Association of thrombus enhancement with mortality following endovascular therapy in patients with acute anterior circulation stroke.

Background: Thrombus enhancement sign (TES) has emerged as a potential imaging biomarker in patients with acute ischemic stroke (AIS) undergoing endovascular thrombectomy (EVT).

Objective: To evaluate the prognostic value of TES on 90-day mortality and functional outcomes.

Methods: We conducted a prospective, two-center study involving 323 patients with AIS treated with EVT.

Causal effect of C-reaction protein and endometrial cancer: Genetic evidence of the role of inflammation in endometrial cancer.

Consensus remains elusive regarding the relationship between C-reactive protein (CRP) levels and endometrial cancer (EC). Our study sought to elucidate the causal association between CRP and EC, aiming to contribute to the understanding of this complex interplay. We primarily utilized the random-effects inverse variance-weighted method.

Intra-Arterial Urokinase After Endovascular Reperfusion for Acute Ischemic Stroke: The POST-UK Randomized Clinical Trial.

Importance: Persisting or new thrombi in the distal arteries and the microcirculation have been reported to limit the benefits of successful endovascular thrombectomy for patients with acute ischemic stroke. It remains uncertain whether intra-arterial thrombolysis by urokinase following near-complete to complete reperfusion by thrombectomy improves outcomes among patients with ischemic stroke due to large vessel occlusion.

Objective: To assess the efficacy and adverse events of intra-arterial urokinase after near-complete to complete reperfusion by thrombectomy for acute ischemic stroke due to large vessel occlusion.

Carbon sink potential and the cost of afforestation in northwest China when accounting for ecosystem service value.

The cost effectiveness of mitigating climate change through afforestation needs to be evaluated for regions with a fragile environment and vulnerable ecosystems. This study develops an integrated geographic-economic-ecological framework to evaluate the cost-effectiveness of afforestation for carbon sequestration in Northwest China. It employs a spatial model of natural factors and a bioeconomic optimization model to identify marginal lands suitable for afforestation.

Elevated CO Shifts Photosynthetic Constraint from Stomatal to Biochemical Limitations During Induction in and .

The relative impacts of biochemical and stomatal limitations on photosynthesis during photosynthetic induction have been well studied for diverse plants under ambient CO concentration (). However, a knowledge gap remains regarding how the various photosynthetic components limit duction efficiency under elevated CO. In this study, we experimentally investigated the influence of elevated CO (from 400 to 800 μmol mol) on photosynthetic induction dynamics and its associated limitation components in two broadleaved tree species, and .

[The application of full-thickness advancement flap of upper abdominal wall in breast-conserving surgery for lower quadrant breast cancer].

To explore the application of full-thickness advancement flap of upper abdominal wall in breast-conserving surgery for lower quadrant breast cancer. This is a retrospective case series study. The clinic data of 25 lower quadrant breast cancer patients who underwent a breast-conserving surgery with advancement flap of full-thickness of upper abdominal wall at the Breast Center, Beijing Tongren Hospital, Capital Medical University, from June 2022 to September 2023 were analyzed retrospectively.

Emergence of two novel tmexCD-toprJ subtypes mediating tigecycline resistance in the megaplasmids from Pseudomonas putida.

The widespread antimicrobial resistance (AMR) problem poses a serious health threat, leaving few drug choices, including tigecycline, to treat multidrug resistance pathogens. However, a plasmid-borne tigecycline resistance gene cluster, tmexCD1-toprJ1, emerged and conferred tigecycline resistance. In this study, we identified two novel subtypes, tmexCD2.

Self-calibrating temperature sensing strategy based on KBaY(MoO):Pr phosphor luminescence characteristics with excellent relative temperature sensitivity.

Non-contact temperature sensors have gained immense popularity due to their inherent benefits, including the absence of physical interaction with targets and rapid response characteristics. In this work, KBaY(MoO):Pr was successfully synthesized utilizing a high-temperature solid-phase method. Experimental studies have indicated that multi-phonon relaxation (MPR), cross-relaxation (CR), and the unique intervalence charge transfer state (IVCT) exhibited by Pr-Mo contribute to the changes in luminescence properties.

