Publications by authors named "Yudi Niu"
Stem cells are widely used in scientific research because of their ability to self-renew and differentiate into a variety of specialized cell types needed for body functions. However, the self-renewal and differentiation of stem cells are regulated by various stimuli, with mechanical stimulation being particularly notable due to its ability to mimic the physical environment in the body. This study systematically collected 2638 research papers published between 1994 and 2024, employing tools such as VOSviewer, CiteSpace, and GraphPad Prism to uncover research hotspots, publication trends, and collaboration networks.
View Article and Find Full Text PDFVisualizing Trends and Bibliometric Study in Tissue Engineering for Rotator Cuff Injuries.
Tissue Eng Part B Rev
August 2024
This research is dedicated to uncovering the evolving trends, progressive developments, and principal research themes in tissue engineering and regenerative medicine for rotator cuff injuries, which spans the past two decades. This article leverages visualization methodology to provide a clear and comprehensive portrayal of the dynamic landscape within the field. We compiled 758 research entries centered on the application of tissue engineering and regenerative medicine in treating rotator cuff injuries, drawing from the Web of Science Core Collection database and covering the period from 2003 to 2023.
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- Cell encapsulation technology faces challenges with existing methods; microfluidics can harm cells, while conventional electrospray suffers from instability and breakage at high throughput.
- A new superimposed electric field (SEF)-enhanced electrospray method improves stability and biocompatibility, allowing for fast production of around 300 core-shell capsules per second.
- This method leads to significant advancements, such as increasing iPSC growth by 92 times compared to traditional cultures and creating liver capsules for modeling liver diseases, showing promise for clinical applications like transplantation and drug screening.*
Article Synopsis
- The regeneration of hierarchical osteochondral units is complicated due to challenges in directing mesenchymal stem cells (MSCs) to differentiate into cartilage and bone.
- The study introduced gelatin-based microcryogels made with hyaluronic acid (HA) and hydroxyapatite (HYP) to promote cartilage (CH-Microcryogels) and bone (OS-Microcryogels) regeneration through self-assembly into osteochondral organoids.
- Results showed that these microcryogels were effective in promoting chondrogenic and osteogenic differentiation, reduced inflammation, and successfully regenerated osteochondral units in canine models, highlighting a promising new strategy for tissue engineering.
Article Synopsis
- The study reveals that advanced glycation end-products (AGEs) contribute to the crosslinking of the extracellular matrix in cirrhotic liver tissue, indicating high levels of crosslinking as a key feature of cirrhosis.
- Using advanced mass spectrometry, researchers measured crosslinking in liver samples, demonstrating that AGE-induced structural changes can be mimicked in lab-grown collagen matrices.
- The study identifies rosmarinic acid as a potential treatment that can inhibit AGE-mediated crosslinking and slow down liver fibrosis progression, suggesting new therapeutic strategies for addressing liver scarring.
Scar-Degrading Endothelial Cells as a Treatment for Advanced Liver Fibrosis.
Adv Sci (Weinh)
February 2023
Article Synopsis
- The study explores how the extracellular matrix (ECM) contributes to liver cirrhosis and the challenges in recovery due to its resistant scar tissue.
- A new screening system was developed (CEDSS) to identify liver sinusoidal endothelial cells (dLSECs) with a significantly higher ability (17 times greater) to degrade collagen compared to other cells, largely due to the upregulation of the enzyme MMP9.
- The research indicates that injecting dLSECs into mice helps reduce advanced liver fibrosis, suggesting these cells could be a promising therapeutic avenue for treating liver diseases.
Mechanical hallmarks of fibrotic microenvironments are both outcomes and causes of fibrosis progression. Understanding how cells sense and transmit mechanical cues in the interplay with extracellular matrix (ECM) and hemodynamic forces is a significant challenge. Recent advances highlight the evolvement of intracellular mechanotransduction pathways responding to ECM remodeling and abnormal hemodynamics (i.
View Article and Find Full Text PDFIt is still a challenge for synthesizing 'cellular niche-mimics' with satisfactory reproducibility and fidelity to recreate the natural niche components (e.g., extracellular matrices and soluble factors) for stem cell cultivation.
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- * The study proposes a new stent design that utilizes 3D modeling and fluid dynamics, achieving an optimized geometry with a 10% enlargement of the surface area to enhance blood flow to side branches.
- * Simulation results indicate that the new stent design significantly increases side branch pressure by 43.6% and improves wall shear stress, thereby optimizing blood supply to downstream organs without increasing areas of low shear stress.
Complex nanostructures with distinct spatial architectures and more active sites hold broad prospects in new energy conversion fields. Herein, a facile strategy was carried out to construct triple-shelled Co-VSe nanocages, starting with an ion-exchange process between Co-based zeolitic imidazolate framework-67 (ZIF-67) nanopolyhedrons and VO followed by the formation of triple-shelled Co-VSe hollow nanocages during the process of increasing the solvothermal temperature under the assistance of SeO. Meanwhile, triple-shelled Co-VS and yolk-double shell Co-VO nanocages were fabricated as references by a similar process.
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