NAC guides a ribosomal multienzyme complex for nascent protein processing.

Approximately 40% of the mammalian proteome undergoes N-terminal methionine excision and acetylation, mediated sequentially by methionine aminopeptidase (MetAP) and N-acetyltransferase A (NatA), respectively. Both modifications are strictly cotranslational and essential in higher eukaryotic organisms. The interaction, activity and regulation of these enzymes on translating ribosomes are poorly understood.

Fundamental solution of the time-space bi-fractional diffusion equation with a kinetic source term for anomalous transport.

The purpose of this paper is to study the fundamental solution of the time-space bi-fractional diffusion equation incorporating an additional kinetic source term in semi-infinite space. The equation is a generalization of the integer-order model (also known as the Debye-Falkenhagen equation) by replacing the first-order time derivative with the Caputo fractional derivative of order , and the second-order space derivative with the Riesz-Feller fractional derivative of order . Using the Laplace-Fourier transforms method, it is shown that the parametric solutions are expressed in terms of the Fox's H-function that we evaluate for different values of and .

Fractional Marcus-Hush-Chidsey-Yakopcic current-voltage model for redox-based resistive memory devices.

We propose a circuit-level model combining the Marcus-Hush-Chidsey electron current equation and the Yakopcic equation for the state variable for describing resistive switching memory devices of the structure metal-ionic conductor-metal. We extend the dynamics of the state variable originally described by a first-order time derivative by introducing a fractional derivative with an arbitrary order between zero and one. We show that the extended model fits with great fidelity the current-voltage characteristic data obtained on a Si electrochemical metallization memory device with Ag-Cu alloy.

A DNA-encoded chemical library based on chiral 4-amino-proline enables stereospecific isozyme-selective protein recognition.

DNA-encoded chemical libraries (DELs) consist of large chemical compound collections individually linked to DNA barcodes, facilitating pooled construction and screening. However, screening campaigns often fail if the molecular arrangement of the building blocks is not conducive to an efficient interaction with a protein target. Here we postulated that the use of rigid, compact and stereo-defined central scaffolds for DEL synthesis may facilitate the discovery of very specific ligands capable of discriminating between closely related protein targets.

Bacterial Argonaute Proteins Aid Cell Division in the Presence of Topoisomerase Inhibitors in Escherichia coli.

Prokaryotic Argonaute (pAgo) proteins are guide-dependent nucleases that function in host defense against invaders. Recently, it was shown that TtAgo from Thermus thermophilus also participates in the completion of DNA replication by decatenating chromosomal DNA. Here, we show that two pAgos from cyanobacteria Synechococcus elongatus (SeAgo) and Limnothrix rosea (LrAgo) are active in heterologous Escherichia coli and aid cell division in the presence of the gyrase inhibitor ciprofloxacin, depending on the host double-strand break repair machinery.

Bacterial Argonaute nucleases reveal different modes of DNA targeting in vitro and in vivo.

Prokaryotic Argonaute proteins (pAgos) are homologs of eukaryotic Argonautes (eAgos) and are also thought to play a role in cell defense against invaders. However, pAgos are much more diverse than eAgos and little is known about their functional activities and target specificities in vivo. Here, we describe five pAgos from mesophilic bacteria that act as programmable DNA endonucleases and analyze their ability to target chromosomal and invader DNA.

An approach to anisotropic alloying into the Si(001) surface.

By employing density functional theory calculations, we explore the initial stage of competitive alloying of co-deposited silver and indium atoms into a silicon surface. In particular, we identify respective adsorption positions and activation barriers governing their diffusion on a dimer-reconstructed silicon surface. Furthermore, we develop a growth model that appropriately describes diffusion mechanisms and silicon morphology with the account of silicon dimerization and the presence of C-type defects.

Spin-hedgehog-derived electromagnetic effects in itinerant magnets.

In itinerant magnets, the indirect exchange coupling of Ruderman-Kittel-Kasuya-Yosida type is known to stabilize incommensurate spin spirals, whereas an account of higher order spin interactions favors the formation of a noncoplanar magnetic texture. This is manifested by the finite Berry phase the conduction electrons accumulate when their spins follow this texture, leading thus to the topological Hall effect. We herein utilize the effective spin model with bilinear-biquadratic exchange interactions for studying the formation of the magnetic hedgehog lattice, that represents a periodic array of magnetic anti- and monopoles and has been recently observed in the B20-type compounds, in a three-dimensional itinerant magnet.

