Relative peripheral refractive errors in Chinese children with myopic anisometropia.

Aim: To compare relative peripheral refractive errors (RPREs) in Chinese children with and without myopic anisometropia (MAI) and to explore the relationship between RPRE and myopia.

Methods: This observational cross-sectional study included 160 children divided into two groups according to the interocular spherical equivalent refraction (SER) difference ≥1.0 D in the MAI group (=80) and <1.

Observation of peripheral refraction in myopic anisometropia in young adults.

Aim: To investigate the differences in retinal refraction difference values (RDVs) of adult patients with myopic anisometropia compared with those without myopic anisometropia, and to investigate the relationship between ocular biometric measurements and relative peripheral refraction.

Methods: This clinical observation study included 130 patients with myopia (-0.25 to -10.

[Varieties systematization and standards status analysis of fermented Chinese medicine].

Fermented Chinese medicine has long been used. Amid the advance for preservation of experience, the connotation of fermented Chinese medicine has been enriched and improved. However, fermented Chinese medicine prescriptions generally contain a lot of medicinals.

[Reflections on supervision strategies of new Tibetan drug registration].

Tibetan medicine is an essential part of Chinese medicine and has unique theoretical experience and therapeutic advantages. According to the development principle of inheriting the essence, sticking to the truth, and keeping innovative, the supervision department should give clear and reasonable guidance considering the characteristics of Tibetan medicine, establish a standard system for quality control, clinical verification and evaluation, and accelerate the research and commercialization of new drugs. In view of the needs of drug supply-side reform and the current situation of Tibetan medicine and new pharmaceutical research, we ponder and provide suggestions on the confusion faced by the current supervision of Tibetan drug registration, hoping to contribute to the supervision strategy of Tibetan drug registration and the high-quality development of Tibetan medicine industry.

Targeted bile acid profiles reveal the liver injury amelioration of Da-Chai-Hu decoction against ANIT- and BDL-induced cholestasis.

Multiple types of liver diseases, particularly cholestatic liver diseases (CSLDs) and biliary diseases, can disturb bile acid (BA) secretion; however, BA accumulation is currently seen as an important incentive of various types of liver diseases' progression. Da-Chai-Hu decoction (DCHD) has long been used for treating cholestatic liver diseases; however, the exact mechanisms remain unclear. Currently, our study indicates that the liver damage and cholestasis status of the α-naphthylisothiocyanate (ANIT)-induced intrahepatic cholestasis and bile duct ligation (BDL)-induced extrahepatic cholestasis, following DCHD treatment, were improved; the changes of BA metabolism post-DCHD treatment were investigated by targeted metabolomics profiling by UPLC-MS/MS.

Corneal epithelial remodeling after femtosecond laser-assisted in situ keratomileusis combined with intraoperative accelerated corneal collagen crosslinking for myopia: a retrospective study.

Background: This study analyzed regional corneal thickness remodeling, biomechanical properties, and visual outcomes after femtosecond laser-assisted in situ keratomileusis combined with intraoperative accelerated corneal collagen crosslinking (LASIK Xtra) for myopia.

Methods: This retrospective study analyzed 21 consecutive patients (18 women, three men; 42 eyes) who were treated with LASIK Xtra. All treatments were performed with ultraviolet-A (energy, 2.

Comparison of clinical outcome of small-incision lenticule intrastromal keratoplasty and FS-LASIK for correction of moderate and high hyperopia.

Aim: To compare the clinical outcome of small-incision lenticule intrastromal keratoplasty (sLIKE) and femtosecond laser-assisted keratomileusis (FS-LASIK) for correction of moderate and high hyperopia.

Methods: A case-controlled clinical study was performed. Twenty right eyes of 20 moderate and high hyperopia patients underwent sLIKE (sLIKE group) and 22 right eyes of 22 moderate and high hyperopia patients underwent FS-LASIK (FS-LASIK group) were enrolled in this study from October 2015 to October 2017.

[Current situation and problems of national standards for Chinese medicinal materials].

To learn the current situation and strengthen the management of national standards for Chinese medicinal materials, we sorted out the relevant national standards. According to incomplete statistics, there are 1 185 kinds of Chinese medicinal materials, including 1 024 kinds of plant medicines, 106 kinds of animal medicines, and 54 kinds of mineral medicines, in addition to ethnic medicinal materials with different functions. The relevant standards include 819 Pharmacopoeia standards, 342 standards issued by the Ministry of Health or National Medicinal Products Administration, 7 standards for new medicinal materials, and 17 standards for imported medicinal materials.

[Research and development strategies of new Chinese medicines based on new regulations].

In recent years, only a small number of new Chinese medicines have been approved for marketing, which has embodied the bottleneck in the development of the Chinese medicine industry. To tackle this problem, the National Medical Products Administration has issued a series of regulations and technical requirements. In the context of new regulations, this study deeply explored the research and development strategies of new Chinese medicines under the guidance of the new classification of drug registration, and discussed the key technical issues in the research and development.

