Preparation of High-Performance Polyethylene Nanocomposites with Oleic Acid-Siloxene-Supported Ziegler-Natta Catalysts.

The addition of two-dimensional inorganic nanomaterials can effectively enhance the properties of polyethylene (PE). In the present study, a series of high-performance PE/oleic acid (OA)-siloxene nanocomposites were prepared by in situ polymerization using OA-siloxene-supported Ziegler-Natta catalysts. Compared with the conventional Ziegler-Natta catalyst, the polymerization activity of the OA-siloxene-supported Ziegler-Natta catalyst was enhanced to 100 kg/mol-Ti•h, an increase of 56%.

Phenotypic comparison and the potential antitumor function of immortalized bone marrow-derived macrophages (iBMDMs).

Introduction: Macrophages are an important component of innate immunity and involved in the immune regulation of multiple diseases. The functional diversity and plasticity make macrophages to exhibit different polarization phenotypes after different stimuli. During tumor progression, the M2-like polarized tumor-associated macrophages (TAMs) promote tumor progression by assisting immune escape, facilitating tumor cell metastasis, and switching tumor angiogenesis.

[Role of mitochondrial dynamics in diabetic cardiomyopathy and regulatory mechanisms].

Cardiovascular complications are the leading cause of death in diabetic patients. Among them, diabetic cardiomyopathy (DCM) is a type of specific cardiomyopathy excluding myocardial damage caused by hypertension and coronary heart disease. It is characterized by abnormal metabolism of cardiomyocytes and gradual decline of cardiac function.

IPR1-mediated MAMs formation contributes to mechanical trauma-induced hepatic injury and the protective effect of melatonin.

Introduction: There is a high morbidity and mortality rate in mechanical trauma (MT)-induced hepatic injury. Currently, the molecular mechanisms underlying liver MT are largely unclear. Exploring the underlying mechanisms and developing safe and effective medicines to alleviate MT-induced hepatic injury is an urgent requirement.

Core-Shell FeO@C Nanoparticles as Highly Effective T Magnetic Resonance Imaging Contrast Agents: In Vitro and In Vivo Studies.

Magnetite nanoparticles (FeO NPs) have been intensively investigated because of their potential biomedical applications due to their high saturation magnetization. In this study, core-shell FeO@C NPs (core = FeO NPs and shell = amorphous carbons, d = 35.1 nm) were synthesized in an aqueous solution.

Production, surface modification, physicochemical properties, biocompatibility, and bioimaging applications of nanodiamonds.

Nanodiamonds (ND) are chemically inert and stable owing to their sp covalent bonding structure, but their surface sp graphitic carbons can be easily homogenized with diverse functional groups oxidation, reduction, hydrogenation, amination, and halogenation. Further surface conjugation of NDs with hydrophilic ligands can boost their colloidal stability and functionality. In addition, NDs are non-toxic as they are made of carbons.

Study of the Antimicrobial Activity of the Chinese Dong Ethnic Minority Medicine, Madeng'ai.

The overuse of antibiotics has contributed to the emergence of multidrug-resistant bacteria, which poses a challenging task for clinical therapy. Thus, new agents with antibiotic efficacy against multidrug-resistant infections are needed. The traditional Dong ethnic minority medicines have emerged as a new source for prodrug selection.

Mono and Multiple Tumor-Targeting Ligand-Coated Ultrasmall Gadolinium Oxide Nanoparticles: Enhanced Tumor Imaging and Blood Circulation.

Hydrophilic and biocompatible PAA-coated ultrasmall GdO nanoparticles (d = 1.7 nm) were synthesized and conjugated with tumor-targeting ligands, i.e.

Polyethylenimine-Coated Ultrasmall Holmium Oxide Nanoparticles: Synthesis, Characterization, Cytotoxicities, and Water Proton Spin Relaxivities.

