Application of chain body temperature management checklist in robotic surgery for urology: a randomised controlled trial.

Objective: To explore the management effect of a chain temperature management checklist in preventing hypothermia in patients undergoing urological robotic surgery during the perioperative period.

Methods: A total of 152 patients undergoing urological robotic surgery were enrolled in this study between March and September 2021 and again between March and September 2022. All patients were randomly divided into the control group (n = 76) and the intervention group (n = 76).

Nanoparticle delivery of CD68 siRNA inhibits neuroimmune responses by inhibiting activation of M1 macrophages.

CD68 is a vital costimulatory molecule expressed on macrophages/microglia (M/Ms) and plays a critical role in their activation. By targeting this molecule, therapeutic interventions can potentially prevent the homing of M/Ms. to the lesion site.

Gestational Weight Gain as a Modifiable Factor for the Impact of Pre-conceptional Maternal Shift Work on Postpartum Weight Retention.

Objectives: This study examined whether gestational weight gain (GWG) mediates the relationship between maternal shift work and postpartum weight retention (PPWR).

Methods: Mothers with singleton births in the Taiwan Birth Cohort Study were assessed for shift work, GWG, and PPWR. Propensity score matching balanced baseline characteristics.

BTEX exposure and metabolite levels in Taiwan schoolchildren near petrochemical areas.

Introduction: Benzene, toluene, ethylbenzene, and xylenes (BTEX) in ambient air pose significant health risks for residents near petrochemical facilities. However, limited research has investigated the correlation between BTEX exposure and urinary metabolites in children. This is the first study to determine this association among primary school children near petrochemical industrial parks (PIPs) in Taiwan.

Skeletal Muscle Mass and Mortality in Heart Failure: Mediation Role of Systemic Immune-Inflammatory Index.

Background: Heart failure (HF)-related skeletal muscle wasting inversely affects the prognosis of HF, in which systemic inflammation may be involved. The relationships among skeletal muscle mass (SMM), systemic inflammation, and cardiovascular outcomes have not been clarified.

Objectives: This study evaluated the associations of SMM with cardiovascular outcomes, systemic immune-inflammatory index (SII) with cardiovascular outcomes, and the mediation role of SII in the relationship between SMM and outcomes.

UniMap: Type-Level Integration Enhances Biological Preservation and Interpretability in Single-Cell Annotation.

Integrating single-cell datasets from multiple studies provides a cost-effective way to build comprehensive cell atlases, granting deeper insights into cellular characteristics across diverse biological systems. However, current data integration methods struggle with interference in partially overlapping datasets and varying annotation granularities. Here, a multiselective adversarial network is introduced for the first time and present UniMap, which functions as a "discerner" to identify and exclude interfering cells from various data sources during dataset integration.

Efficacy and safety of combined Kahook Dual Blade goniotomy with phacoemulsification in Chinese patients with primary open angle glaucoma.

Aim: To report the one-year surgical outcome Kahook Dual Blade goniotomy combined with phacoemulsification (KDB-Phaco) in Chinese patients with primary open angle glaucoma (POAG).

Methods: This is a retrospective study included 43 eyes of 28 Chinese POAG patients with cataract who accepted KDB-Phaco and followed-up for 12mo. Intraocular pressure (IOP), glaucoma medications and surgical complications were recorded.

Short- and long-term outcomes of neoadjuvant chemotherapy compared with neoadjuvant chemoradiotherapy for locally advanced rectal cancer: an updated meta-analysis.

Background And Purpose: Neoadjuvant chemoradiotherapy (NACRT) is the standard treatment regimen for locally advanced rectal cancer (LARC) but has unavoidable radiation toxicity. With the advent of more optimized chemotherapy regimens, neoadjuvant chemotherapy (NAC) is sometimes offered as an alternative to NACRT. The purpose of this meta-analysis was to compare the short- and long-term outcomes of NAC and NACRT for LARC patients.

The UBR5 protein facilitates mesangial cell hypertrophy and glycolysis induced by high glucose by increasing the phosphorylation levels of AKT.

