Publications by authors named "Yudong Ma"

Background: Diarrhea is usually observed in newborn Hu lambs, while severe diarrhea may lead to the stunted growth and even death in lambs, necessitating the common practice of antibiotic administration to newborns. In order to explore the application of the effective probiotics and/or prebiotic treatment in animal feed to lessen the recline on antibiotics, 27 newborn of Hu lambs were equally allocated into three groups: control group (Con), probiotics group (Pro) receiving Lactiplantibacillus plantarum N-1 (LPN-1), and synbiotics group (Syn) receiving LPN-1 combined with isomaltose-oligosaccharide (IMO), and raised till 60 days of age.

Results: Compared with the Con, the incidence of severe diarrhea was lower in both two treatment groups, accompanied by a significant reduction in terramycin administration frequency (P < 0.

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Cardiac or myocardial dysfunction induced by sepsis, known as sepsis-induced cardiomyopathy or sepsis-induced myocardial injury (SIMI), is a common complication of sepsis and is associated with poor outcomes. However, the pathogenesis and molecular mechanisms underlying SIMI remain poorly understood, requiring further investigations. Emerging evidence has shown that NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) inflammasomes contribute to SIMI.

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Background: Rheum palmatum, R. tanguticum, and R. officinale, integral species of the genus Rheum, are widely used across global temperate and subtropical regions.

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Article Synopsis
  • Rhubarb leaf blades (LRO) are rich in protein, fiber, and minerals, but their nutrient levels fluctuate based on the harvest season.
  • As harvest time progresses from March to July, protein and amino acid levels decrease, while other nutrients peak around May or June.
  • The study highlights LRO's potential for functional food production, emphasizing that antioxidant-related nutrients also vary with the season.
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Osteosarcoma predominantly affects adolescents and young adults and is characterized as a malignant bone tumor. In recent decades, substantial advancements have been achieved in both diagnosing and treating osteosarcoma. Resulting in enhanced survival rates.

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This study was conducted to increase the enzymatic activity of XS-4, which was isolated from the traditional fermented mash of Xianshi soy sauce. The mutation was induced by atmospheric and room-temperature plasma (ARTP), and a mutant strain, mut80, was obtained. mut80 exhibited significant increases in protease and amylase activity by 90.

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complex (MTBC), the main cause of TB in humans and animals, is an extreme example of genetic homogeneity, whereas it is still nevertheless separated into various lineages by numerous typing methods, which differ in phenotype, virulence, geographic distribution, and host preference. The large sequence polymorphism (LSP), incorporating region of difference (RD) and H37Rv-related deletion (RvD), is considered to be a powerful means of constructing phylogenetic relationships within MTBC. Although there have been many studies on LSP already, focusing on the distribution of RDs in MTBC and their impact on MTB phenotypes, a crumb of new lineages or sub-lineages have been excluded and RvDs have received less attention.

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Background: The para-Bombay phenotype is a rare red blood cell phenotype characterised by the lack of ABH antigens on red blood cells, but ABH substances can be found in saliva. The aim of this research was to study the mechanism of mutation of FUT1 and FUT2 genes and the pedigree of a family with the para-Bombay phenotype.

Material And Methods: The blood group was detected by a conventional serological method, H antigen adsorption-elution test, and testing saliva for A, B, and H antigens.

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Background: There is little consensus on endovascular treatment for symptomatic intracranial posterior circulation stenosis via the transradial approach (TRA). We report our multicenter experience and technical procedures that directly used a distal access catheter (DAC) via TRA for the treatment of symptomatic intracranial vertebral (VA) and basilar (BA) artery stenosis.

Methods: From January 2019 to December 2020, 92 consecutive patients with severe symptomatic intracranial VA or BA stenosis were retrospectively collected and divided into two groups (TRA group and transfemoral approach (TFA) group) for neurointerventional treatment.

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Self-assembled charge-transfer complexes based on supramolecular interactions have attracted immense research interest due to their unique packing and (opto)electronic applications. Herein, two new binary cocrystals with a similar 1:1 mixed-stack arrangement are synthesized by solvent evaporation or grinding method using N,N'-dimethyl-1,4,5,8-naphthalene tetracarboxylic diimide (Me-NDI) as the receptor. Single-crystal X-ray diffraction analysis confirms the successful molecular-level recognition and various weak interaction networks.

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Background: Osteosarcoma is the most frequent primary malignant tumor of bone. SLC19A1 has been explored as a novel biomarker in some cancers. In this research, the diagnostic and prognostic value of SLC19A1 expression in osteosarcoma was evaluated by bioinformatics analysis.

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Rapid detection of Acinetobacter baumannii (AB) is critical for limiting healthcare-associated infections and providing the best treatment for infected individuals. Herein an integrated microfluidic device for AB diagnosis utilizing a new dual aptamer assay was developed for point-of-care (POC) applications; magnetic beads coated with AB-specific aptamers were used to capture bacteria, and quantum dots (QD) bound to a second aptamer were utilized to quantify the amount of bacteria with a light-emitting diode (LED)-induced fluorescence module integrated into the device. Within a rapid detection of 30 min, a limit of detection of only 100 colony-forming units (CFU)/reaction was obtained, and all necessary microfluidic devices were actuated by a combination of permanent magnets and electromagnets.

