivatives have been identified as a promising prospect in dealing with metastatic tumors. Herein, a novel class of naphthalimide-polyamine conjugates 8a-8d, 13a-13c, 17 and 21 were synthesized and the mechanism was further determined.

The PSMD14 inhibitor Thiolutin as a novel therapeutic approach for esophageal squamous cell carcinoma through facilitating SNAIL degradation.

Metastasis and chemoresistance are major causes of poor prognosis in patients with esophageal squamous cell carcinoma (ESCC), manipulated by multiple factors including deubiquitinating enzyme (DUB). DUB PSMD14 is reported to be a promising therapeutic target in various cancers. Here, we explored the antitumor activity of Thiolutin (THL), the PSMD14 inhibitor, as a new therapy strategy in ESCC.

A Framework for Automatic Burn Image Segmentation and Burn Depth Diagnosis Using Deep Learning.

Burn is a common traumatic disease with high morbidity and mortality. The treatment of burns requires accurate and reliable diagnosis of burn wounds and burn depth, which can save lives in some cases. However, due to the complexity of burn wounds, the early diagnosis of burns lacks accuracy and difference.

Global patterns and drivers of rainfall partitioning by trees and shrubs.

Spatiotemporal redistribution of incident rainfall in vegetated ecosystems results from the partitioning by plants into intercepted, stemflow, and throughfall fractions. However, variation in patterns and drivers of rainfall partitioning across global biomes remains poorly understood, which limited the ability of climate models to improve the predictions of biome hydrological cycle under global climate change scenario. Here, we synthesized and analyzed the partitioning of incident rainfall into interception, stemflow, and throughfall by trees and shrubs at the global scale using 2430 observations from 236 independent publications.

Diagnostic Model Incorporating Clinicopathological Characteristics of Delphian Lymph Node Metastasis Risk Profiles in Papillary Thyroid Cancer.

The Delphian lymph node (DLN), also known as the prelaryngeal node, is one component of the central lymph node. The DLN has been well studied in laryngeal cancer, although its significance in papillary thyroid cancer (PTC) remains unclear. We retrospectively analyzed 936 patients with PTC who underwent thyroidectomy by a single surgeon in Tianjin Cancer Hospital from 2017 to 2019.