Publications by authors named "Yuchen Liu"

Statement Of Problem: Polyetheretherketone (PEEK) has been used in clinical dentistry because of its excellent physical and biological properties. However, achieving an effective and durable bond with enamel is challenging because of its chemical inertness and low surface energy, and data on the effects of different surface treatments on the durability of PEEK-enamel bonds are scarce.

Purpose: The purpose of this in vitro study was to investigate airborne-particle abrasion, sulfuric acid etching, and the combined use of these treatments on the bonding durability of PEEK-enamel bonds and to gain a deeper understanding of their bonding mechanism.

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Background: Strongyloides nematodes are livestock parasites, and Strongyloides papillosus infecting ruminant livestock can cause disease. Recent genomic analysis of several Strongyloides species is now facilitating population genomic analyses of natural Strongyloides infections, for example finding that Strongyloides ratti in wild UK rats exists as an assemblage of long-lived, asexual lineages.

Methods: Here we have initiated an investigation into the population genomics of S.

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  • * In many cancers, including breast and lung cancer, ANGPTL4 is often found in higher levels, which can lead to increased tumor growth, spread, and resistance to treatment, but it may also have some anti-cancer effects in certain situations.
  • * The regulation of ANGPTL4 involves various factors and pathways, making it a complex player in cancer biology, and it holds promise as a diagnostic tool and target for new cancer therapies.
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The wide dissemination of multidrug-resistant (MDR) Gram-negative bacteria poses a significant global health and security concern. As developing new antibiotics is generally costly, fastidious, and time-consuming, there is an urgent need for alternative therapeutic strategies to address the gap in antibiotic discovery void. This study aimed to investigate the activity of colistin (CS) in combination with a natural product, rutin (RT), to combat against Typhimurium ( Tm) in vitro and in vivo.

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, a plant in the family, is a traditional Chinese medicinal herb known for its unique therapeutic properties, including reported anti-tumor and antioxidant effects. Recent studies suggest that the main constitute of , coumarins, may have potential anti-tumor activity. Recent research suggests that coumarins, the active compounds in , may hold potential anti-tumor activity.

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Background: The geographic distribution of frailty and social deprivation, and their association with mortality in the United States, have not been well studied.

Methods: We estimated claims-based frailty index (CFI) (range: 0-1) and area-level social deprivation index (SDI) (range: 0-100) in a 5% random sample of 1,207,323 Medicare fee-for-service beneficiaries 65 years and older. We examined the prevalence of frailty (defined as CFI ≥ 0.

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The recruitment of T lymphocytes holds great potential for suppressing the most aggressive glioblastoma (GBM) recurrence with immunotherapy. However, the phenomenon of immune privilege and the generally low immunogenicity of vaccines often reduce the presence of lymphocytes within brain tumors, especially in brain tumor recurrence clusters. In this study, an implantable self-cascading catalytic therapy and antigen capture scaffold (CAS) that can boost catalytic therapy efficiency at post-surgery brain tumor and capture the antigens via urethane-polyethylene glycol-polypropylene glycol (PU-EO-PO) segments are developed for postoperative brain immunotherapy.

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  • Two-dimensional layered double hydroxides (LDHs) are being explored for applications in catalysis, water treatment, and energy storage, but existing exfoliation methods face environmental and efficiency challenges.
  • A new solid-phase exfoliation technique has been successfully used to create LDH nanosheets, enhancing their stability and functionality by introducing surface functional groups and defects.
  • The improved LDH nanosheets, particularly NiFe-LDH, show excellent electrocatalytic performance with a low overpotential, showcasing the method's potential as a sustainable way to prepare and functionalize 2D materials.
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Adenosine triphosphate plays a vital role in providing energy and enabling key cellular processes through interactions with binding proteins. The increasing amount of protein sequence data necessitates computational methods for identifying binding sites. However, experimental identification of adenosine triphosphate-binding residues remains challenging.

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  • - The study investigates the role of KLHL23, a member of the Kelch protein superfamily, in cancer by analyzing data from various cancer types in terms of patient survival and immune response.
  • - Multi-omics methods revealed that KLHL23 expression levels are linked to survival rates in specific cancers, like hepatocellular carcinoma and low-grade glioma, as well as the behavior of immune cells and chemotherapy effectiveness.
  • - Reduced levels of KLHL23 are associated with heightened immune activity and a better response to chemotherapy, indicating its potential as a valuable biomarker for cancer prognosis and treatment.
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  • The study emphasizes the importance of early detection and prediction of Alzheimer's disease using neuroimaging techniques like sMRI for brain structure and rsMEG for brain function.
  • A deep learning-based framework, called InterFusion, successfully combined features from both imaging methods, achieving a classification accuracy of 82.7% in distinguishing between Mild Cognitive Impairment and cognitively healthy individuals.
  • The results show that integrating sMRI and rsMEG improves diagnostic accuracy significantly compared to using either method alone, suggesting a promising direction for Alzheimer's research and diagnostics.
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In the realms of bioengineering and biopharmaceuticals, there exists a critical demand for advanced genetic tools that can interact with specific cell signaling pathways to accurately identify and target various cell types. This research introduces the innovative CRISPR-ADAReader system, which enables precise manipulation of cell activity through sensing target RNA. Featuring both positive and negative feedback loops, the system allows for tailored regulation across different cell types in response to various internal signals, showcasing exceptional programmability, specificity, and sensitivity.