Aims: One of the primary pathological features in the early stages of diabetic nephropathy is mesangial cell (MC) hypertrophy in the glomerulus. Considering the role of E3 ubiquitin ligases in regulating MC hypertrophy, the aim of this study was to identify the functional ubiquitin protein ligase E3 component N-recognin 5 (UBR5) during MC hypertrophy under high glucose conditions.

Methods: Human MCs (HMCs) transduced with UBR5 silencing or overexpression vector were treated with high glucose, AKT inhibitor, or glycolysis inhibitor.

Personalized Jargon Identification for Enhanced Interdisciplinary Communication.

Scientific jargon can confuse researchers when they read materials from other domains. Identifying and translating jargon for individual researchers could speed up research, but current methods of jargon identification mainly use corpus-level familiarity indicators rather than modeling researcher-specific needs, which can vary greatly based on each researcher's background. We collect a dataset of over 10K term familiarity annotations from 11 computer science researchers for terms drawn from 100 paper abstracts.

Chitosan hydrochloride coated and nonionic surfactant modified niosomes: a better way for oral administration of semaglutide.

Diabetes is now a global chronic disease, with the number of people with diabetes expected to reach 643 million by the end of 2030. Semaglutide, a human glucagon-like peptide-1 (GLP-1) analogue with 94% similarity to human GLP-1, can promote insulin secretion and repress glucagon secretion in a glucose concentration-dependent manner, resulting in substantial improvement of blood glucose levels and reducing the risk of hypoglycemia in patients with type 2 diabetes. To improve the absorption efficiency of semaglutide in oral delivery, we developed chitosan hydrochloride-coated and nonionic surfactant-modified niosomes (CS.

Effect of the cervical and thoracic "Daoyin" training on posture and pulmonary function in patients with upper crossed syndrome: a randomized controlled trial.

Objectives: With the growing ubiquity of electronic devices, the incidence of upper crossed syndrome (UCS) is increasing every year and tends to affect younger populations. The study was designed to assess the effect of cervical and thoracic "Daoyin" training on pain, posture, pulmonary function, cervical range of motion, and emotional state in college students with UCS.

Design: We conducted a parallel-group randomized control study.

Equations for Predicting the 10-Year Risk of Atherosclerotic Cardiovascular Disease in Population With Obesity.

Background: Atherosclerotic cardiovascular disease (ASCVD) is a significant public health issue; however, current risk prediction models have limitations in populations with obesity.

Objectives: The aim of this study was to develop risk models for predicting ASCVD risk in patients with obesity.

Methods: Gender-specific equations to predict ASCVD were developed and validated using a cohort of 3,058 participants with obesity (body mass index ≥30 kg/m) in the ARIC (Atherosclerosis Risk In Communities) study and 1,953 participants in MESA (Multi-Ethnic Study of Atherosclerosis).

SlABCG9 Functioning as a Jasmonic Acid Transporter Influences Tomato Resistance to .

Jasmonic acid (JA) is crucial for plant stress responses, which rely on intercellular jasmonate transport. However, JA transporters have not been fully identified, especially in tomato ( L.).

Sex Differences in the Association Between Cardiovascular Autonomic Neuropathy and Mortality in Patients With Type 2 Diabetes: The ACCORD Study.

Background: Cardiovascular autonomic neuropathy (CAN) is a severe complication of type 2 diabetes. Significant sex-related differences have been observed in type 2 diabetes consequences such as mortality. However, the effect of sex on the association between CAN and mortality in patients with type 2 diabetes is currently unknown.

Idebenone Protects Photoreceptors Impaired by Oxidative Phosphorylation Disorder in Retinal Detachment.

Purpose: Oxidative phosphorylation (OXPHOS) is an aerobic metabolic mechanism, and its dysfunction plays an important role in the pathological changes of ischemic diseases. However, systematic studies on the occurrence of retinal detachment (RD) are lacking.

Methods: Single-cell RNA sequencing (scRNA-seq) of the human retina was performed to detect the metabolic changes of various retinal cells after RD.

Proximity to petrochemical industry and risk of childhood asthma occurrence.

