Publications by authors named "Yue Hua Wang"

Article Synopsis
  • The NLRP3 inflammasome is crucial in inflammatory diseases, and its activation is influenced by mitochondrial damage and oxidative stress.
  • The study shows that Nepetin (Nep), a natural flavonoid, enhances the process of mitophagy and inhibits NLRP3 inflammasome activation in macrophages, showcasing its antioxidant effects.
  • In mice with systemic inflammation or obesity, Nep improved survival, reduced organ damage, and lowered inflammation, supporting its potential as a therapeutic anti-inflammatory agent.
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Glioblastoma represents the predominant and a highly aggressive primary neoplasm of the central nervous system that has an abnormal metabolism. Our previous study showed that chrysomycin A (Chr-A) curbed glioblastoma progression in vitro and in vivo. However, whether Chr-A could inhibit orthotopic glioblastoma and how it reshapes metabolism are still unclear.

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  • Dopaminergic neurons in the substantia nigra are particularly prone to damage from rotenone, which contributes to the neuron loss seen in Parkinson's disease, and baicalein has potential neuroprotective effects.
  • In experiments with SH-SY5Y cells, baicalein was shown to enhance K-ATP channel activity and counteract the harmful effects of rotenone by dealing with reactive oxygen species and mitochondrial dysfunction.
  • The study indicates that baicalein binds strongly to the SUR1 protein, which is involved in K-ATP channels, suggesting it could be a valuable target for preventing neuron degeneration in Parkinson's disease.
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Glioblastoma (GBM) is a major type of primary brain tumor without ideal prognosis and it is therefore necessary to develop a novel compound possessing therapeutic effects. Chrysomycin A (Chr-A) has been reported to inhibit the proliferation, migration and invasion of U251 and U87-MG cells through the Akt/GSK-3β signaling pathway, but the mechanism of Chr-A against glioblastoma in vivo and whether Chr-A modulates the apoptosis of neuroglioma cells is unclear. The present study aims to elucidate the potential of Chr-A against glioblastoma in vivo and how Chr-A modulates the apoptosis of neuroglioma cells.

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Huan C. Wang & Feng Yang, a new species of Caryophyllaceae, is here described and illustrated based on morphological and molecular evidence. The new species was found in Sichuan and Yunnan provinces, southwest China.

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Surgical resection is the most common approach for the treatment of osteosarcoma. However, two major complications, including residual tumor cells and large bone defects, often arise from the surgical resection of osteosarcoma. Discovering new strategies for programmatically solving the two above-mentioned puzzles has become a worldwide challenge.

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Article Synopsis
  • The common walnut (Juglans regia) is valued for its wood and nuts, with the Iranian Plateau being a key area for its genetic diversity and domestication.
  • SSR markers were used to analyze 508 walnut individuals across 27 populations, revealing high genetic diversity with more variation within populations than between them.
  • The study highlights the importance of conserving certain populations, particularly the low-diversity one in Iraq, and recommends preservation efforts for specific populations in Iran to maintain genetic resources.
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Kaempferol, a natural plant flavonoid compound, has a neuroprotective effect on ischemic stroke, while the specific mechanism remains unclear. In the current study, we applied the comprehensive strategy that combines network pharmacology and experimental evaluation to explore the potential mechanism of kaempferol in the treatment of cerebral ischemia. First, network pharmacology analysis identified the biological process of kaempferol, suggesting that kaempferol may partly help in treating ischemic stroke by regulating apoptosis and inflammatory response.

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Chrysomycin A (Chr-A), an antibiotic from Streptomyces, is reported to have anti-tumor and anti-tuberculous activities, but its anti-glioblastoma activity and possible mechanism are not clear. Therefore, the current study was to investigate the mechanism of Chr-A against glioblastoma using U251 and U87-MG human cells. CCK8 assays, EdU-DNA synthesis assays and LDH assays were carried out to detect cell viability, proliferation and cytotoxicity of U251 and U87-MG cells, respectively.

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Increasing severity of drought stress due to global change and extreme weather has been affecting the biodiversity, function, and stability of forest ecosystems. However, despite being an important component in the alpine and subalpine vegetation in forest ecosystems, species have been paid rare attention in the study of molecular mechanism of tolerance or response to drought. Herein, we investigated the correlation of transcriptomic changes with the physiological and biochemical indicators of under drought stress by using the co-expression network approach and regression analysis.

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Neuroinflammation characterized by microglia activation is the mechanism of the occurrence and development of various central nervous system diseases. ST2825, as a peptide-mimetic MyD88 homodimerization inhibitor, has been identified as crucial molecule with an anti-inflammatory role in several immune cells, especially microglia. The purpose of the study was to investigate the anti-neuroinflammatory effects and the possible mechanism of ST2825.