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Aim: To compare the accuracy and treatment time of a robotic system (RS) and a dynamic navigation system (DNS) in osteotomy and root-end resection in an in vitro study.

Methodology: In this study, four identical mandibular models were created using three-dimensional (3D) printing, each model including 18 teeth. In the surgical procedures, teeth #35, #33, #32, #42, #43 and #45, along with the mesiobuccal roots of teeth #36 and #46, were specifically selected for operation on each model.

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  • - The connection between MicroRNAs (miRNAs) and diseases is critical, but traditional laboratory methods for predicting these associations are often costly and slow; new Graph Neural Network-based methods (GNN-MDAs) improve this but still have significant limitations.
  • - This study presents DiGAMN, a new model that uses K-means disentangled biological similarity and incorporates memory capabilities to better capture complex relationships in miRNA-disease associations, outperforming existing methods in extensive tests.
  • - Results indicate that DiGAMN achieved impressive performance across multiple datasets with high AUC scores, confirmed its effectiveness through case studies, and highlighted its ability to identify new disease-related miRNAs.
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  • Memory processes, particularly retrieval and reconsolidation, are influenced by dynamic, phase-dependent regulation, with a growing interest in the molecular mechanisms behind this.
  • In a study examining the transcriptome during memory retrieval, researchers found significant gene expression changes at 48 hours post-retrieval, particularly linked to dipeptidyl peptidase 9 (DPP9).
  • The study concluded that DPP9 plays a crucial role in fear memory retrieval, suggesting that specific gene expression patterns are triggered by recent memory retrieval efforts.
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  • Researchers created a new Alzheimer’s disease (AD) model mouse using human tau protein to better understand microglial states related to tau pathology, which hasn't been thoroughly studied yet.
  • The study found that microglia associated with disease increased after tau accumulation, suggesting a shift from age-related microglia to a disease-associated profile in the brains of these model mice.
  • Advanced techniques like single-nucleus RNA sequencing and spatial transcriptomics were employed to highlight how tau propagation affects microglial behavior, paving the way for deeper insights into tau-related changes in the AD brain.
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The presence of large bismuth (Bi) atoms has been shown to increase the spin-orbit splitting energy in bulk GaAsBi, reducing the hole ionization coefficient (β) and thereby reducing the excess noise seen in avalanche photodiodes. In this study, we show that even very thin layers of GaAsBi introduced as quantum wells (QWs) in a GaAs matrix exhibit a significant reduction of β while leaving the electron ionization coefficient, α, largely unchanged. The optical and avalanche multiplication properties of a series of GaAsBi/GaAs multiple quantum well (MQW) p-i-n structures with nominally 5 nm thick, 4.

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Background: All-inside cruciate ligament reconstruction is an emerging technique for treating anterior cruciate ligament and posterior cruciate ligament injuries. The all-inside technique uses a 4-stranded graft made of a single tendon that wraps around itself. Four strands of the graft must be immobilized to form a closed loop, and the free ends of the graft must be attached using a suture technique.

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Exacerbation of scarring can originate from a minority fibroblast population that has undergone inflammatory-mediated genetic changes within the wound microenvironment. The fundamental relationship between molecular and spatial organization of the repair process at the single-cell level remains unclear. We have developed a novel, high-resolution spatial multiomics method that integrates spatial transcriptomics with scRNA-Seq; we identified new characteristic features of cell-cell communication and signaling during the repair process.

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Background: In recent years, Autoimmune diseases (ADs) and hearing loss are both significant public health burdens worldwide. An increasing number of studies are focusing on the potential link between these two diseases and exploring how hearing loss can be prevented and treated in the context of autoimmune diseases. In response to this focus, it is very necessary to conduct bibliometric analysis and molecular mechanism exploration to provide guidance for the exploration of basic mechanisms and clinical management.

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  • - Ovarian cancer (OC) is the most common and lethal cancer in the female reproductive system, particularly when cells spread as single or grouped spheroids in the ascitic fluid.
  • - These spheroids, which include cancer and non-cancer cells, are important for OC progression, but their formation and how they spread are not well understood.
  • - Tumor-associated macrophages (TAMs) play a crucial role in the development and spread of these spheroids and represent a promising target for new therapies against ovarian cancer.
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Nowadays, ticks are considered to be one dangerous blood-sucking ectoparasite for poultries, livestocks and even some wild animals. Therefore, the objectives of this study were to investigate the insecticidal activity of the essential oil extracted from Myristica fragrans Houtt. with the popular name nutmeg (NEO) against the camel ticks, Hyalomma dromedarii.

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Pyroptosis is a form of inflammatory cell death that has been demonstrated to trigger anti-tumor immune responses. Photodynamic therapy (PDT) is an innovative non-invasive treatment for tumors that effectively destroys tumor cells and boosts anti-tumor immune response. The ability of PDT to trigger pyroptosis and its mechanism of action are yet uncertain.

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  • Environmental heat and cold exposure (EHCE) is a major preventable cause of health issues and deaths in children and adolescents worldwide, with a focus on the data from 1990 to 2019.* -
  • The analysis utilized data from the Global Burden of Disease Study, covering 204 countries to track EHCE-related trends, including incidence, prevalence, mortality, and disability-adjusted life-years (DALYs) by various demographics.* -
  • While overall EHCE rates showed a decline from 1990 to 2019, there was a notable increase in incidence and prevalence between 2010 and 2019, especially in regions like Southern sub-Saharan Africa, highlighting significant disparities based on socioeconomic status.*
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