XMCD and study of interface-engineered ultrathin Ru/Co/W/Ru films with perpendicular magnetic anisotropy and strong Dzyaloshinskii-Moriya interaction.

Understanding the nature of recently discovered spin-orbital induced phenomena and a definition of a general approach for "ferromagnet/heavy-metal" layered systems to enhance and manipulate spin-orbit coupling, spin-orbit torque, and the Dzyaloshinskii-Moriya interaction (DMI) assisted by atomic-scale interface engineering are essential for developing spintronics and spin-orbitronics. Here, we exploit X-ray magnetic circular dichroism (XMCD) spectroscopy at the -edges of 5d and 4d non-magnetic heavy metals (W and Ru, respectively) in ultrathin Ru/Co/W/Ru films to determine their induced magnetic moments due to the proximity to the ferromagnetic layer of Co. The deduced orbital and spin magnetic moments agree well with the theoretically predicted values, highlighting the drastic effect of constituting layers on the system's magnetic properties and the strong interfacial DMI in Ru/Co/W/Ru films.

[A medicinal liver injury with an immunomodulatory drug of natural origin. Case report].

As practice shows, there are many alternative drugs that cause drug damage to the liver. A case of medicinal damage to the liver with an immunomodulatory herbal preparation Immunostimulating collection, which included St. John's wort, Elecampane, Kopeichnik, Echinacea, Licorice, Rosehip, is presented.

Comparison of the Effects of Septoplasty and Sinus Lifting Simulation in Rats on Changes in Heart Rate Variability.

The effects of septoplasty and sinus lifting simulation in rats on changes in the frequency domain of heart rate variability were compared. In the early postoperative period, the low-frequency component increases, and the high-frequency component decreases. The VLF range also increased.

On the origin of the electron accumulation layer at clean InAs(111) surfaces.

In this paper, we provide a comprehensive theoretical analysis of the electronic structure of InAs(111) surfaces with special attention paid to the energy region close to the fundamental bandgap. Starting from the bulk electronic structure of InAs calculated using the PBE functional with the inclusion of Hubbard correction and spin-orbit coupling, we derive proper values for the bandgap, split-off energy, as well as effective electron, light-hole and heavy-hole masses in full consistent with the available experimental results. Besides that we address the projected density of states associated with p orbitals of bulk indium and arsenic atoms.

Localized surface electromagnetic waves in CrI-based magnetophotonic structures.

Resulting from strong magnetic anisotropy two-dimensional ferromagnetism was recently shown to be stabilized in chromium triiodide, CrI, in the monolayer limit. While its properties remain largely unexplored, it provides a unique material-specific platform to unveil its electromagnetic properties associated with coupling of modes. Indeed, trigonal symmetry in the presence of out-of-plane magnetization results in a non-trivial structure of the conductivity tensor, including the off-diagonal terms.

DNA targeting and interference by a bacterial Argonaute nuclease.

Members of the conserved Argonaute protein family use small RNA guides to locate their mRNA targets and regulate gene expression and suppress mobile genetic elements in eukaryotes. Argonautes are also present in many bacterial and archaeal species. Unlike eukaryotic proteins, several prokaryotic Argonaute proteins use small DNA guides to cleave DNA, a process known as DNA interference.

Oxygen vacancy in ZnO-phase: pseudohybrid Hubbard density functional study.

The study of zinc oxide, within the homogeneous electron gas approximation, results in overhybridization of zinc 3d shell with oxygen 2p shell, a problem shown for most transition metal chalcogenides. This problem can be partially overcome by using LDA +(or, GGA +) methodology. However, in contrast to the zinc 3d orbital, Hubbard type correction is typically excluded for the oxygen 2p orbital.

Programmable DNA cleavage by Ago nucleases from mesophilic bacteria Clostridium butyricum and Limnothrix rosea.

