Core-Shell Au@Pd Bimetallic Nanozyme Mediated Mild Photothermal Therapy through Reactive Oxygen Species-Regulating Tumor Thermoresistance.

Mild photothermal therapy (mPTT), which circumvents the limitations of conventional photothermal therapy, is emerging and exhibits remarkable potential in clinical applications. Nevertheless, mPTT is not able to efficiently eradicate tumors because its therapeutic efficacy is dramatically diminished by stress-induced heat shock proteins (HSP). Herein, a core-shell structured Au@Pd (AP) bimetallic nanozyme was fabricated for reactive oxygen species (ROS) augmentation-induced mPTT.

Low-Temperature Photothermal Therapy Platform Based on Pd Nanozyme-Modified Hydrogenated TiO.

In photothermal treatments (PTTs), normal tissues around cancerous tumors get injured by excessive heat, whereas damaged cancer cells are easily restored by stress-induced heat shock proteins (HSPs) at low temperatures. Therefore, to achieve a unique tumor microenvironment (TME), it is imperative to increase PTT efficiency and reduce normal tissue injury by adopting appropriate reactive oxygen species (ROS) and lipid peroxides (LPO) cross-linked with HSPs. In the present research, a potential strategy for mild photothermal treatments (mPTTs) was proposed by initiating localized catalytic chemical reactions in TME based on Pd nanozyme-modified hydrogenated TiO (H-TiO@Pd).

MoC-MoO Heterostructure Quantum Dots for Enhanced Electrocatalytic Nitrogen Reduction to Ammonia.

The electrocatalytic nitrogen reduction reaction (NRR) has been regarded as a promising strategy for producing ammonia (NH) at ambient conditions. However, the development of the NRR is severely hindered by the difficult adsorption and activation of N on the catalyst surface and the competitive hydrogen evolution reaction (HER) due to the lack of efficient NRR electrocatalysts. Herein, MoC-MoO heterostructure quantum dots embedded in reduced graphene oxide (RGO) are proposed as efficient catalysts for the electrocatalytic NRR.