Development of microparticles coated with poly-γ-glutamic acid to improve oral absorption of a poorly water-soluble drug.

Novel microparticles coated with poly-γ-glutamic acid (PGA) were developed to improve the oral absorption of indomethacin (IM), a poorly water-soluble drug. Microparticles containing γ-IM (IM-PGA) or crystal polymorph α-IM (IM-PGA) were prepared. Additionally, microparticles were prepared containing α-IM without PGA (IM without PGA).