Adverse effects on the respiratory system were associated with intensive petroleum-related industrial activities. The study aimed to assess the impact of petrochemical exposure on childhood asthma using various surrogate indices. A singleton birth cohort from 2004 to 2017 was conducted, leveraging two linked nationwide databases in Taiwan.

Long-term exposure to multiple air pollutants and risk of Parkinson's disease: a population-based multipollutant model study.

Background: Recent evidence suggests brain-first Parkinson's disease (PD) may start from the olfactory system, indicating potential inhalational exposure to causal agents. We investigated the impact of long-term exposure to various air pollutants on PD incidence using both single- and multi-pollutant models to account for interactions between pollutants.

Methods: This retrospective population study used data from Taiwan's National Health Insurance Research Database (2006 and 2018) and included individuals aged 40-65 without PD.

Polyethylene terephthalate nanoplastics affect potassium accumulation in foxtail millet (Setaria italica) seedlings.

Background: As modern industrial activities have advanced, the prevalence of microplastics and nanoplastics in the environment has increased, thereby impacting plant growth. Potassium is one of the most crucial nutrient cations for plant biology. Understanding how polyethylene terephthalate (PET) treatment affects potassium uptake will deepen our understanding of plant response mechanisms to plastic pollution.

Nuclear receptor 4A1 facilitates complete Freund's adjuvant-induced inflammatory pain in rats by promoting ferroptosis in spinal glial cells.

Glial cell-induced neuroinflammation in the spinal cord is the critical pathology underlying complete Freund's adjuvant (CFA)-induced inflammatory pain. Previously, we showed that spinal glial cells undergo ferroptosis after CFA injection, which may contribute to the development of neuroinflammation and inflammatory pain. However, the mechanism underlying the occurrence of ferroptosis during inflammatory pain remains unclear.

Design and synthesis of JNK1-targeted PROTACs and research on the activity.

Kinase dysregulation is greatly associated with cell growth, proliferation, differentiation and apoptosis, which indicates their great potential as therapeutic targets for treatment of numerous progressive disorders, including inflammatory, metabolic and autoimmune disorders, organ fibrosis and cancer. The c‑Jun N‑Terminal Kinase (JNK), as a member of MAPK family, is proved to be a potential target for the treatment of pulmonary fibrosis, which is the most common progressive and fatal fibrotic lung disease. As a new strategy, small-molecule-mediated targeted protein degradation pathway has the advantages of catalytic properties, overcoming drug resistance and expanding target space, which can circumvent the limitations associated with kinase inhibitors.

In Operando Optical Analysis of Electrolyte Colour Change and Its Correlation to Capacity Fade in Li-Ion Cells at Elevated Temperatures.

The existing body of research on battery state of health has identified various degradation modes for the electrolyte, yet very few studies have explored the role of electrolyte colour changes as a diagnostic tool for state of health (SOH). This study investigates the impact of elevated temperatures and its correlation with electrolyte colour changes and capacity fade during cycling. Specifically, the research examines whether cycling cells at elevated temperatures induces noticeable changes in electrolyte colour and whether these changes can be linked to the SOH of the cells.

Pt@WS Mott-Schottky Heterojunction Boosts Light-Driven Active Ion Transport for Enhanced Ionic Power Harvesting.

Bioinspired light-driven ion transport in two-dimensional (2D) nanofluidics offers exciting prospects for solar energy harvesting. Current single-component nanofluidic membranes often suffer from low light-induced driving forces due to the easy recombination of photogenerated electron-hole pairs. Herein, we present a Pt@WS Mott-Schottky heterojunction-based 2D nanofluidic membrane for boosting light-driven active ion transport and solar enhanced ionic power harvesting.

Vacancy engineering in tungsten oxide nanofluidic membranes for high-efficiency light-driven ion transport.

Bioinspired light-driven ion transport has shown great potential in solar energy harvesting. To achieve efficiencies comparable to biological counterparts, effective coregulation of permselectivity and photoresponsivity is crucial. Herein, vacancy engineering has been proven to be a powerful strategy for considerably increasing the efficiency of light-driven ion transport in tungsten oxide (WO) nanofluidic membranes by enhancing the negative surface charges and narrowing bandgaps.