Water proton spin relaxivities, colloidal stability, and biocompatibility of nanoparticle magnetic resonance imaging (MRI) contrast agents depend on surface-coating ligands. In this study, hydrophilic and biocompatible polyethylenimines (PEIs) of different sizes (M = 1200 and 60,000 amu) were used as surface-coating ligands for ultrasmall holmium oxide (HoO) nanoparticles. The synthesized PEI1200- and PEI60000-coated ultrasmall HoO nanoparticles, with an average particle diameter of 2.

LINC02154 promotes the proliferation and metastasis of hepatocellular carcinoma by enhancing SPC24 promoter activity and activating the PI3K-AKT signaling pathway.

Background: Abnormal expression of long non-coding RNAs (lncRNAs) has been associated with the initiation and progression of hepatocellular carcinoma but, as yet, the clinicopathologic significance and potential role of Linc02154 in HCC remains to be determined. Here, we aimed to investigate the potential role and mode of action of Linc02154 in HCC.

Methods: The expression of Linc02154 in 20 pairs of HCC/normal tissues and 7 HCC cell lines was detected by qRT-PCR.

Enhanced Tumor Imaging Using Glucosamine-Conjugated Polyacrylic Acid-Coated Ultrasmall Gadolinium Oxide Nanoparticles in Magnetic Resonance Imaging.

Owing to a higher demand for glucosamine (GlcN) in metabolic processes in tumor cells than in normal cells (i.e., GlcN effects), tumor imaging in magnetic resonance imaging (MRI) can be highly improved using GlcN-conjugated MRI contrast agents.

Gadolinium Neutron Capture Therapy (GdNCT) Agents from Molecular to Nano: Current Status and Perspectives.

Gd (natural abundance = 15.7%) has the highest thermal neutron capture cross section (σ) of 254,000 barns (1 barn = 10 m) among stable (nonradioactive) isotopes in the periodic table. Another stable isotope, Gd (natural abundance = 14.

Biosynthesis, regulation, and engineering of natural products from .

Covering: up to August 2021 is a genus of Gram-negative bacteria that was classified in 1987. Several species are emerging as new biocontrol agents for crop protection in agriculture. are prolific producers of new bioactive natural products that are largely underexplored.

Functionalized Lanthanide Oxide Nanoparticles for Tumor Targeting, Medical Imaging, and Therapy.

Recent progress in functionalized lanthanide oxide (LnO) nanoparticles for tumor targeting, medical imaging, and therapy is reviewed. Among the medical imaging techniques, magnetic resonance imaging (MRI) is an important noninvasive imaging tool for tumor diagnosis due to its high spatial resolution and excellent imaging contrast, especially when contrast agents are used. However, commercially available low-molecular-weight MRI contrast agents exhibit several shortcomings, such as nonspecificity for the tissue of interest and rapid excretion in vivo.

Synthesis, Characterizations, and 9.4 Tesla T MR Images of Polyacrylic Acid-Coated Terbium(III) and Holmium(III) Oxide Nanoparticles.

Polyacrylic acid (PAA)-coated lanthanide oxide (LnO) nanoparticles (NPs) (Ln = Tb and Ho) with high colloidal stability and good biocompatibility were synthesized, characterized, and investigated as a new class of negative (T) magnetic resonance imaging (MRI) contrast agents at high MR fields. Their r values were appreciable at a 3.0 T MR field and higher at a 9.

Outer Membrane Vesicle-Mediated Codelivery of the Antifungal HSAF Metabolites and Lytic Polysaccharide Monooxygenase in the Predatory .

are new biocontrol agents known for their prolific production of lytic enzymes and bioactive metabolites. is a predator of fungi and produces several structurally distinct antimicrobial compounds, such as the antifungal HSAF (heat stable antifungal factor) and analogs. The mechanism by which interacts with fungal prey is not well understood.

Chitosan Oligosaccharide Lactate-Coated Ultrasmall Gadolinium Oxide Nanoparticles: Synthesis, Cytotoxicity, and Relaxometric Properties.