Evaluation of preoperative dry eye in people undergoing corneal refractive surgery to correct myopia.

Aim: To investigate the incidence of preoperative dry eye and related factors in patients undergoing corneal refractive surgery to correct myopia.

Methods: A total of 141 patients with myopia who underwent corneal refractive surgery were surveyed by questionnaires, tear film break-up time (BUT) test, Schimer I test (SIt), corneal fluorescein staining (FL) test and diagnosed according to the currently recognized domestic diagnostic criteria for dry eye. Correlation analysis of factors such as age, gender, regular wearing of contact lens (CL), diopter (spherical equivalent), corneal thickness, and corneal curvature that may affect the onset of dry eye was carried out to clarify the main influencing factors.

Comparison of visual performance recovery after thin-flap LASIK with 4 femtosecond lasers.

Aim: To compare the speed of visual recovery following myopic thin-flap LASIK with four femtosecond lasers.

Methods: Eighty-eight eyes of 46 patients who were consecutively scheduled for bilateral LASIK with the IntraLase FS60 (Group 1), Femto LDV Crystal Line (Group 2), Wavelight FS200 (Group 3) and VisuMax (Group 4) femtosecond lasers were enrolled in. Monocular uncorrected distance visual acuity (UDVA), best-corrected distant visual acuity (CDVA), refraction, contrast sensitivity and higher-order aberrations (HOAs) were evaluated at 1, 3d, 1wk and 1mo postoperatively.

Effects of higher-order aberrations on contrast sensitivity in normal eyes of a large myopic population.

Aim: To study the relation between higher-order aberrations (HOAs) and contrast sensitivity (CS) in normal eyes among a population of laser keratomileusis (LASIK) candidates.

Methods: In 6629 eyes of 3315 LASIK candidates, CS were measured under dark environment at the spatial frequencies of 1.5, 3, 6, 12 and 18 cycles per degree (c/d), respectively, using an Optec 6500 visual function tester.

Analysis of Macular and Retinal Nerve Fiber Layer Thickness in Children with Refractory Amblyopia after Femtosecond Laser-assisted Laser Keratomileusis: A Retrospective Study.

Background:: Localized macular edema and retinal nerve fiber layer (RNFL) thinning have been reported shortly after laser in situ keratomileusis (LASIK) in adults. However, it is still unclear how LASIK affects the retina of children. This study aimed to investigate the macular retina and RNFL thickness in children with refractive amblyopia who underwent femtosecond laser-assisted LASIK (FS-LASIK).

Effect of femtosecond and microkeratome flaps creation on the cornea biomechanics during laser keratomileusis: one year follow-up.

Aim: To compare the corneal biomechanical outcomes at one year after laser keratomileusis (LASIK) with the flaps created by Ziemer and Moria M2 microkeratome with 110 head and -20 blade.

Methods: Totally 100 eyes of 50 consecutive patients were enrolled in this prospective study and divided into two groups for corneal flaps created by ZiemerFemto LDV and Moria M2 microkeratome with 110 head and -20 blade. Corneal biomechanical properties including cornea resistance factor (CRF) and cornea hysteresis (CH) were measured before and 1, 3, 6, 12mo after surgery by ocular response analyzer.

Comparison of corneal flaps created by Wavelight FS200 and Intralase FS60 femtosecond lasers.

Aim: To assess and compare the morphology of corneal flaps created by the Wavelight FS200 and Intralase FS60 femtosecond lasers in laser in situ keratomileusis (LASIK).

Methods: Four hundred eyes of 200 patients were enrolled in this study and divided into Wavelight FS200 groups (200 eyes) and Intralase FS60 groups (200 eyes). Fourier-domain optical coherence tomography (RTVue OCT) was used to measure the corneal flap thickness of 36 specified measurements on each flap one week after surgery.

Comparison of Visual Outcomes After Femtosecond LASIK, Wave Front-Guided Femtosecond LASIK, and Femtosecond Lenticule Extraction.

Purpose: To compare the mesopic contrast sensitivity (CS) and higher order aberrations (HOAs) at 3 months after femtosecond-laser in situ keratomileusis (LASIK) (FS-LASIK), wave front-guided femtosecond LASIK (WF-LASIK), and femtosecond lenticule extraction (FLEx) for the correction of myopia and myopic astigmatism.

Methods: In this prospective nonrandomized study, 332 right eyes of 332 patients were treated with FS-LASIK, WF-LASIK, or FLEx. The HOAs and mesopic CS were evaluated preoperatively and at 3 months postoperatively.

Effect of suction on macular thickness and retinal nerve fiber layer thickness during LASIK used femtosecond laser and Moria M2 microkeratome.

