Publications by authors named "Yudai Tsuruno"

We herein report a neonatal case showing specific findings of blood perfusion in the anastomosed esophagus of esophageal atresia (EA) and tracheoesophageal fistula (TEF) using indocyanine green (ICG) fluorescence during thoracoscopic surgery. The patient was a 3054 g, 0-day neonatal boy diagnosed with EA-TEF based on a coil-up sign of the nasogastric tube. Thoracoscopic surgery was performed on Day 4 after birth.

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Article Synopsis
  • * Real-time shear wave elastography (SWE) was used to measure liver stiffness and fibrosis stages in patients, with most showing low fibrosis levels and only one showing F3 fibrosis due to recurrent cholangitis.
  • * The findings suggest that while liver fibrosis is rare in patients without complications post-surgery, those with long-term issues should be regularly checked using SWE to prevent overlooking potential liver cirrhosis.
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Purpose: This study investigated the anti-inflammatory effect of clodronate, a vesicular nucleotide transporter (VNUT) inhibitor, on intestinal-failure-associated liver disease (IFALD) in a rat model of short bowel syndrome (SBS).

Methods: The rats underwent jugular vein catheterization for continuous total parenteral nutrition (TPN) and 90% small bowel resection. The animals were divided into the following groups: TPN/SBS (Control group), TPN/SBS/intravenous administration of low-dose clodronate (20 mg/kg twice per week; Low group), or TPN/SBS/intravenous administration of high-dose clodronate (60 mg/kg twice per week; High group).

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Article Synopsis
  • The study explores how the branching of the portal vein and lymphatic vessels contribute to liver atrophy in biliary atresia (BA).
  • Liver biopsy samples from ten BA patients were analyzed using specific staining techniques to compare the left lateral segment (LLS) and right anterior segment (RAS) of the liver.
  • Findings indicated that the LLS had higher fibrosis scores and showed a significant correlation between lymphatic vessel numbers and both fibrosis and age at surgery, suggesting a link between lymphatic growth and liver damage in BA.
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Article Synopsis
  • * Out of 43 patients analyzed, 69.8% experienced cholangitis, with significant episodes occurring before age 3; however, key inflammatory markers were similar between patients with native liver survival (NLS) and those undergoing liver transplants (LDLT).
  • * Notably, the NLS group showed a lower neutrophil-to-lymphocyte ratio, indicating a lymphocyte-dominant form of cholangitis, suggesting different pathways in its development—highlighting the need for further research to guide better treatment and outcomes for BA patients
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Intussusception is a common cause of intestinal obstruction in infants aged 6-18 months. However, intussusception in preterm neonates (IPN) is an exceedingly rare disorder. The etiology of IPN remains unclear, but common prenatal injuries, such as those causing intestinal hypoxia/hypoperfusion, dysmotility, and strictures, have been proposed as possible contributing factors.

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Purpose: This study assessed the efficacy of a high-impact, short-term workshop in honing the laparoscopic hepaticojejunostomy technical skills and self-confidence of novice pediatric surgeons, focusing on vertical needle driving and knot tying.

Methods: Lectures, hands-on sessions, pre- and post-workshop evaluations, and training using porcine models were conducted to refine basic and advanced skills. The "hepaticojejunostomy simulator" was used for comparative analysis of precision in pre- and post-workshop vertical needle driving and knot tying.

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Purpose: Testicular torsion requires emergency surgery; thus, prompt and correct diagnosis is very important. Ultrasound with color Doppler is usually the first-choice modality for diagnosis; however, skill and experience are required for confident diagnosis. Recently, contrast-enhanced ultrasound for the diagnosis of testicular torsion has been reported, but there have been only a few reports.

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Background: Pleuropulmonary blastoma (PPB) is an extremely rare and malignant pediatric lung tumor. Purely cystic PPB has a more favorable prognosis than solid PPB, but may be difficult to distinguish from a certain type of "benign" congenital pulmonary airway malformation before and during surgery. The influence of tumor rupture on long life prognosis has not been clarified in detail.

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Purpose: Torsion of the appendix testis or epididymis is a cause of acute scrotum in children. Ultrasonography with color Doppler is the first-choice modality for diagnosis. However, this method requires skill and experience to make a diagnosis with confidence.

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Background: Extremely low birth weight (< 1000 g) still influences postsurgical prognosis in the neonatal and infantile periods. Additionally, the life expectancy of neonates with trisomy 18 is extremely poor owing to various comorbidities. Therefore, it takes courage to perform laparotomy for the purpose of treatment of congenital multiple intestinal atresia in a baby with an unpredictable life prognosis.

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Background: Thoracotomy with posterolateral incision (PLI) is commonly used for surgical repair of patent ductus arteriosus (PDA) in extremely low birth weight (ELBW) infants. Some reports have described thoracotomy for PDA using an axillary skin crease incision (ASCI) in consideration of cosmetic problems such as surgical wounds and thoracic deformities, but the details remain unclear.

Methods: In this study, we performed clipping ligation by thoracotomy with ASCI for ELBW infants with PDA from 2011 to 2015 for the purpose of improving cosmetic results, and retrospectively compared the results with those for conventional PLI cases performed from 2016 to 2020.

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Background: Necrotizing fasciitis in neonates is a rare and life-threatening infection involving necrosis of the skin, subcutaneous tissues, deep fascia, and sometimes underlying muscles, with a fulminant course and high mortality rate. Necrotizing fasciitis with gas gangrene related to infection of a peripherally inserted central catheter is very rare.

Case Presentation: The patient was a full-term female neonate born by vaginal delivery.

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Background: Repair of esophageal atresia is usually performed through the right thoracic cavity. However, when the upper pouch of the esophagus and tracheoesophageal fistula (TEF) is located in the thoracic inlet and completely on the left side of trachea, it is difficult to dissect and anastomose the esophagus through the right thoracic cavity. We present a case of esophageal atresia, with the esophageal upper pouch located high and completely on the left side of trachea, successfully repaired via the median sternotomy approach.

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Synopsis of recent research by authors named "Yudai Tsuruno"

  • * Recent studies highlight the significance of inflammation patterns in post-operative cholangitis and their predictive value for long-term outcomes in biliary atresia patients, as well as the benefits of enhanced lymphangiogenesis observed during surgeries.
  • * Tsuruno also explores advanced diagnostic techniques and surgical approaches, emphasizing the challenges and considerations in managing complex cases such as congenital intestinal atresia and esophageal atresia in extremely low birth weight infants.