Copper-Catalyzed Regioselective Annulation of β-Keto Esters and Propargyl Acetates: Access to Polysubstituted Furans.

A copper-catalyzed regioselective annulation reaction, conducted without ligands or oxidants, has been developed for the preparation of multisubstituted furans from the readily available starting materials, β-keto esters and propargyl acetates. This process accommodates a wide range of functional groups, resulting in furan skeletons with diverse substitution patterns. The method's potential synthetic utility is highlighted by its applicability in gram-scale preparations and late-stage modifications of natural products.

Maternal aspartame exposure alters lung Th1/Th2 cytokine balance in offspring through nuclear factor-κB activation.

Background: Epidemiological evidence suggests that maternal intake of nonnutritive sweeteners is positively associated with early childhood asthma incidence. We investigated the effects of maternal aspartame exposure during pregnancy and lactation on lung Th1/Th2 cytokine balance and intestinal microbiota in offspring and explored the mechanisms that mediate these effects.

Method: Pregnant BALB/c mice were randomly divided on gestational day 7 into two dietary intervention groups: control (drinking water only) and aspartame (drinking water +0.

Network meta-analysis of integrated traditional Chinese and Western medicine in the treatment of Sjogren's syndrome.

Objective: To evaluate efficacy and safety of traditional Chinese medicine (TCM) combined with Western medicine in treatment of Sjogren's syndrome (SS).

Methods: CNKI, WanFang, VIP, CBM, Sinomed, PubMed, Embase, and Web of Science were searched to collect randomized controlled trials (RCTs) of TCM combined with conventional western medicine (CWM) in treating SS from the time of their estalishment to May 2023. The researchers independently screened the literature and extracted data for quality evaluation.

FOLFOX-HAIC combined with targeted immunotherapy for initially unresectable hepatocellular carcinoma: a real-world study.

Background: Hepatic arterial infusion chemotherapy (HAIC) with the FOLFOX regimen has demonstrated efficacy in patients with unresectable hepatocellular carcinoma (HCC). The combined targeted and immunotherapy has emerged as a first-line treatment for liver cancer. In this study, we investigated the clinical efficacy and safety of FOLFOX-HAIC in combination with targeted immunotherapy in patients with untreated, unresectable HCC.

Assessing the influence of green space morphological spatial pattern on urban waterlogging: A case study of a highly-urbanized city.

The extensive expansion of impervious surfaces encroaches on green spaces and causes frequent urban waterlogging disasters. Previous studies have focused mainly on the influence of green space landscape pattern on waterlogging, with less attention given to green space morphological spatial pattern (MSPA). MSPA can be used to differentiate various types of land use morphologies from a microscopic perspective and reveal visualized spatial characteristics.

Breakthroughs in nanoparticle-based strategies for pancreatic cancer therapy.

Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers worldwide, mainly due to its high heterogeneity, resistance to therapy and late diagnosis, with a 5-year survival rate of less than 10%. This dismal prognosis has promoted strategies to develop more effective treatments. Nanoparticle-based strategies have emerged, in the last decades, as a great opportunity because they can enhance drug delivery and promote controlled release, presenting lower side effects than conventional therapeutic regimens.

Covalent bidentate ligand-enabled regioselective Wacker-type oxidation of olefins.

The utilization of Pd(ii)-catalyzed oxidation for the transformation of terminal olefins into methyl ketones has emerged as a particularly intriguing and versatile strategy in organic synthesis. Herein we report a novel Pd(ii)-catalyzed Wacker-type oxidation with covalent bidentate ligands. The ligand, 1-(pyridin-2-yl)-1,2-dihydro-3-indazol-3-one, exhibits excellent performance in converting olefins to ketones.

Selection and verification of reference genes for real-time quantitative PCR in endangered mangrove species Acanthus ebracteatus under different abiotic stress conditions.

Acanthus ebracteatus is an endangered true mangrove species with great ecological and medicinal values. Real-time quantitative PCR (RT-qPCR) has been widely used to investigate transcriptional responses in A. ebracteatus, which can facilitate its protection and medicinal usage.

