Modulation Mechanism of ZnO/P-Si Contact Electrification by Ultraviolet-Excited Photocarriers in Contact-Electro-Junction.

Self-powered ultraviolet (UV) photodetector devices are considered as one of the development trends of UV photodetector devices. The triboelectric nanogenerator (TENG) has great application prospects in the field of self-powered UV photodetection. However, the modulation mechanism of contact electrification (CE) by UV light is unclear at present, which makes the application of the TENG on UV photoelectric detectors difficult.

Identification of potential drug targets for pelvic organ prolapse using a proteome-wide Mendelian randomization approach.

Pelvic organ prolapse (POP) significantly impacts patients' quality of life, and current treatment options remain limited due to high recurrence rates, making the exploration of new therapeutic targets essential. Using data from the FinnGen cohort, we performed a proteome-wide Mendelian randomization (PW-MR) analysis. Through PW-MR and Bayesian colocalization analyses, we identified EFEMP1 and MFAP4 as potential key drug targets, with EFEMP1 potentially exerting a protective effect, whereas MFAP4 may be associated with an increased risk of POP.

Plac1 Tumor Cell-Treg Interplay Supports Tumorigenesis and Progression of Head and Neck Cancer.

Cancer/testis antigen (CTA) family is restricted to germline and tumor cells and plays an important role during cancer initiation and progression. Five single-cell and two bulk RNA-seq datasets are integrated to screen genes in the CTAs family, revealing that Placenta specific protein 1 (Plac1) is specifically expressed in head and neck squamous cell carcinoma (HNSCC) cells. Sp1 Transcription (SP1) is identified as a specific regulator of Plac1, which is confirmed by cleavage under targets and tagmentation (CUT&Tag)-seq.

Facilitation of mucosal healing by estrogen receptor in ulcerative colitis through suppression of branched-chain amino acid transport and subsequent triggering of autophagy in colonic epithelial cells.

Colonic mucosal healing is the ultimate goal of ulcerative colitis (UC) treatment, but it remains difficult to realize. Given the higher incidence of UC in males and the beneficial effect of estrogen on UC, we conducted this study to examine the therapeutic potential of estrogen receptor (ER), the primary ER subtype in colon, on mucosal healing in UC. Our study is the first to report that ER activation degree was positively correlated with mucosal healing in patients with UC.

Direct synthesis of high quantum yield lead-free CsCuI powder in water and its application in yellow LED.

Yellow light-emitting diodes (LEDs) with a wavelength of 570-590 nm can reduce the excitability of peripheral nerves and the sensitivity of the skin, stimulate collagen synthesis, and tighten the skin, which plays an important role in skin rejuvenation. In general, commercial LEDs are made of phosphor excited by ultraviolet chips. It is very important for the development of yellow light emitters with high luminous efficiency, good stability, and environmental protection.

An Arterial Pulse Signal Acquiring Wristwatch with Flexible Tactile Sensing Dense-Array.

This study reports a wristwatch to automatically acquire the arterial pulse signal. A two-dimensional flexible tactile sensing dense-array is integrated in the watch. The dense-array consists of 29 × 3 ultra-small pressure sensing chips, enabling high-resolution tactile perception.

Investigation of vascular morphology prediction based on high dimensional pulse acquisition system and finite element methods.

In this paper, we propose a novel pulse acquisition system based on MEMS technology, where finger-end pressure and micro-sensor array applications are combined to achieve a high degree of integration of multi-channel information at the pulse acquisition end. A static stress analysis model for blood vessels based on the finite element method is proposed, which is used to investigate the effects of the modulus of elasticity of the vessel wall, and the inner diameter of the vessel on the outward pressure. The blood flow patterns of people with different blood pressures were simulated by varying the pressure intensity of the vessel wall.

An Instant Tumor Detection Method for Ex-vivo Tissue Palpation Utilizing Self-learning High-density Flexible Tactile Sensor Array Based on Attention Mechanism Neural Network.

This paper reports an innovative and instant method for tumor detection. We delineate the tactile signal matrixes of tumor tissue with varying stiffness utilizing self-learning high-density flexible tactile sensor array, and depict the morphological features of the tumor at the fingertip tactile perception with an attention mechanism neural network. A novel algorithm to instantaneously recognize the shape and volume of tumor tissue, incorporating an attention mechanism model for autonomous learning of pressure signal characteristics from each sensing unit, is developed in the ex-vivo experiments, for the first time, by delivering the dense sensing array that enables intimate location-stable contact with skin.

Effect of Craniocervical Atherosclerotic Stenosis on the Occurrence of Neurologic Deterioration in Patients With Small Vessel Occlusion Stroke and Their Clinical Outcomes.

Objective: To explore the effects of craniocervical atherosclerotic stenosis (AS) on the occurrence of neurologic deterioration (ND) in patients with small vessel occlusion (SVO) stroke and the outcomes of patients with SVO stroke with ND (SVO-ND).