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Binary charge-transfer complex polymorphs composed of perylene and 4,8-bis(dicyanomethylene)-4,8-dihydrobenzo-[1,2-:4,5-']-dithiophene (DTTCNQ) were synthesized separately via a simple artificial nucleation-tailoring method, in both macroscopic and microscopic cocrystal engineering manners. The two polymorphs were testified to be independently thermosalient in the solid state, and the specific self-assembly derived from homogeneous or heterogeneous nucleation by assistance of governable thermodynamic/kinetic drive, leading to a change in the ordered p-n stacking structure. The as-prepared polymorphic microcrystals afforded a significantly varied (opto)electronic property: high n-type transporting and good photoresponsivity for β-complex, and ambipolar transporting with ignorable photoresponsivity for α-complex, attributing to the different charge-transfer and supramolecular alignment.

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Organic cocrystals are formed the self-assembly of donor and acceptor constituents, which are mixed together through weak noncovalent interactions. Although they reveal unique physical features, their synthesis still faces major drawbacks for the introduction of more potential semiconductors. Herein, we first report soluble pentacene derivative (TMTES-P) based complexes, with suitable alkyl terminal groups, enabling the location of 4,8-bis(dicyanomethylene)-4,8-dihydrobenzo[1,2-:4,5-']-dithiophene (DTTCNQ) in the crystal lattice, thereby allowing the cocrystallization of a binary system on demand.

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H1N1, a subtype of influenza A virus, has emerged as a global threat in the past decades. Due to its highly infectious nature, an accurate and rapid detection assay is urgently required. Therefore, this study presents a new type of digital microfluidic platform for H1N1 virus detection by utilizing a one-aptamer/two-antibodies assay on magnetic beads.

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Delayed cerebral vasospasms (DCVS) may affect the prognosis of patients after subarachnoid hemorrhage (SAH), but available preventive approaches are inefficient. The objective of this study was to explore the effects of cardamonin treatment on factors associated with the occurrence of DCVS after SAH. Rat models of SAH were created using the internal carotid artery puncture method.

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Emerging and re-emerging infectious diseases pose global threats to human health. Although several conventional diagnostic methods have been widely adopted in the clinic, the long turn-around times of "gold standard" culture-based techniques, as well as the limited sensitivity of lateral-flow strip assays, thwart medical progress. In this study, a smartphone-controlled, automated, and portable system was developed for rapid molecular diagnosis of pathogens (including viruses and bacteria) via the use of a colorimetric loop-mediated isothermal amplification (LAMP) approach on a passive, self-driven microfluidic device.

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Circulating extracellular vesicles (EVs), which can contain a wide variety of molecules such as proteins, messenger ribonucleic acids (mRNAs), micro ribonucleic acids (miRNAs) and deoxyribonucleic acids (DNAs) from cells or tissues of origin, have attracted great interest given their potential to serve as biomarkers that can be harvested in body fluids (i.e., relatively non-invasive).

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Although the general balloon occlusion test (BOT) is commonly used, there is limited information on the evaluation standards and methodological protocols for the superselective BOT, which may be required in some special aneurysm cases. We performed the superselective BOT in 12 patients with specific complex aneurysms and report our experiences herein. We retrospectively analyzed the angiographic results and test outcomes of 12 patients (8 men and 4 women) who underwent the superselective BOT to evaluate their collateral flow before treatment.

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Article Synopsis
  • Proximal anterior cerebral artery (A1) aneurysms pose surgical challenges due to their proximity to important blood vessels and surrounding tissue, making clipping difficult.
  • A study analyzed 31 patients (19 males, 12 females) with A1 aneurysms, most presenting with subarachnoid hemorrhage, and found a good overall outcome with an average Glasgow Outcome Scale score of 4.8 after surgery.
  • Effective treatment requires careful imaging analysis, surgical techniques focusing on preserving key blood vessels, and intraoperative monitoring to minimize complications during the procedure.
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Circulating tumor cells (CTCs) are one of the promising cancer biomarkers whose concentrations are measured not only in the initial diagnostic stages, but also as treatment progresses. However, the existing methods for CTC detection are relatively time-consuming and labor-intensive. In this study, a new microfluidic platform integrated with field-effect transistors (FETs) and chambers for the trapping of CTCs was developed.

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Background: Delayed cerebral vasospasm is an important cause of morbidity and mortality in patients with subarachnoid hemorrhage (SAH). This study aimed to assess the effects of Astragaloside IV (AS-IV) on delayed cerebral vasospasm after SAH.

Methods: A rat model of SAH was established by puncturing one side of the internal carotid artery.

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Bacteria such as Acinetobacter baumannii (AB) can cause serious infections, resulting in high mortality if not diagnosed early and treated properly; there is consequently a need for rapid and accurate detection of this bacterial species. Therefore, we developed a new, nitrocellulose-based microfluidic system featuring AB-specific aptamers capable of automating the bacterial detection process via the activity of microfluidic devices composed of magnetic-composite membranes. Electromagnets were used to actuate these microfluidic devices such that the entire diagnostic process could be conducted in the integrated microfluidic system within 40 minutes with a limit of detection as low as 450 CFU per reaction for AB.

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Loop-mediated isothermal amplification (LAMP) is a nucleic acid amplification technique that rapidly amplifies specific DNA molecules at high yield. In this study, a microfluidic droplet array chip was designed to execute the digital LAMP process. The novel device was capable of 1) creating emulsion droplets, 2) sorting them into a 30 × 8 droplet array, and 3) executing LAMP across the 240 trapped and separated droplets (with a volume of 0.

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This study aimed to explore the clinical applications of multimodal navigation combined with indocyanine green (ICG) fluorescein angiography in microsurgical treatment of cerebral arteriovenous malformations (AVMs). We retrospectively collected 52 patients with AVMs. Assisted by anatomic image, we reestablished three-dimensional structure using preoperative functional magnetic resonance imaging (fMRI) and Diffusion tensor imaging (DTI).

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