MALAT1 promotes epithelial-mesenchymal transition of pancreatic cancer cells through the miR-141-5p-TGF-ß-TGFBR1/TGFBR2 axis.

Pancreatic cancer (PC) is one of the leading causes of cancer deaths, associated with a high risk of metastasis and mortality. The long non-coding RNA (lncRNA) metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is highly expressed in multiple types of tumour tissues and may be associated with the growth of PC cells. In this study, we aimed to assess the role and possible mechanisms of MALAT1 in PC progression.

Leveraging Multivalent Assembly towards High-Temperature Liquid-Phase Phosphorescence.

High-temperature phosphorescence (HTP) materials have attracted considerable attention owing to their expanded application prospects, whereas they still suffer from severe deactivation in polar media, limiting their reliability and utility. Here, we present an efficient multivalent assembly strategy to achieve high-temperature liquid-phase phosphorescence (HTLP). The supramolecular assembly of multivalent modules leads to extremely robust hydrogen-bonding networks, which firmly immobilize the organic phosphors and protect triplet excitons from annihilation in high-temperature polar media, resulting in excellent HTLP emission.

Genetically Engineered Hypoimmune Human Muscle Progenitor Cells Can Reduce Immune Rejection.

Cells face two challenges after transplantation: recognition and killing by lymphocytes, and cell apoptosis induced by the transplantation environment. Our hypoimmune cells aim to address these two challenges through editing of immunomodulatory proteins and overexpression of anti-apoptotic proteins.

Efficacy and safety of tirofiban in acute ischemic stroke patients with ideal reperfusion: A cohort study of LAA and CE subgroups.

Background And Objectives: Despite achieving ideal reperfusion (eTICI = 3) through endovascular treatment (EVT), some acute ischemic stroke (AIS) patients still experience poor outcomes. This study aims to evaluate the efficacy and safety of tirofiban in AIS patients with ideal reperfusion, focusing on its effects in large artery atherosclerosis (LAA) and cardioembolic (CE) stroke.

Methods: A total of 474 AIS patients from the RESCUE-BT database were included.

R(3780) Resonance Interpreted as the 1^{3}D_{1}-Wave Dominant State of Charmonium from Precise Measurements of the Cross Section of e^{+}e^{-}→Hadrons.

We report the precise measurements of the cross section of e^{+}e^{-}→hadrons at center-of-mass energies from 3.645 to 3.871 GeV.

Unraveling the drivers of optimal stomatal behavior in global C plants: A carbon isotope perspective.

Understanding the drivers of stomatal behavior is critical for modeling terrestrial carbon cycle and water balance. The unified stomatal optimization (USO) model provides a mechanistic linkage between stomatal conductance (g) and photosynthesis (A), with its slope parameter (g) inversely related to intrinsic water use efficiency (iWUE), providing a key proxy to characterize the differences in iWUE and stomatal behavior. While many studies have identified multiple environmental factors influencing g, the potential role of evolutionary history in shaping g remains incompletely understood.

Daphnetin may protect from SARS-CoV-2 infection by reducing ACE2.

To combat the SARS-CoV-2 pandemic, innovative prevention strategies are needed, including reducing ACE2 expression on respiratory cells. This study screened approved drugs in China for their ability to downregulate ACE2. Daphnetin (DAP) was found to significantly reduce ACE2 mRNA and protein levels in PC9 cells.

Weak fault feature extraction method of rolling bearing based on wavelet packet decomposition and optimized MCKD.

The early fault characteristics of rolling bearings are weak, especially in a strong noise environment, which are more difficult to extract; therefore, a method based on wavelet packet decomposition, multi-verse optimizer, and maximum correlated kurtosis deconvolution for weak fault feature extraction of rolling bearings is proposed. First, the original vibration signal is decomposed using wavelet packet decomposition, followed by proposing a signal reconstruction method combining the Pearson correlation coefficient and energy ratio to effectively remove noise from the original signal. Second, the parameters L and M of Maximum Correlated Kurtosis Deconvolution (MCKD) are optimized using the multi-verse optimizer algorithm to obtain optimal filter settings.

ACE Loss Drives Renal Cell Carcinoma Growth and Invasion by Modulating AKT-FOXO1.