Methods: Patients with SVO stroke were consecutively enrolled. AS was defined as a craniocervical artery with ≥ 50% stenosis caused by atherosclerosis.

Synthetic microbial community maintains the functional stability of aerobic denitrification under environmental disturbances: Insight into the mechanism of interspecific division of labor.

Understanding how synthetic microbial community (SMC) respond to environmental disturbances is the key to realizing SMC engineering applications. Here, dibutyl phthalate (DBP) and levofloxacin (LOFX) were used as environmental disturbances to study their effects on the aerobic denitrification functional stability of SMC composed of Pseudomonas aeruginosa N2 (PA), Acinetobacter baumannii N1(AC) and Aeromonas hydrophila (AH). The results showed that aerobic denitrification efficiency could be maintained at about 93 % under DBP or LOFX disturbance, and interspecific communication was mainly carried out through N-butyryl-L-homoserine lactone (C-HSL) and N-(3-oxododecanoyl)-L-homoserine lactone (3OC-HSL), correspondingly.

Possible antidepressant mechanism of acupuncture: targeting neuroplasticity.

Major depressive disorder (MDD) is a highly prevalent and severely disabling psychiatric disorder that decreases quality of life and imposes substantial economic burden. Acupuncture has emerged as an effective adjunctive treatment for depression, it regulates neurotransmitters involved in mood regulation and modulates the activity of specific brain regions associated with emotional processing, as evidenced by neuroimaging and biochemical studies. Despite these insights, the precise neuroplastic mechanisms through which acupuncture exerts its antidepressant effects remain not fully elucidated.

Global, regional and national burden and trends of disease attributable to high body mass index in adolescents and young adults from 1990 to 2021.

Background: The burden of high high body mass index (BMI) in adolescent and young adults (AYA) is largely unknown. Therefore, we aim to assess this burden.

Methods: Data were extracted from GBD 2021.

Genetic insights into the relationship between immune cell traits and abnormal uterine bleeding: A Mendelian randomization study.

Abnormal uterine bleeding (AUB) is an inflammatory response involving immune cells, but the relationship between immune cell traits and AUB is highly complex and still largely unclear. This study utilized genetic data from a genome-wide association study of European participants. Mendelian randomization (MR) analysis methods, including inverse variance weighted (IVW) as the primary approach, weighted median, MR Egger regression, and Mendelian randomization pleiotropy residual sum and outlier, were employed for forward and reverse analyses.

A dual-reactivity-based surface-enhanced Raman spectroscopy nanosensor for the simultaneous imaging of hypochlorite and nitric oxide in living cells.

A surface-enhanced Raman spectroscopy (SERS) nanosensor with dual-reactivity is developed for the simultaneous imaging of hypochlorite (ClO) and nitric oxide (NO) in living cells. Utilizing the specific reactions between functional molecules and ClO and NO, respectively, the 2-mercapto-4-methoxy-phenol (2-MP) and o-phenylenediamine (OPD) molecules are synchronously assembled on the surface of gold nanoparticles to fabricate the dual-function nanosensors. The advantages of SERS technology, narrow peaks for spectral multiplexing and fingerprint information, further facilitate the simultaneous detection of ClO and NO.

Revealing the Surface Topography Influence and Fundamental Operating Mechanism on Semiconductor-Semiconductor-Based Tribovoltaic Effect.

Tribovoltaic effect is an emerging phenomenon occurring between two materials, which can generate direct current (DC) rather than alternate current (AC) at the contact interface. Though the existence of a tribovoltaic effect indeed brings up a new method for power supply of critical sensors using the Internet of Things technology, the wear and damage of tribovoltaic materials related to the surface topography during the sliding process is still nonnegligible. In this work, the influence of surface topography on the tribovoltaic effect between semiconductors is investigated by means of a lateral sliding mode triboelectric nanogenerator composed of ZnO and Si (ZnO/Si LS-TENG).

L. ethyl acetate extract regulated angiogenesis in atherosclerosis by modulating the miR-126/VEGF signalling pathway.

Aims Of The Study: To investigate the regulatory mechanism of L. ethyl acetate extract (CSEAE) on angiogenesis in atherosclerosis (AS) based on the miR-126/VEGF signalling pathway.

Materials And Methods: Our study first screened for differentially expressed microRNAs (miRNAs) associated with AS using the Gene Expression Omnibus (GEO) public database at the National Center for Biotechnology Information (NCBI) and R language software.

Investigating the causal relationship between rheumatoid arthritis and cardiovascular disease: A Mendelian randomization study.

Objective: Previous research has revealed a positive correlation between rheumatoid arthritis (RA) and cardiovascular diseases, but the causal relationship is unclear. This study applies Mendelian randomization to examine whether RA causally contributes to the likelihood of various cardiovascular diseases, such as heart failure, coronary artery disease, and atrial fibrillation.