Argonaute (Ago) proteins are key players in RNA interference in eukaryotes, where they function as RNA-guided RNA endonucleases. Prokaryotic Argonautes (pAgos) are much more diverse than their eukaryotic counterparts but their cellular functions and mechanisms of action remain largely unknown. Some pAgos were shown to use small DNA guides for endonucleolytic cleavage of complementary DNA in vitro.

[Comparative characteristics of uropathogenic scherichia coli strains, allocated in polyclinic and stationary conditions].

Unlabelled: The etiological structure of urinary tract infections (UTI) is determined by the leading role of uropathogenic Escherichia coli (UPEC). The aim of the work is to study the biological properties and phylogenetic diversity of E. coli strains isolated from UTI in outpatient and inpatient patients.

Resonant spin wave excitation in magnetoplasmonic bilayers using short laser pulses.

In magnetically ordered solids a static magnetic field can be generated by virtue of the transverse magneto-optical Kerr effect (TMOKE). Moreover, the latter was shown to be dramatically enhanced due to the optical excitation of surface plasmons in nanostructures with relatively small optical losses. In this paper we suggest a new method for resonant optical excitation in a prototypical bilayer composed of a noble metal (Au) with grating and a ferromagnetic thin film of yttrium iron garnet (YIG) via a frequency comb.

Another view on Gilbert damping in two-dimensional ferromagnets.

A keen interest towards technological implications of spin-orbit driven magnetization dynamics requests a proper theoretical description, especially in the context of a microscopic framework, to be developed. Indeed, magnetization dynamics is so far approached within Landau-Lifshitz-Gilbert equation which characterizes torques on magnetization on purely phenomenological grounds. Particularly, spin-orbit coupling does not respect spin conservation, leading thus to angular momentum transfer to lattice and damping as a result.

A majority gate with chiral magnetic solitons.

In magnetic materials, nontrivial spin textures may emerge due to the competition among different types of magnetic interactions. Among such spin textures, chiral magnetic solitons represent topologically protected spin configurations with particle-like properties. Based on atomistic spin dynamics simulations, we demonstrate that these chiral magnetic solitons are ideal to use for logical operations, and we demonstrate the functionality of a three-input majority gate, in which the input states can be controlled by applying an external electromagnetic field or spin-polarized currents.

Light-Induced Anisotropic Skyrmion and Stripe Phases in a Rashba Ferromagnet.

An external off-resonant pumping is proposed as a tool to control the Dzyaloshinskii-Moriya interaction (DMI) in ferromagnetic layers with strong spin-orbit coupling. Combining theoretical analysis with numerical simulations for an s-d-like model, we demonstrate that linearly polarized off-resonant light may help stabilize novel noncollinear magnetic phases by inducing a strong anisotropy of the DMI. We also investigate how with the application of electromagnetic pumping one can control the stability, shape, and size of individual Skyrmions to make them suitable for potential applications.

Exploring nonlinear topological states of matter with exciton-polaritons: Edge solitons in kagome lattice.

Matter in nontrivial topological phase possesses unique properties, such as support of unidirectional edge modes on its interface. It is the existence of such modes which is responsible for the wonderful properties of a topological insulator - material which is insulating in the bulk but conducting on its surface, along with many of its recently proposed photonic and polaritonic analogues. We show that exciton-polariton fluid in a nontrivial topological phase in kagome lattice, supports nonlinear excitations in the form of solitons built up from wavepackets of topological edge modes - topological edge solitons.

Nucleolin-Mediated RNA Localization Regulates Neuron Growth and Cycling Cell Size.

How can cells sense their own size to coordinate biosynthesis and metabolism with their growth needs? We recently proposed a motor-dependent bidirectional transport mechanism for axon length and cell size sensing, but the nature of the motor-transported size signals remained elusive. Here, we show that motor-dependent mRNA localization regulates neuronal growth and cycling cell size. We found that the RNA-binding protein nucleolin is associated with importin β1 mRNA in axons.

A spin dynamics approach to solitonics.

In magnetic materials a variety of non-collinear ground state configurations may emerge as a result of competition among exchange, anisotropy, and dipole-dipole interaction, yielding magnetic states far more complex than those of homogenous ferromagnets. Of particular interest in this study are particle-like configurations. These particle-like states, e.