Novel Variants in the Gene Causing Multisystem Proteinopathy 1.

Valosin-containing protein () gene mutations have been associated with a rare autosomal dominant, adult-onset progressive disease known as multisystem proteinopathy 1 (MSP1), or inclusion body myopathy (IBM), Paget's disease of bone (PDB), frontotemporal dementia (FTD), (IBMPFD), and amyotrophic lateral sclerosis (ALS). We report the clinical and genetic analysis findings in five patients, three from the same family, with novel gene variants: NM_007126.5 (), (), and (), associated with cardinal MSP1 manifestations including myopathy, PDB, and FTD.

Emerging role of SIRT2 in non-small cell lung cancer.

Non-small cell lung cancer (NSCLC) is one of the most devastating cancer types, accounting for >80% of lung cancer cases. The median relative survival time of patients with NSCLC is <1 year. Lysine acetylation is a major post-translational modification that is required for various biological processes, and abnormal protein acetylation is associated with various diseases, including NSCLC.

A processed metabolite of luteinizing hormone-releasing hormone has proliferative effects in endometrial cells.

Objective: The purpose of this study is to determine the possible role of the processed peptide of LHRH, LHRH-(1-5), in regulating growth of endometrial cancer cells.

Study Design: An endometrial cancer cell line, the Ishikawa cell line, was cultured under standard conditions and treated in a dose-dependent manner with 1 of 2 hormones, LHRH and LHRH-(1-5) to determine the ability of these peptides to regulate cellular growth. A tetrazolium-based assay was used to determine the effect these peptides have on cell proliferation.

Inorganic photoreduction of nicotinamide adenine dinucleotide phosphate. I. Photoreduction by certain oxide semiconductors in the near ultraviolet.

The action of chloroplasts in the light reactions of photosynthesis is the reduction of NADP to NADPH and phosphorylation of ADP to ATP by light energy. According to the electron theory of catalysis of photosynthesis, these functions of chloroplasts can be mimicked by any inorganic semiconductors. This paper reports that with ZnO instead of chloroplasts NADP can be photoreduced to NADPH in the near ultraviolet.