Methods: Using genome-wide association data, we conducted a univariable MR (UVMR) analysis to evaluate the causal impact of RA on CVD, primarily utilizing the inverse variance weighted method.

Tumor-associated macrophages drive heterogenetic CD10 cancer stem cells to implement tumor-associated neutrophils reprogramming in oral squamous cell carcinoma.

Tumor-associated macrophages (TAMs) in the tumor microenvironment (TME) widely participate in the malignant progression in cancer. Previously, we have demonstrated that M1-like TAMs cascaded a stem-like phenotype of oral squamous cell carcinoma (OSCC). Yet, the underlying mechanisms still need to be demonstrated for the regulation of TAMs on cancer stem cells (CSCs) in OSCC.

Relation of volatile organic compounds to renal function in American adolescents: three statistical models.

This study was conducted to evaluate the relationship between 17 urinary metabolites of volatile organic compounds (mVOCs) in adolescents and renal function parameters (estimated glomerular filtration rate (eGFR), albumin-to-creatinine ratio (ACR), urinary albumin, serum uric acid (SUA), and blood urea nitrogen (BUN)). In adjusted generalised linear models (GLM), mVOCs were positively correlated with eGFR, urinary albumin, and BUN, and mVOCs were negatively correlated with ACR and SUA. Weighted Quartile Sum (WQS) index correlated with eGFR [β(95%CI): 0.

A novel allosteric driver mutation of β-glucuronidase promotes head and neck squamous cell carcinoma progression through STT3B-mediated PD-L1 N-glycosylation.

Head and neck squamous cell carcinoma (HNSCC) develops and advances because of the accumulation of somatic mutations located in orthosteric and allosteric areas. However, the biological effects of allosteric driver mutations during tumorigenesis are mostly unknown. Here, we mapped somatic mutations generated from 10 tumor-normal matched HNSCC samples into allosteric sites to prioritize the mutated allosteric proteins via whole-exome sequencing and AlloDriver, identifying the specific mutation H351Q in β-glucuronidase (GUSB), a lysosomal enzyme, as a novel allosteric driver mutation, which considerably encouraged HNSCC progression both in vitro and in vivo.

Pericarpium Trichosanthis Inhibits TGF-β1-Smad3 Pathway-Induced Cardiac Fibrosis in Heart Failure Rats via Upregulation of microRNA-29b.

Cardiac dysfunction and adverse consequences induced by cardiac fibrosis have been well documented. However, the cardiac fibrosis pathway in chronic heart failure (CHF) remains unclear, and it is therefore necessary to conduct further research for the sake of developing more effective therapeutic strategies for CHF. Some recent studies suggest that Pericarpium Trichosanthis (PT) may help improve the progression of fibrotic diseases.

Hypertensive disorders of pregnancy affected thyroid hormone synthesis via endoplasmic reticulum stress in preterm infant rats.

Background: Maternal hypertensive disorders of pregnancy (HDP) was associated with increased risk of congenital hypothyroidism in preterm infants, but its underlying mechanisms remain unclear.

Objective: To investigate the possible mechanisms by which intrauterine exposure to HDP affects thyroid hormone synthesis in preterm infant rats.

Methods: preterm infant rats were obtained by Caesarean section delivery from the L-NAME group and Control groups which was induced by L-NAME and saline, respectively.

The comparison of the risk of neurological deterioration and clinical outcomes in different atherosclerotic stroke patterns.

This study aims to compare the incidences of neurological deterioration (ND) and poor outcome (a modified Ranking scale > 2 points at discharge) among patients with different atherosclerotic stroke patterns. A total of 688 participants were categorized into 4 groups according to atherosclerotic stroke pattern: multiple small infarcts (MSI), single subcortical infarction (SSI), borderzone infarct (BZI) and large infarct groups. Among the 4 groups, MSI group had the lowest incidences of ND and poor outcome (13.

[Relationship between Benggang erosion and landscape pattern in the southern red soil zone based on path analysis].

Benggang (collapsing hill) erosion is one of the most serious ecological problems in the south of China. Understanding the relationship between Benggang erosion and landscape pattern is conducive to the study of Benggang occurrence and development from the perspective of landscape ecology, with great significance for Benggang prevention and ecological protection. We classified the Lanxi River Basin in Anxi County, Fujian Province into 32 small watersheds.

Fibula flap reconstruction for maxillary stage 3 medication-related osteonecrosis of the jaw from recipient and donor site perspectives: a preliminary single-center study.

Background: While the surgical treatment of mandibular stage 3 medication-related osteonecrosis of the jaw (MRONJ) is well-documented, research on maxillary stage 3 MRONJ is limited. Antiresorptive medications can induce MRONJ and atypical femoral fracture (AFF), but their impact on the feasibility of using fibula flaps for reconstruction remains controversial. This study aimed to assess the surgical outcomes and functional recovery of fibula flap reconstruction for maxillary stage 3 MRONJ, considering both recipient and donor site outcomes.