Gut microbiome and body composition with sorbitol intake during early lifespan.

Objective: The association of sorbitol intake with maintaining healthy body weight through the gut microbiome during early life was investigated.

Research Methods And Procedures: Sorbitol intake, body mass index (BMI), and fecal samples were collected in the total of 369 pregnant women with their infants (aged 4 months to 5 years) from the Taipei Mother-Infant Nutrition Cohort and 1946 children and adolescents (aged 6-18 years) from the Taiwan Puberty Longitudinal Study. The BMI-z score in sorbitol users was compared to that in sorbitol nonusers using generalized linear mixed model.

Comparative Plastome Analysis Between Endangered Mangrove Species and Relatives Provides Insights into Its Origin and Adaptive Evolution.

is a typical true mangrove species with great ecological and medicinal values. However, it has become endangered in China. Moreover, because of the similar morphology and distribution, it is commonly confused with the congeneric mangrove species, , which poses challenges to the protection and proper medicinal utilization of .

Alternative splicing perspective to prey preference of environmentally friendly biological agent Cryptolaemus montrouzieri.

Background: Cryptolaemus montrouzieri (Coccinellidae) is widely utilized as biological control agents in modern agriculture. A comprehensive understanding of its food preference can help guide mass rearing and safety management during field application of pest control. Although some studies have paid attentions to the impacts of prey shift on C.

Comparison of organelle genomes between endangered mangrove plant to terrestrial relative provides insights into its origin and adaptative evolution.

is a mangrove associate with high medicinal and ecological values. However, due to the dual-pressure of climate change and human activities, has become endangered in China. Moreover, misidentification between and its terrestrial relative poses further challenges to field protection and proper medicinal usage of .

Fluorine-Free Amphiphobic SBS/PAN Micro/Nanofiber Membrane by Integrating Click Reaction with Electrospinning for Efficient and Recyclable Air Filtration.

The membrane fouling derived from the accumulated dust pollutants and highly viscous oily particles causes irreversible damage to the filtration performance of air filters and results in a significant reduction in their service life. However, it is still challenging to construct high-efficiency and antifouling air filtration membranes with recyclable regeneration. Herein, the fluorine-free amphiphobic micro/nanofiber composite membrane was controllably constructed by integrating click chemistry reaction and electrospinning technique.

The complete chloroplast genome of hand.-mazz. 1933 and its implications for phylogenetic relationships in the genus.

Hand.-Mazz. is a rare plant from China in the Elaeagnaceae family.

Circular RNAs in human diseases.

Circular RNAs (circRNAs) are a unique class of RNA molecules formed through back-splicing rather than linear splicing. As an emerging field in molecular biology, circRNAs have garnered significant attention due to their distinct structure and potential functional implications. A comprehensive understanding of circRNAs' functions and potential clinical applications remains elusive despite accumulating evidence of their involvement in disease pathogenesis.

Multi-Channel Multi-Scale Convolution Attention Variational Autoencoder (MCA-VAE): An Interpretable Anomaly Detection Algorithm Based on Variational Autoencoder.

With the rapid development of industry, the risks factories face are increasing. Therefore, the anomaly detection algorithms deployed in factories need to have high accuracy, and they need to be able to promptly discover and locate the specific equipment causing the anomaly to restore the regular operation of the abnormal equipment. However, the neural network models currently deployed in factories cannot effectively capture both temporal features within dimensions and relationship features between dimensions; some algorithms that consider both types of features lack interpretability.

CRISPR-Cas9 knockout screen informs efficient reduction of the Komagataella phaffii secretome.

Background: The yeast Komagataella phaffii is widely used for manufacturing recombinant proteins, but secreted titers of recombinant proteins could be improved by genetic engineering. In this study, we hypothesized that cellular resources could be redirected from production of endogenous proteins to production of recombinant proteins by deleting unneeded endogenous proteins. In non-model microorganisms such as K.