Purpose: Emerging literature links the role of the renin-angiotensin-aldosterone system (RAAS) to the progression of cancers. However, the function of RAAS has not been verified in Clear-cell renal cell carcinoma (ccRCC).

Methods: ACE expression in ccRCC tissues was determined using RT-PCR, Western blot, and immunohistochemistry staining.

Efficacy of azithromycin combined with compounded atovaquone in treating babesiosis in giant pandas.

Background: Babesia is a tick-borne protozoan blood parasite that can cause hemolytic anemia, thrombocytopenia, lethargy and splenomegaly in giant pandas.

Methods: We evaluated the efficacy and safety profile of a therapeutic regimen combining atovaquone and zithromycin in the context of babesiosis in giant pandas that have been naturally infected. The examined pandas underwent clinical and laboratory analyses, including hematology, biochemistry and thyroid hormone profiles.

Application of clown care in hospitalized children: A scoping review.

Purpose: This study aims to provide healthcare providers with insights into relevant interventions by examining the timing, format, content, outcome measures, and effects of clown care interventions on hospitalized children.

Methods: This study utilized a scoping review methodology based on the framework by Arksey and O'Malley. The search for Chinese and English literature on the utilization of clown care for hospitalized children was conducted in databases including CNKI, VIP, Wanfang, China Biology Medicine Database, PubMed, Embase, Web of Science, CINAHL, and Cochrane Library.

Explainable Machine Learning Predictions for the Benefit From Chemotherapy in Advanced Non-Small Cell Lung Cancer Without Available Targeted Mutations.

Background: Non-small cell lung cancer (NSCLC) is a global health challenge. Chemotherapy remains the standard therapy for advanced NSCLC without mutations, but drug resistance often reduces effectiveness. Developing more effective methods to predict and monitor chemotherapy benefits early is crucial.

Windfarm construction alters soil multinutrient cycling by destabilizing microfauna community in a mountain ecosystem.

In recent decades, investors attracted to wind power's promise of zero-emission electricity have fueled the proliferation of large windfarms across the world. However, the effects of windfarm construction with different land use subtypes (i.e.

Geographical Distribution Dynamics of in China Under Climate Change.

, a perennial emergent herb, is highly valued for its ornamental appeal, water purification ability, and medicinal properties. However, there is a significant contradiction between the rapidly increasing demand for and the diminishing wild resources. Understanding its geographical distribution and the influence of global climate change on its geographical distribution is imperative for establishing a theoretical framework for the conservation of natural resources and the expansion of its cultivation.

Analysis of Taste Quality Differences Between High and Low Grades of Ninghong Tea: From the Perspective of Sensory, Metabolite, and Taste Activity Values.

In this study, the taste quality difference between high (Ninghong-Jinhao tea, JH, unfolded fresh leaves) and low (Ninghong-Congou tea, CG, unfurled fresh leaves) grades of Ninghong tea (unique black tea) was analyzed from the perspective of sensory omics, non-targeted metabolomics, and chemical dose. JH was characterized by sweetness and mellowness with umami, while CG was characterized by sweetness and thickness. A total of 94 differential metabolites contribute to the quality difference between two grades.

Promotion of angiogenesis and suppression of inflammatory response in skin wound healing using exosome-loaded collagen sponge.

Effectively promoting skin wound healing remains a significant challenge in the medical field. Although stem cell-derived exosomes show potential in tissue regeneration, their local delivery and sustained release face challenges. To address these issues, we developed a collagen sponge based on type I and recombinant humanized type III collagen.

Superhydrophilic membrane coupled with hydroxide ion-assisted bubbles for efficient separation of surfactant-stabilized oil/water emulsions.

Developing a feasible and efficient membrane for the purification of surfactant-stabilized emulsions is urgently needed but impeded by the issues of membrane fouling and the inherent trade-off between separation efficiency and permeation flux. A superhydrophilic conductive membrane was developed by coating MXene/carbon nanotubes layer and polydopamine-hydrogel molecular layer, which as cathode integrates feasible hydroxide ion-assisted bubbles on its surface by electrolysis of water. These bubbles are more effective than conventional ones in removing surfactant-stabilized oil droplets because the hydroxide ions significantly promote the aggregation of oil droplets and bubbles by reducing their Debye length.