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The mechanism underlying the hypoglycemic effect of the simultaneous use of metformin and anthocyanin-rich foods is not yet clear. Hence, the effects and possible mechanisms of action of these substances, alone and in combination, were evaluated in insulin-resistant HepG2 cells and a diabetic mouse model. The results indicated that anthocyanin and metformin had a significant synergistic effect on glucose consumption (CI < 0.

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In this study, we determined the complete chloroplast genome of (Cycadaceae), one of the first-class protected plants in China. The chloroplast genome is 162,048 bp in length with 133 genes, including 87 protein-coding genes, eight ribosomal RNA genes, and 37 transfer RNA genes. The overall GC content is 39.

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Understanding the molecular mechanisms and evolutionary process of plant adaptation to the heterogeneous environment caused by altitude gradients in plateau mountain ecosystems can provide novel insight into species' responses to global changes. Flower color is the most conspicuous and highly diverse trait in nature. Herein, the gene expression patterns, evolutionary adaptation and metabolites changes of different-colored flowers of alpine Rhododendron L.

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TLR4 signal activated by lipopolysaccharide (LPS) is involved in the pathological process of the central nervous system (CNS) diseases and the suppression of TLR4 signal may become an effective treatment. TLR4-IN-C34, a TLR4 inhibitor, is expected to become a candidate compound with anti-neuroinflammatory response. In the present study, the anti-neuroinflammatory effects and possible mechanism of TLR4-IN-C34 were investigated in BV2 microglia cells stimulated by LPS.

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Background: Aesculin (AES), an effective component of Cortex fraxini, is a hydroxycoumarin glucoside that has diverse biological properties. The nucleotide-binding domain leucine-rich repeat-containing receptor, pyrin domain-containing 3 (NLRP3) inflammasome has been heavily interwoven with the development of myocardial ischemia/reperfusion injury (MIRI). Nevertheless, it remains unclear whether AES makes a difference to the changes of the NLRP3 inflammasome in MIRI.

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Article Synopsis
  • Walnuts are in high demand for their nutritional benefits and medicinal uses, prompting intensified breeding efforts in areas like southwest China to create better cultivars.
  • Researchers genotyped 362 walnut tree samples (including both cultivated and wild) using microsatellite markers, revealing low genetic diversity and high clonality among cultivars, suggesting a narrow genetic base for breeding.
  • The study identified a key genetic group linked to the 'Yangbidapao' landrace and emphasized the need to incorporate more diverse genetic sources, including wild walnuts, to enhance breeding programs and conservation efforts in the region.
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RKC-B1 is a novel fermentation product obtained from the marine micromonospora FIM02-523A. Thus far, there have been few reports about the pharmacological activity of RKC-B1. In our present study, we investigated the anti-neuroinflammatory effects and the possible mechanism of RKC-B1 in LPS-stimulated mice.

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Chrysomycin A (Chr-A), an antibiotic chrysomycin, was discovered in 1955 and is used to treat cancer and tuberculosis. In the present study, the anti-neuroinflammatory effects and possible mechanism of Chr-A in BALB/c mice and in BV2 microglia cells stimulated by lipopolysaccharide (LPS) were investigated. Firstly, the cortex tissues of mice were analyzed by RNA-seq transcriptome to identify differentially expressed genes (DEGs) regulated by Chr-A in LPS-stimulated mice.

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Article Synopsis
  • The study focuses on a rare plant from southwest China, detailing the assembly and analysis of its complete chloroplast genome using advanced sequencing techniques.
  • The chloroplast genome is circular, measuring 158,713 base pairs, with a GC content of 36.6%, featuring typical structures, including inverted repeats and single-copy regions.
  • A total of 132 genes were identified in the genome, emphasizing its genetic makeup, and the phylogenetic analysis showed the plant's close relation to another species, which may aid in future research and conservation efforts.
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R.L. Liao & Lei Cai, a new species from Southeast Yunnan, China, is here described and illustrated.

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Background: The Rhododendron sanguineum complex is endemic to alpine mountains of northwest Yunnan and southeast Tibet of China. Varieties in this complex exhibit distinct flower colors even at the bud stage. However, the underlying molecular regulations for the flower color variation have not been well characterized.

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Objective: The aim of the present study was to evaluate the performance of the simultaneous detection of HIV-1 RNA, HIV-1 DNA, and HCV RNA using one dried blood spot (DBS) as an alternative sample to plasma.

Method: A total of 571 paired DBS/plasma samples were collected from men who have sex with men (MSM) and injection drug users (IDUs), and serological and molecular assays were performed. Using plasma results as the reference standard, the performance of DBS tests for HIV-1 RNA, HIV-1 DNA, and HCV RNA was evaluated.

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