In this study, hydrophilic and biocompatible chitosan oligosaccharide lactate (COL)-coated ultra-small gadolinium oxide nanoparticles (NPs) were synthesized through a one-pot polyol method and characterized by various experimental techniques. The cellular cytotoxicity assay indicated that the COL-coated gadolinium oxide NPs were non-toxic up to 500 M Gd. In addition, their water proton spin relaxivities (i.

Hydrophilic Biocompatible Poly(Acrylic Acid-co-Maleic Acid) Polymer as a Surface-Coating Ligand of Ultrasmall GdO Nanoparticles to Obtain a High r Value and T MR Images.

The water proton spin relaxivity, colloidal stability, and biocompatibility of nanoparticle-based magnetic resonance imaging (MRI) contrast agents depend on the surface-coating ligands. Here, poly(acrylic acid-co-maleic acid) (PAAMA) (M = ~3000 amu) is explored as a surface-coating ligand of ultrasmall gadolinium oxide (GdO) nanoparticles. Owing to the numerous carboxylic groups in PAAMA, which allow its strong conjugation with the nanoparticle surfaces and the attraction of abundant water molecules to the nanoparticles, the synthesized PAAMA-coated ultrasmall GdO nanoparticles (d = 1.

New Class of Efficient T Magnetic Resonance Imaging Contrast Agent: Carbon-Coated Paramagnetic Dysprosium Oxide Nanoparticles.

Nanoparticles are considered potential candidates for a new class of magnetic resonance imaging (MRI) contrast agents. Negative MRI contrast agents require high magnetic moments. However, if nanoparticles can exclusively induce transverse water proton spin relaxation with negligible induction of longitudinal water proton spin relaxation, they may provide negative contrast MR images despite having low magnetic moments, thus acting as an efficient T MRI contrast agent.

Ultrasmall Europium, Gadolinium, and Dysprosium Oxide Nanoparticles: Polyol Synthesis, Properties, and Biomedical Imaging Applications.

Imaging agents are crucial in diagnosing diseases. Ultrasmall lanthanide oxide (LnO) nanoparticles (NPs) (Ln = Eu, Gd, and Dy) are promising materials as high-performance imaging agents because of their excellent magnetic, optical, and X-ray attenuation properties which can be applied as magnetic resonance imaging (MRI), fluorescence imaging (FI), and X-ray computed tomography (CT) agents, respectively. Ultrasmall LnO NPs (Ln = Eu, Gd, and Dy) are reviewed here.

In Vivo Positive Magnetic Resonance Imaging Applications of Poly(methyl vinyl ether-alt-maleic acid)-coated Ultra-small Paramagnetic Gadolinium Oxide Nanoparticles.

The study of ultra-small paramagnetic gadolinium oxide (GdO) nanoparticles (NPs) as in vivo positive (T) magnetic resonance imaging (MRI) contrast agents is one of the most attractive fields in nanomedicine. The performance of the GdO NP imaging agents depends on the surface-coating materials. In this study, poly(methyl vinyl ether-alt-maleic acid) (PMVEMA) was used as a surface-coating polymer.

D-Glucuronic Acid-Coated Ultrasmall Bi₂O₃ Nanoparticles for CT Imaging.

Ultrasmall Bi₂O₃ nanoparticles ( = 1.5 nm) coated with biocompatible and hydrophilic D-glucuronic acid were prepared for the first time through a simple one-step polyol process and their potential as CT contrast agents were investigated by measuring their X-ray attenuation properties. Their observed X-ray attenuation power was stronger than that of a commercial iodine CT contrast agent at the same atomic concentration, as consistent with the magnitudes of atomic X-ray attenuation coefficients (i.

neutron capture therapy of cancer using ultrasmall gadolinium oxide nanoparticles with cancer-targeting ability.

Gadolinium neutron capture therapy (GdNCT) is considered as a new promising cancer therapeutic technique. Nevertheless, limited GdNCT applications have been reported so far. In this study, surface-modified ultrasmall gadolinium oxide nanoparticles (UGNPs) with cancer-targeting ability ( = 1.