Aim: To compare the effect of suction on the macular thickness and retinal nerve fiber layer (RNFL) thickness during laser in situ keratomileusis (LASIK) used Ziemer FEMTO LDV femtosecond laser (Ziemer group) and Moria M2 automated microkeratome (Moria group) for flap creation.

Methods: Fourier-domain optical coherence tomography (FD-OCT) was used to measure macular thickness, ganglion cell complex thickness and (RNFL) thickness of 204 eyes of 102 patients with the Ziemer femtosecond laser (102 eyes) and the Moria M2 microkeratome (102 eyes) before surgery and 30min; 1, 3d; 1wk; 1, 3mo; 1y after surgery.

Results: The average foveal thickness and parafoveal retinal thickness 30min after the surgery were statistically more than that before surgery (Ziemer P<0.

Effect of undercorrection on myopia progression in 12-year-old children.

Background: To prospectively observe the effects of undercorrection of myopia on myopia progression and axial elongation in a population of 12-year-old Chinese children.

Methods: A total of 2,267 children in the Anyang Childhood Eye Study were examined at baseline, and 1,769 were followed for 1 year. Ocular examinations included cycloplegic autorefraction, axial length, visual acuity, vertometry, and accommodative lag.

Distribution of ocular biometry in 7- and 14-year-old Chinese children.

Purpose: To describe distributions of ocular biometry and their associations with refraction in 7- and 14-year-old children in urban areas of Anyang, central China.

Methods: A total of 2271 grade 1 students aged 7.1 ± 0.

Peripheral refraction in 7- and 14-year-old children in central China: the Anyang Childhood Eye Study.

Purpose: To determine the distribution of peripheral refraction, including astigmatism, in 7- and 14-year-old Chinese children.

Methods: 2134 7-year-old and 1780 14-year-old children were measured with cycloplegic central and horizontal peripheral refraction (15° and 30° at temporal and nasal visual fields).

Results: 7- and 14-year-old children included 9 and 594, respectively, with moderate and high myopia (≤-3.

Comparison of Ziemer FEMTO LDV "Classic" and "Crystal Line" femtosecond laser flap quality by Fourier-domain optical coherence tomography.

Aim: To compare the regularity and accuracy of laser in situ keratomileusis (LASIK) flaps created by the Ziemer FEMTO LDV "Classic" (Ziemer "Classic") and Ziemer FEMTO LDV Crystal Line femtosecond laser (Ziemer Crystal Line).

Methods: Fourier-domain optical coherence tomography (RTVue OCT) was used to measure the morphology of 200 LASIK flaps of 100 consecutive patients created with the Ziemer Classic (100 flaps) or the Ziemer Crystal Line (100 flaps) at one week postoperatively. Flap thickness was evaluated at 36 specified measurement points on each flap.

Visual performance after conventional LASIK and wavefront-guided LASIK with iris-registration: results at 1 year.

Aim: To compare visual performance of wavefront-guided laser in situ keratomileusis (LASIK) with iris-registration (Wg-LASIK group) and conventional LASIK (LASIK group) one year after surgery and analyze the correlation between wavefront aberrations and visual performance.

Methods: Eight hundred and fifty-two myopic eyes of 430 patients were enrolled in this prospective study and divided into two groups: Wg-LASIK group (436 eyes) and LASIK group (416 eyes). A Wavescan Wavefront aberrometer was used to analyze Zernike coefficients and the root-mean-square (RMS) of higher order aberrations, and Optec 6500 visual function instrument was used to measure contrast sensitivity (CS) before and 3, 6, 12 months after surgery.

Comparison of the flaps made by femtosecond laser and automated keratomes for sub-bowman keratomileusis.

Background: Thin-flap laser in situ keratomileusis (LASIK) is the new trend of refractive error correction surgery, the formation of corneal flap is crucial for a success of LASIK surgery. This study aimed to assess and compare the variations of LASIK flap created by the IntraLase femtosecond laser, Moria One Use-Plus SBK and Moria M2 Single-Use 90 µm-head microkeratome using Anterior segment optical coherence tomography (Visante OCT).

Methods: One hundred and sixty-one eyes of 81 consecutive patients were enrolled in this prospective study and randomly divided into three groups depending on the flap creation method: flap creation with the the IntraLase femtosecond laser (IntraLase group, 59 eyes), flap creation with the Moria One Use-Plus SBK (SBK group, 44 eyes), and flap creation with the Moria M2 Single-Use 90 µm-head microkeratome (M2SU90 group, 58 eyes).

[Effects of single mode's high-order aberrations on visual acuity corrected using adaptive optics technique].

Objective: To analyze the effects of single mode's high-order aberration on visual acuity in real time dynamically corrected using adaptive optics technique.

Methods: Control study. In a dark room, twelve young healthy volunteers were administrated with 5 g/L phenylephrine to fully dilate the right eye's pupil to a diameter over 6 mm.